PMID- 34397025
OWN - NLM
STAT- MEDLINE
DCOM- 20210817
LR  - 20220425
IS  - 1119-3077 (Print)
VI  - 24
IP  - 8
DP  - 2021 Aug
TI  - Trends and Burden of Hepatitis B Viral Infection in Children and Adults in a 
      Tertiary Health Facility in North East Nigeria Over a Fifteen-year Period.
PG  - 1164-1169
LID - 10.4103/njcp.njcp_425_20 [doi]
AB  - BACKGROUND: Hepatitis B infection is endemic in Nigeria where greater than six 
      percent of the general population are chronic carriers. Transmission 
      predominantly occurs in infants and children when compared with adults. Viral 
      hepatitis deaths are mostly due to chronic liver disease. Routine immunization 
      against hepatitis B virus infection in Nigeria is still low. AIMS: We planned to 
      describe the burden and trend of hepatitis B viral infection at Federal Teaching 
      Hospital, Gombe. METHODOLOGY: This study was a retrospective cross-sectional 
      descriptive study. The results of all hepatitis B surface antigen (HBsAg) tests 
      using rapid chromatographic immunoassay performed at the Federal Teaching 
      Hospital, Gombe (FTHG), Nigeria from January 2000 to December 2014 were retrieved 
      and analyzed. RESULTS: Between 2000 and 2014, 23,611 individuals ranging from 2 
      months to 98 years of age were tested for HBsAg. A total of 13,136 (55.6%) were 
      males and 10,475 (44.4%) were females. Among individuals tested for hepatitis B 
      surface antigen, 18.9% (4,456) were positive. A total of 70.6% (3,147) were males 
      and 29.4% (11,239) were females. Male sex was significantly associated with HBsAg 
      positivity (P < 0.001). The mean HBsAg prevalence over the 15-year periods among 
      males and females were 22% and 12%, respectively (P < 0.001). The mean yearly HBV 
      prevalence was 17.5%, 17.2%, 19.6%, 15.5%, and 4.4% among age-groups 0-18 years, 
      19-25 years, 26-45 years, 56-65 years, and >65 years, respectively (P = 0.132). 
      The proportion of HBsAg-positive individuals was highest in the year 2012 (28.7%) 
      and lowest in 2014 (1.8%). CONCLUSION: There was an increasing trend in HBV 
      testing and diagnosis in children and adults in our facility over the last 15 
      years. Health facility capacity for HBV treatment and care requires 
      strengthening.
FAU - Isaac, W E
AU  - Isaac WE
AD  - Department of Paediatrics, College of Medical Sciences, Gombe State University, 
      Gombe, Nigeria.
FAU - Jalo, I
AU  - Jalo I
AD  - Department of Paediatrics, College of Medical Sciences, Gombe State University, 
      Gombe, Nigeria.
FAU - Ajani, A
AU  - Ajani A
AD  - Department of Paediatrics, Federal Teaching Hospital, Gombe, Nigeria.
FAU - Oyeniyi, C O
AU  - Oyeniyi CO
AD  - Infectious Diseases Training and Research group, Gombe, Nigeria.
FAU - Abubakar, J D
AU  - Abubakar JD
AD  - Department of Community Medicine, College of Medical Sciences, Gombe State 
      University, Gombe, Nigeria.
FAU - Aremu, J T
AU  - Aremu JT
AD  - Department of Internal Medicine, Federal Teaching Hospital, Gombe, Nigeria.
FAU - Danlami, M H
AU  - Danlami MH
AD  - Department of Medical Microbiology, Federal Teaching Hospital, Gombe, Nigeria.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Niger J Clin Pract
JT  - Nigerian journal of clinical practice
JID - 101150032
RN  - 0 (Hepatitis B Surface Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Female
MH  - Health Facilities
MH  - *Hepatitis B/epidemiology
MH  - Hepatitis B Surface Antigens
MH  - *Hepatitis B virus
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Nigeria/epidemiology
MH  - Prevalence
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Burden
OT  - Nigeria
OT  - hepatitis B
OT  - trend
COIS- None
EDAT- 2021/08/17 06:00
MHDA- 2021/08/18 06:00
CRDT- 2021/08/16 08:49
PHST- 2021/08/16 08:49 [entrez]
PHST- 2021/08/17 06:00 [pubmed]
PHST- 2021/08/18 06:00 [medline]
AID - NigerJClinPract_2021_24_8_1164_323856 [pii]
AID - 10.4103/njcp.njcp_425_20 [doi]
PST - ppublish
SO  - Niger J Clin Pract. 2021 Aug;24(8):1164-1169. doi: 10.4103/njcp.njcp_425_20.