PMID- 34398230
OWN - NLM
STAT- MEDLINE
DCOM- 20220422
LR  - 20220815
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Print)
IS  - 1047-3211 (Linking)
VI  - 32
IP  - 6
DP  - 2022 Mar 4
TI  - Overlapping Functional Representations of Self- and Other-Related Thought are 
      Separable Through Multivoxel Pattern Classification.
PG  - 1131-1141
LID - 10.1093/cercor/bhab272 [doi]
AB  - Self-reflection and thinking about the thoughts and behaviors of others are 
      important skills for humans to function in the social world. These two processes 
      overlap in terms of the component processes involved, and share overlapping 
      functional organizations within the human brain, in particular within the medial 
      prefrontal cortex (MPFC). Several functional models have been proposed to explain 
      these two processes, but none has directly explored the extent to which they are 
      distinctly represented within different parts of the brain. This study used 
      multivoxel pattern classification to quantify the separability of self- and 
      other-related thought in the MPFC and expanded this question to the entire brain. 
      Using a large-scale mega-analytic dataset, spanning three separate studies 
      (n = 142), we find that self- and other-related thought can be reliably 
      distinguished above chance within the MPFC, posterior cingulate cortex and 
      temporal lobes. We highlight subcomponents of the ventral MPFC that are 
      particularly important in representing self-related thought, and subcomponents of 
      the orbitofrontal cortex robustly involved in representing other-related thought. 
      Our findings indicate that representations of self- and other-related thought in 
      the human brain are described best by a distributed pattern rather than stark 
      localization or a purely ventral to dorsal linear gradient in the MPFC.
CI  - (c) The Author(s) 2021. Published by Oxford University Press. All rights reserved. 
      For permissions, please e-mail: journals.permissions@oup.com.
FAU - Parelman, Jacob M
AU  - Parelman JM
AUID- ORCID: 0000-0002-2316-3625
AD  - Annenberg School for Communication, University of Pennsylvania, Philadelphia, PA 
      19104, USA.
FAU - Dore, Bruce P
AU  - Dore BP
AD  - Desautels Faculty of Management, McGill University, H3A 1G5, Montreal, Canada.
FAU - Cooper, Nicole
AU  - Cooper N
AD  - Annenberg School for Communication, University of Pennsylvania, Philadelphia, PA 
      19104, USA.
FAU - O'Donnell, Matthew Brook
AU  - O'Donnell MB
AD  - Annenberg School for Communication, University of Pennsylvania, Philadelphia, PA 
      19104, USA.
FAU - Chan, Hang-Yee
AU  - Chan HY
AUID- ORCID: 0000-0001-7179-9436
AD  - Amsterdam School of Communication Research, University of Amsterdam, Nieuwe 
      Achtergracht 166, 1018 WV Amsterdam, The Netherlands.
FAU - Falk, Emily B
AU  - Falk EB
AD  - Annenberg School for Communication, University of Pennsylvania, Philadelphia, PA 
      19104, USA.
LA  - eng
GR  - P50 CA101451/CA/NCI NIH HHS/United States
GR  - R01 CA180015/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
SB  - IM
MH  - *Brain/diagnostic imaging
MH  - Brain Mapping
MH  - Gyrus Cinguli
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - *Prefrontal Cortex/diagnostic imaging
MH  - Self Concept
MH  - Temporal Lobe
PMC - PMC8924429
OTO - NOTNLM
OT  - MPFC
OT  - MVPA
OT  - classification
OT  - self-reference
OT  - social
EDAT- 2021/08/17 06:00
MHDA- 2022/04/23 06:00
PMCR- 2022/08/14
CRDT- 2021/08/16 12:57
PHST- 2021/03/17 00:00 [received]
PHST- 2021/07/14 00:00 [revised]
PHST- 2021/07/15 00:00 [accepted]
PHST- 2021/08/17 06:00 [pubmed]
PHST- 2022/04/23 06:00 [medline]
PHST- 2021/08/16 12:57 [entrez]
PHST- 2022/08/14 00:00 [pmc-release]
AID - 6352380 [pii]
AID - bhab272 [pii]
AID - 10.1093/cercor/bhab272 [doi]
PST - ppublish
SO  - Cereb Cortex. 2022 Mar 4;32(6):1131-1141. doi: 10.1093/cercor/bhab272.