PMID- 34397175
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20231213
IS  - 1541-4337 (Electronic)
IS  - 1541-4337 (Linking)
VI  - 20
IP  - 5
DP  - 2021 Sep
TI  - Residues of glyphosate in food and dietary exposure.
PG  - 5226-5257
LID - 10.1111/1541-4337.12822 [doi]
AB  - Glyphosate is the active ingredient in Roundup((R)) brand nonselective herbicides, 
      and residue testing for food has been conducted as part of the normal regulatory 
      processes. Additional testing has been conducted by university researchers and 
      nongovernmental agencies. Presence of residues needs to be put into the context 
      of safety standards. Furthermore, to appropriately interpret residue data, 
      analytical assays must be validated for each food sample matrix. Regulatory 
      agency surveys indicate that 99% of glyphosate residues in food are below the 
      European maximum residue limits (MRLs) or U.S. Environmental Protection Agency 
      tolerances. These data support the conclusion that overall residues are not 
      elevated above MRLs/tolerances due to agricultural practices or usage on 
      genetically modified (GM) crops. However, it is important to understand that MRLs 
      and tolerances are limits for legal pesticide usage. MRLs only provide health 
      information when the sum of MRLs of all foods is compared to limits established 
      by toxicology studies, such as the acceptable daily intake (ADI). Conclusions 
      from dietary modeling that use actual food residues, or MRLs themselves, combined 
      with consumption data indicate that dietary exposures to glyphosate are within 
      established safe limits. Measurements of glyphosate in urine can also be used to 
      estimate ingested glyphosate exposure, and studies indicate that exposure is <3% 
      of the current European ADI for glyphosate, which is 0.5 mg glyphosate/kg body 
      weight. Conclusions of risk assessments, based on dietary modeling or urine data, 
      are that exposures to glyphosate from food are well below the amount that can be 
      ingested daily over a lifetime with a reasonable certainty of no harm.
CI  - (c) 2021 The Authors. Comprehensive Reviews in Food Science and Food Safety 
      published by Wiley Periodicals LLC on behalf of Institute of Food Technologists.
FAU - Vicini, John L
AU  - Vicini JL
AUID- ORCID: 0000-0002-5890-7380
AD  - Regulatory Sciences, Bayer Crop Science, Chesterfield, Missouri, USA.
FAU - Jensen, Pamela K
AU  - Jensen PK
AUID- ORCID: 0000-0002-4513-5000
AD  - Regulatory Sciences, Bayer Crop Science, Chesterfield, Missouri, USA.
FAU - Young, Bruce M
AU  - Young BM
AUID- ORCID: 0000-0002-7362-0556
AD  - Regulatory Sciences, Bayer Crop Science, Chesterfield, Missouri, USA.
FAU - Swarthout, John T
AU  - Swarthout JT
AUID- ORCID: 0000-0002-3043-9386
AD  - Regulatory Sciences, Bayer Crop Science, Chesterfield, Missouri, USA.
LA  - eng
PT  - Journal Article
DEP - 20210816
PL  - United States
TA  - Compr Rev Food Sci Food Saf
JT  - Comprehensive reviews in food science and food safety
JID - 101305205
RN  - 0 (Pesticide Residues)
RN  - TE7660XO1C (Glycine)
SB  - IM
MH  - Crops, Agricultural
MH  - *Dietary Exposure
MH  - Glycine/analogs & derivatives/analysis
MH  - Humans
MH  - *Pesticide Residues/toxicity
MH  - Glyphosate
OTO - NOTNLM
OT  - Analytical chemistry
OT  - Glyphosate
OT  - Pesticide exposure
OT  - Risk assessment
OT  - Urinary pesticide
EDAT- 2021/08/17 06:00
MHDA- 2021/10/26 06:00
CRDT- 2021/08/16 08:58
PHST- 2021/06/25 00:00 [revised]
PHST- 2020/08/20 00:00 [received]
PHST- 2021/07/06 00:00 [accepted]
PHST- 2021/08/17 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2021/08/16 08:58 [entrez]
AID - 10.1111/1541-4337.12822 [doi]
PST - ppublish
SO  - Compr Rev Food Sci Food Saf. 2021 Sep;20(5):5226-5257. doi: 
      10.1111/1541-4337.12822. Epub 2021 Aug 16.