PMID- 34397338
OWN - NLM
STAT- MEDLINE
DCOM- 20210818
LR  - 20210818
IS  - 0022-9040 (Print)
IS  - 0022-9040 (Linking)
VI  - 61
IP  - 7
DP  - 2021 Jul 31
TI  - Interim Results of the BYHEART Observational Study: Exogenous Phosphocreatine 
      Effect on the Quality of life of Patients with Chronic Heart Failure.
PG  - 22-27
LID - 10.18087/cardio.2021.7.n1649 [doi]
AB  - Aim      Improvement of quality of life is one of the most important goals for 
      the treatment of patients with chronic heart failure (CHF). This study searched 
      for ways to increase the efficiency of CHF treatment based on parameters of 
      quality of life in CHF patients during and after the treatment with exogenous 
      phosphocreatine (EP).Material and methods  The effect of a single course of EP 
      treatment on quality of life of patients with functional class (FC) II-IV CHF 
      with reduced or mid-range left ventricular ejection fraction was studied as a 
      part of the all-Russia prospective observational study BYHEART. The presence of 
      FC II-IV CHF and a left ventricular ejection fraction <50 % were confirmed by 
      results of 6-min walk test (6MWT) and findings of echocardiography after 
      stabilization of the background therapy.Results An interim data analysis showed 
      that the course of EP treatment was associated with a significant improvement of 
      quality-of-life indexes as determined by the Minnesota Living with Heart Failure 
      Questionnaire (LHFQ) total score. These indexes significantly increased and 
      remained at a satisfactory level for 6 mos. following completion of the treatment 
      course. Also, the treatment significantly beneficially influenced the clinical 
      condition of patients (heart failure severity scale), results of 6MWT, and the 
      increase in left ventricular ejection fraction.Conclusion      The conclusions 
      based on results of the interim analysis should be confirmed by results of the 
      completed study. Complete results are planned to be published in 2022.
FAU - Tereschenko, S N
AU  - Tereschenko SN
AD  - National Medical Research Center of Cardiology of the MoH of Russia, Moscow.
FAU - Perepech, N B
AU  - Perepech NB
AD  - Federal State Budgetary Educational Institution of Higher Education St. 
      Petersburg State University, St.-Petersburg.
FAU - Cheremisina, I A
AU  - Cheremisina IA
AD  - Alfasigma Rus LLC, Moscow.
FAU - Belov, V N
AU  - Belov VN
AD  - Voronezh City Clinical Hospital numero sign3, Voronezh.
FAU - Vollis, Y A
AU  - Vollis YA
AD  - Voronezh City Clinical Hospital numero sign4, Voronezh.
FAU - Ispiriyan, A A
AU  - Ispiriyan AA
AD  - Voronezh City Clinical Hospital numero sign3, Voronezh.
FAU - Gridneva, E A
AU  - Gridneva EA
AD  - Voronezh City Outpatient Hospital numero sign 4, Voronezh.
FAU - Ismailova, A A
AU  - Ismailova AA
AD  - Republic of Dagestan Republican Clinical Hospital of Emergency Medical Care, 
      Makhachkala.
FAU - Maltseva, M N
AU  - Maltseva MN
AD  - Clinical Health Resort named after M. Gorky, Voronezh.
FAU - Melnikova, E H
AU  - Melnikova EH
AD  - Central City Hospital, Azov.
FAU - Moiseeva, Y N
AU  - Moiseeva YN
AD  - City Clinical Hospital named after S.P. Botkin, Moscow.
FAU - Petrenko, M I
AU  - Petrenko MI
AD  - City Hospital of Emergency Medical Care named after V.I Lenin, Rostov region, 
      Shakhty.
FAU - Takhtamysheva, M M
AU  - Takhtamysheva MM
AD  - Medical Center "Family", Rostov-on-Don.
FAU - Titova, T S
AU  - Titova TS
AD  - Belgorod Regional Clinical Hospital of St. Joasaph, Belgorod.
FAU - Khaidarova, F R
AU  - Khaidarova FR
AD  - Clinical Hospital for War Veterans, Grozny.
FAU - Savenkova, A N
AU  - Savenkova AN
AD  - Voronezh City Clinical Hospital numero sign 3, Voronezh.
LA  - rus
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20210731
PL  - Russia (Federation)
TA  - Kardiologiia
JT  - Kardiologiia
JID - 0376351
RN  - 020IUV4N33 (Phosphocreatine)
SB  - IM
MH  - Chronic Disease
MH  - *Heart Failure/drug therapy
MH  - Humans
MH  - Phosphocreatine
MH  - *Quality of Life
MH  - Stroke Volume
MH  - Ventricular Function, Left
EDAT- 2021/08/17 06:00
MHDA- 2021/08/19 06:00
CRDT- 2021/08/16 12:20
PHST- 2021/05/12 00:00 [received]
PHST- 2021/05/19 00:00 [accepted]
PHST- 2021/08/16 12:20 [entrez]
PHST- 2021/08/17 06:00 [pubmed]
PHST- 2021/08/19 06:00 [medline]
AID - 10.18087/cardio.2021.7.n1649 [doi]
PST - epublish
SO  - Kardiologiia. 2021 Jul 31;61(7):22-27. doi: 10.18087/cardio.2021.7.n1649.