PMID- 34395424
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210817
IS  - 2296-634X (Print)
IS  - 2296-634X (Electronic)
IS  - 2296-634X (Linking)
VI  - 9
DP  - 2021
TI  - P2X7 Receptor Deficiency Ameliorates STZ-induced Cardiac Damage and Remodeling 
      Through PKCbeta and ERK.
PG  - 692028
LID - 10.3389/fcell.2021.692028 [doi]
LID - 692028
AB  - Diabetic cardiomyopathy (DCM) is a complication of diabetes mellitus which result 
      in cardiac remodeling and subsequent heart failure. However, the role of P2X7 
      receptor (P2X7R) in DCM has yet to be elucidated. The principal objective of this 
      study was to investigate whether P2X7R participates in the pathogenesis of DCM. 
      In this study, the C57BL/6 diabetic mouse model was treated with a P2X7R 
      inhibitor (A438079). Cardiac dysfunction and remodeling were attenuated by the 
      intraperitoneal injection of A438079 or P2X7R deficiency. In vitro, A438079 
      reduced high glucose (HG) induced cell damage in H9c2 cells and primary rat 
      cardiomyocytes. Furthermore, HG/streptozotocin (STZ)-induced P2X7R activation 
      mediated downstream protein kinase C-beta (PKCbeta) and extracellular regulated protein 
      kinases (ERK) activation. This study provided evidence that P2X7R plays an 
      important role in the pathogenesis of STZ-induced diabetic cardiac damage and 
      remodeling through the PKCbeta/ERK axis and suggested that P2X7R might be a 
      potential target in the treatment of diabetic cardiomyopathy.
CI  - Copyright (c) 2021 Huang, Wang, Li, Wang, Zhao, Lin, Huang, Wang and Huang.
FAU - Huang, Shanjun
AU  - Huang S
AD  - The Key Laboratory of Cardiovascular Disease of Wenzhou, Department of 
      Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 
      China.
AD  - Department of Cardiology, The Fourth Affiliated Hospital, Zhejiang University 
      School of Medicine, Yiwu, China.
FAU - Wang, Weiqi
AU  - Wang W
AD  - The Key Laboratory of Cardiovascular Disease of Wenzhou, Department of 
      Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 
      China.
FAU - Li, Li
AU  - Li L
AD  - Department of Anesthesiology, The Fourth Affiliated Hospital, Zhejiang University 
      School of Medicine, Yiwu, China.
FAU - Wang, Ting
AU  - Wang T
AD  - The Key Laboratory of Cardiovascular Disease of Wenzhou, Department of 
      Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 
      China.
FAU - Zhao, Yihan
AU  - Zhao Y
AD  - The Key Laboratory of Cardiovascular Disease of Wenzhou, Department of 
      Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 
      China.
FAU - Lin, Ya
AU  - Lin Y
AD  - The Key Laboratory of Cardiovascular Disease of Wenzhou, Department of 
      Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 
      China.
FAU - Huang, Weijian
AU  - Huang W
AD  - The Key Laboratory of Cardiovascular Disease of Wenzhou, Department of 
      Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 
      China.
FAU - Wang, Yonghua
AU  - Wang Y
AD  - Department of Physical Education, Wenzhou Medical University, Wenzhou, China.
FAU - Huang, Zhouqing
AU  - Huang Z
AD  - The Key Laboratory of Cardiovascular Disease of Wenzhou, Department of 
      Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20210729
PL  - Switzerland
TA  - Front Cell Dev Biol
JT  - Frontiers in cell and developmental biology
JID - 101630250
PMC - PMC8358615
OTO - NOTNLM
OT  - ERK
OT  - P2X7 receptor
OT  - PKCbeta
OT  - cardiac remodeling
OT  - diabetic cardiomyopathy
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/08/17 06:00
MHDA- 2021/08/17 06:01
PMCR- 2021/01/01
CRDT- 2021/08/16 06:02
PHST- 2021/04/07 00:00 [received]
PHST- 2021/07/12 00:00 [accepted]
PHST- 2021/08/16 06:02 [entrez]
PHST- 2021/08/17 06:00 [pubmed]
PHST- 2021/08/17 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fcell.2021.692028 [doi]
PST - epublish
SO  - Front Cell Dev Biol. 2021 Jul 29;9:692028. doi: 10.3389/fcell.2021.692028. 
      eCollection 2021.