PMID- 34399558
OWN - NLM
STAT- MEDLINE
DCOM- 20210818
LR  - 20210818
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 101
IP  - 31
DP  - 2021 Aug 17
TI  - [Diagnostic value of combined detection of different indicators for type 2 
      diabetes mellitus combined with atherosclerotic disease].
PG  - 2448-2453
LID - 10.3760/cma.j.cn112137-20210207-00380 [doi]
AB  - Objective: To investigate the diagnostic value of serum lipoprotein associated 
      phospholipase A2 (Lp-PLA2), amyloid A (SAA) and immunoglobulin E (IgE) in 
      patients with type 2 diabetes (T2DM) mellitus complicated with atherosclerotic 
      disease. Methods: From June to December 2019, 224 patients with T2DM in the 
      Second Hospital of Lanzhou University were selected, including 144 males and 80 
      females, aged (61+/-11) years. According to the results of imaging examination, the 
      patients were divided into T2DM with AS group (T2DM-AS group, n=160) and T2DM 
      group (n=64); Healthy subjects in the same period were selected as healthy 
      control group (n=160). Lp-PLA2, IgE, SAA, hs-CRP, TC, TG, HDL-C, LDL-C and Hcy 
      were detected in all patients and healthy controls. The correlation between the 
      above indexes, gender, age and T2DM with AS was analyzed; Multivariate logistic 
      regression was used to analyze the risk factors of T2DM with AS. Results: 
      Compared with the healthy control group, the levels of IgE and Lp-PLA2 in T2DM-AS 
      group and T2DM group were increased, and the levels of SAA in T2DM-AS group were 
      increased (all P<0.05); Compared with T2DM group, the levels of Lp-PLA2, IgE and 
      SAA were increased in T2DM-AS group (all P<0.05). T2DM with AS was positively 
      correlated with age, IgE, Lp-PLA2 and SAA (r=0.468, 0.269, 0.486, 0.418, all 
      P<0.05), and negatively correlated with HDL-C (r=-0.338, P<0.05). Multivariate 
      logistic regression analysis showed that age (OR=0.865, 95%CI: 0.763-0.982, 
      P<0.05), IgE (OR=0.910, 95%CI: 0.840-0.987, P<0.05) and Lp-PLA2 (OR=0.942, 95%CI: 
      0.910-0.986, P<0.05) were risk factors of T2DM with AS. ROC curve showed that the 
      combined detection of Lp-PLA2, SAA and IgE could improve the diagnostic 
      efficiency of T2DM with AS (AUC=0.895, P<0.05), the sensitivity was 80.0%, and 
      the specificity was 93.7%. Conclusion: The levels of Lp-PLA2, IgE and SAA 
      increase in T2DM patients with AS. The combined detection of Lp-PLA2, SAA and IgE 
      can improve the diagnostic efficiency of T2DM patients with AS.
FAU - Jiang, W W
AU  - Jiang WW
AD  - Clinical Medical Center,Lanzhou University Second Hospital,Lanzhou 730030,China.
FAU - Niu, J D
AU  - Niu JD
AD  - Clinical Laboratory, Gansu Maternal and Child Health Hospital,Lanzhou 
      730050,China.
FAU - Qi, M J
AU  - Qi MJ
AD  - Clinical Medical Center,Lanzhou University Second Hospital,Lanzhou 730030,China.
FAU - Song, Y W
AU  - Song YW
AD  - Clinical Laboratory, the Second People's Hospital of Lanzhou, Lanzhou 
      730030,China.
FAU - Dang, Y Q
AU  - Dang YQ
AD  - Clinical Medical Center,Lanzhou University Second Hospital,Lanzhou 730030,China.
FAU - Yang, P Q
AU  - Yang PQ
AD  - Clinical Medical Center,Lanzhou University Second Hospital,Lanzhou 730030,China.
FAU - Yang, J
AU  - Yang J
AD  - Clinical Medical Center,Lanzhou University Second Hospital,Lanzhou 730030,China.
FAU - Liu, Y M
AU  - Liu YM
AD  - Clinical Medical Center,Lanzhou University Second Hospital,Lanzhou 730030,China.
LA  - chi
GR  - CY2019‑BJ14/Lanzhou University Second Hospital "Cuiying Science and Technology 
      Innovation" Program/
GR  - 2020B‑045/Project of Educational Commission of Gansu Province/
GR  - 18JR3RA328/Natural Science Foundation of Gansu Province/
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Biomarkers)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.1.1.47 (1-Alkyl-2-acetylglycerophosphocholine Esterase)
SB  - IM
MH  - 1-Alkyl-2-acetylglycerophosphocholine Esterase
MH  - *Atherosclerosis/diagnosis
MH  - Biomarkers
MH  - C-Reactive Protein
MH  - Child, Preschool
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Risk Factors
EDAT- 2021/08/18 06:00
MHDA- 2021/08/19 06:00
CRDT- 2021/08/17 01:51
PHST- 2021/08/17 01:51 [entrez]
PHST- 2021/08/18 06:00 [pubmed]
PHST- 2021/08/19 06:00 [medline]
AID - 10.3760/cma.j.cn112137-20210207-00380 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2021 Aug 17;101(31):2448-2453. doi: 
      10.3760/cma.j.cn112137-20210207-00380.