PMID- 34398328
OWN - NLM
STAT- MEDLINE
DCOM- 20220208
LR  - 20220208
IS  - 1436-3771 (Electronic)
IS  - 1432-6981 (Linking)
VI  - 26
IP  - 2
DP  - 2022 Feb
TI  - Comparison of calcium and hydroxyl ion release ability and in vivo 
      apatite-forming ability of three bioceramic-containing root canal sealers.
PG  - 1443-1451
LID - 10.1007/s00784-021-04118-w [doi]
AB  - OBJECTIVE: Bioceramic-containing root canal sealers promote periapical healing 
      via Ca(2+) and OH(-) release and apatite formation on the surface. This study 
      aimed to compare Ca(2+) and OH(-) release and in vivo apatite formation of three 
      bioceramic-containing root canal sealers: EndoSequence BC sealer (Endo-BC), MTA 
      Fillapex (MTA-F), and Nishika Canal Sealer BG (N-BG). MATERIALS AND METHODS: 
      Polytetrafluoroethylene tubes filled with sealers were immersed in distilled 
      water for 6 and 12 h and for 1, 7, 14, and 28 days to measure Ca(2+) and OH(-) 
      release. Additionally, tubes filled with sealers were implanted in the backs of 
      rats for 28 days, and in vivo apatite formation was analyzed using an electron 
      probe microanalyzer. RESULTS: Endo-BC released significantly more Ca(2+) than the 
      other sealers at 6 and 12 h and 1 day. Ca(2+) release was significantly lower 
      from N-BG than from Endo-BC and MTA-F at 14 and 28 days. OH(-) release was 
      significantly higher from Endo-BC than from the other sealers throughout the 
      experiment, except at 1 day. OH(-) release was lower from N-BG than from MTA-F at 
      6 h and 7 days. Only Endo-BC implants exhibited apatite-like calcium-, 
      phosphorus-, oxygen-, and carbon-rich spherulites and apatite layer-like calcium- 
      and phosphorus-rich, but radiopaque element-free, surface regions. CONCLUSIONS: 
      Ca(2+) and OH(-) release is ranked as follows: Endo-BC > MTA-F > N-BG. Only 
      Endo-BC demonstrated in vivo apatite formation. CLINICAL RELEVANCE: Endo-BC could 
      promote faster periapical healing than MTA-F and N-BG.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Belal, Razi Saifullah Ibn
AU  - Belal RS
AD  - Division of Cariology, Operative Dentistry and Endodontics, Department of Oral 
      Health Science, Niigata University Graduate School of Medical and Dental 
      Sciences, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan.
FAU - Edanami, Naoki
AU  - Edanami N
AUID- ORCID: 0000-0001-7644-8360
AD  - Division of Cariology, Operative Dentistry and Endodontics, Department of Oral 
      Health Science, Niigata University Graduate School of Medical and Dental 
      Sciences, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan. 
      edanami@dent.niigata-u.ac.jp.
FAU - Yoshiba, Kunihiko
AU  - Yoshiba K
AD  - Division of Oral Science for Health Promotion, Department of Oral Health and 
      Welfare, Niigata University Graduate School of Medical and Dental Sciences, 
      Niigata, Japan.
FAU - Yoshiba, Nagako
AU  - Yoshiba N
AD  - Division of Cariology, Operative Dentistry and Endodontics, Department of Oral 
      Health Science, Niigata University Graduate School of Medical and Dental 
      Sciences, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan.
FAU - Ohkura, Naoto
AU  - Ohkura N
AD  - Division of Cariology, Operative Dentistry and Endodontics, Department of Oral 
      Health Science, Niigata University Graduate School of Medical and Dental 
      Sciences, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan.
FAU - Takenaka, Shoji
AU  - Takenaka S
AD  - Division of Cariology, Operative Dentistry and Endodontics, Department of Oral 
      Health Science, Niigata University Graduate School of Medical and Dental 
      Sciences, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan.
FAU - Noiri, Yuichiro
AU  - Noiri Y
AD  - Division of Cariology, Operative Dentistry and Endodontics, Department of Oral 
      Health Science, Niigata University Graduate School of Medical and Dental 
      Sciences, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, 951-8514, Japan.
LA  - eng
GR  - 19k19020/Grants-in-Aid for Scientific Research from the Japan Society for the 
      Promotion of Science/
PT  - Journal Article
DEP - 20210816
PL  - Germany
TA  - Clin Oral Investig
JT  - Clinical oral investigations
JID - 9707115
RN  - 0 (Apatites)
RN  - 0 (Calcium Compounds)
RN  - 0 (Drug Combinations)
RN  - 0 (Epoxy Resins)
RN  - 0 (Hydroxides)
RN  - 0 (Root Canal Filling Materials)
RN  - 0 (Silicates)
RN  - 9159UV381P (hydroxide ion)
RN  - SY7Q814VUP (Calcium)
MH  - Animals
MH  - Apatites
MH  - Calcium
MH  - Calcium Compounds
MH  - Dental Pulp Cavity
MH  - Drug Combinations
MH  - Epoxy Resins
MH  - Hydroxides
MH  - Materials Testing
MH  - Rats
MH  - *Root Canal Filling Materials
MH  - Silicates
OTO - NOTNLM
OT  - Apatite-forming ability
OT  - Bioceramic-containing root canal sealer
OT  - Calcium ion release
OT  - Electron probe microanalyzer
OT  - Hydroxyl ion release
OT  - Subcutaneous implantation
EDAT- 2021/08/17 06:00
MHDA- 2022/02/09 06:00
CRDT- 2021/08/16 13:01
PHST- 2021/04/30 00:00 [received]
PHST- 2021/07/30 00:00 [accepted]
PHST- 2021/08/17 06:00 [pubmed]
PHST- 2022/02/09 06:00 [medline]
PHST- 2021/08/16 13:01 [entrez]
AID - 10.1007/s00784-021-04118-w [pii]
AID - 10.1007/s00784-021-04118-w [doi]
PST - ppublish
SO  - Clin Oral Investig. 2022 Feb;26(2):1443-1451. doi: 10.1007/s00784-021-04118-w. 
      Epub 2021 Aug 16.