PMID- 34396640
OWN - NLM
STAT- MEDLINE
DCOM- 20211103
LR  - 20220531
IS  - 1447-0756 (Electronic)
IS  - 1341-8076 (Linking)
VI  - 47
IP  - 11
DP  - 2021 Nov
TI  - Research progress in teratoma-associated anti-N-methyl-D-aspartate receptor 
      encephalitis: The gynecological perspective.
PG  - 3749-3757
LID - 10.1111/jog.14984 [doi]
AB  - AIM: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is one of the 
      autoimmune encephalitis, which often occurs in children and young adults, 
      especially in young women. In addition to viral infection, teratoma is an 
      important causative factor. Anti-NMDAR encephalitis is well known to neurologist. 
      However, this is less well known to gynecologists, who may have a decisive role 
      in etiological management. Therefore, from the perspective of gynecologists, we 
      provide an overview of the relationship between the encephalitis and ovarian 
      teratoma, the clinical features and treatment of this disease, and prognosis of 
      pregnant women with this encephalitis. METHODS: We searched the PubMed database 
      using the search terms in various combinations "teratoma," "dermoid cyst," 
      "ovary," "ovarian," "anti-NMDAR encephalitis," and "N-methyl-D-aspartate 
      receptor." RESULTS: According to the current literature, the mechanism of 
      anti-NMDAR encephalitis is probably due to the ectopic expression of the NMDAR in 
      the teratomas tissue. The disease has a high mortality rate if not treated 
      promptly and effectively. An important way to improve patients' outcome is to 
      remove the ovarian tumor in time. Pregnant women are also at risk of developing 
      anti-NMDAR encephalitis during pregnancy. The fetal outcome is usually better in 
      patients with mid- to late-pregnancy onset than in early pregnancy, and patients 
      are often able to maintain their pregnancies into late pregnancy. CONCLUSION: 
      Young women with sudden onset of abnormal psychiatric behavior should be actively 
      screened for ovarian tumors and, if confirmed to be teratoma-associated 
      anti-NMDAR encephalitis, should undergo gynecologic surgery as early as possible, 
      which can help improve their prognosis.
CI  - (c) 2021 Japan Society of Obstetrics and Gynecology.
FAU - Gu, Jiaxin
AU  - Gu J
AD  - Department of Obstetrics and Gynecology, West China Second University Hospital, 
      Sichuan University, Chengdu, China.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children 
      (Sichuan University), Ministry of Education, Sichuan, China.
FAU - Chen, Qian
AU  - Chen Q
AD  - Department of Obstetrics and Gynecology, West China Second University Hospital, 
      Sichuan University, Chengdu, China.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children 
      (Sichuan University), Ministry of Education, Sichuan, China.
FAU - Gu, Handong
AU  - Gu H
AD  - Department of Radiology, DaZhou Central Hospital, Dazhou, China.
FAU - Duan, Ruiqi
AU  - Duan R
AD  - Department of Obstetrics and Gynecology, West China Second University Hospital, 
      Sichuan University, Chengdu, China.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children 
      (Sichuan University), Ministry of Education, Sichuan, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210815
PL  - Australia
TA  - J Obstet Gynaecol Res
JT  - The journal of obstetrics and gynaecology research
JID - 9612761
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - *Anti-N-Methyl-D-Aspartate Receptor Encephalitis/diagnosis/therapy
MH  - Child
MH  - Female
MH  - Humans
MH  - *Ovarian Neoplasms
MH  - Pregnancy
MH  - Prognosis
MH  - Receptors, N-Methyl-D-Aspartate
MH  - *Teratoma
MH  - Young Adult
OTO - NOTNLM
OT  - anti-NMDAR encephalitis
OT  - mechanism
OT  - oophorocystectomy
OT  - ovarian teratoma
OT  - pregnancy
EDAT- 2021/08/17 06:00
MHDA- 2021/11/04 06:00
CRDT- 2021/08/16 06:26
PHST- 2021/07/30 00:00 [revised]
PHST- 2021/05/28 00:00 [received]
PHST- 2021/08/02 00:00 [accepted]
PHST- 2021/08/17 06:00 [pubmed]
PHST- 2021/11/04 06:00 [medline]
PHST- 2021/08/16 06:26 [entrez]
AID - 10.1111/jog.14984 [doi]
PST - ppublish
SO  - J Obstet Gynaecol Res. 2021 Nov;47(11):3749-3757. doi: 10.1111/jog.14984. Epub 
      2021 Aug 15.