PMID- 34396557
OWN - NLM
STAT- MEDLINE
DCOM- 20220127
LR  - 20220127
IS  - 1552-4604 (Electronic)
IS  - 0091-2700 (Linking)
VI  - 61 Suppl 2
DP  - 2021 Aug
TI  - Pharmacology of Drugs Used as Stimulants.
PG  - S53-S69
LID - 10.1002/jcph.1918 [doi]
AB  - Psychostimulant, cardiovascular, and temperature actions of stimulants involve 
      adrenergic (norepinephrine), dopaminergic (dopamine), and serotonergic 
      (serotonin) pathways. Stimulants such as amphetamine, 
      3,4-methylenedioxymethamphetamine (MDMA), or mephedrone can act on the neuronal 
      membrane monoamine transporters NET, DAT, and SERT and/or the vesicular monoamine 
      transporter 2 to inhibit reuptake of neurotransmitter or cause release by reverse 
      transport. Stimulants may have additional effects involving pre- and 
      postsynaptic/junctional receptors for norepinephrine, dopamine, and serotonin and 
      other receptors. As a result, stimulants may have a wide range of possible 
      actions. Agents with cocaine or MDMA-like actions can induce serious and 
      potentially fatal adverse events via thermodysregulatory, cardiovascular, or 
      other mechanisms. MDMA-like stimulants may cause hyperthermia that can be life 
      threathening. Recreational users of stimulants should be aware of the dangers of 
      hyperthermia in a rave/club environment.
CI  - (c) 2021 The Authors. The Journal of Clinical Pharmacology published by Wiley 
      Periodicals LLC on behalf of American College of Clinical Pharmacology.
FAU - Docherty, James R
AU  - Docherty JR
AD  - Department of Physiology, RCSI, Dublin, Ireland.
FAU - Alsufyani, Hadeel A
AU  - Alsufyani HA
AD  - Department of Physiology, King Abdulaziz University, Jeddah, Saudi Arabia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - J Clin Pharmacol
JT  - Journal of clinical pharmacology
JID - 0366372
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Neurotransmitter Transport Proteins)
RN  - 333DO1RDJY (Serotonin)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Central Nervous System Stimulants/*pharmacology
MH  - Dopamine/metabolism
MH  - Humans
MH  - Neurotransmitter Transport Proteins/metabolism
MH  - Norepinephrine/metabolism
MH  - Serotonin/metabolism
MH  - Substance-Related Disorders/epidemiology/pathology
EDAT- 2021/08/17 06:00
MHDA- 2022/01/28 06:00
CRDT- 2021/08/16 06:20
PHST- 2021/02/24 00:00 [received]
PHST- 2021/05/22 00:00 [accepted]
PHST- 2021/08/16 06:20 [entrez]
PHST- 2021/08/17 06:00 [pubmed]
PHST- 2022/01/28 06:00 [medline]
AID - 10.1002/jcph.1918 [doi]
PST - ppublish
SO  - J Clin Pharmacol. 2021 Aug;61 Suppl 2:S53-S69. doi: 10.1002/jcph.1918.