PMID- 34400921
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240403
IS  - 1734-9338 (Print)
IS  - 1897-4295 (Electronic)
IS  - 1734-9338 (Linking)
VI  - 17
IP  - 2
DP  - 2021 Jun
TI  - FOXO1 and ANGPT2 relative gene expression in non-ST-segment elevation myocardial 
      infarction among patients with or without type 2 diabetes.
PG  - 187-192
LID - 10.5114/aic.2021.107498 [doi]
AB  - INTRODUCTION: It is well known that chronic hyperglycemia or chronic inflammation 
      leads to both FOXO1 and Ang-2 gene (ANGPT2) expression induction in endothelial 
      cells. ANGPT2 and FOXO1 relative gene expression in peripheral blood cells in 
      diabetes and myocardial ischemia were not researched extensively. AIM: Our 
      objective was to evaluate ANGPT2 and FOXO1 gene expression in peripheral blood 
      cells in patients with non-ST elevation myocardial infarction (NSTEMI), both with 
      and without type 2 diabetes mellitus (T2DM), and compare them to the results 
      obtained from T2DM and control subjects. MATERIAL AND METHODS: This was a 
      multi-center, prospective study of 138 NSTEMI patients with/without T2DM, T2DM 
      and a control group. FOXO1, ANGPT2, TBP (TATA box binding protein - as a 
      reference gene) gene expression levels in peripheral blood cells were measured in 
      each patient. Electrocardiography and echocardiography with assessment of 
      ejection fraction (EF) were performed. Patients with NSTEMI underwent urgent (< 
      24 h) coronarography and the SYNTAX score and GRACE 2.0 score were calculated. 
      RESULTS: The ANGPT2 gene relative expression in buffy coat in the analyzed 
      samples was very low and detectable only in 11 patients from all groups (8.66% of 
      all patients). The level of FOXO1 gene relative expression was significantly 
      higher in patients with NSTEMI (median relative expression = 1.39) than in 
      non-NSTEMI patients (median = 1.09) (W = 1578, p < 0.05) regardless of the 
      presence of T2DM. The FOXO1 gene relative expression was not correlated with 
      GRACE 2.0 score or SYNTAX score of NSTEMI patients. We did not observe any 
      significant change in FOXO1 gene expression after successful angioplasty. 
      CONCLUSIONS: On the basis of our results we can conclude that analyzing the 
      ANGPT2 gene relative expression in peripheral blood cells has no role in 
      assessment of CAD complexity among patients with and without T2DM. FOXO1 gene 
      relative expression in blood peripheral cells is elevated in patients with NSTEMI 
      regardless of the presence of T2DM. FOXO1 expression does not decrease after 
      successful percutaneous coronary intervention and is not correlated with the 
      severity of CAD in patients with NSTEMI.
CI  - Copyright: (c) 2021 Termedia Sp. z o. o.
FAU - Skowerski, Tomasz
AU  - Skowerski T
AD  - Department of Cardiology, School of Health Sciences, Medical University of 
      Silesia, Katowice, Poland.
AD  - Department of Internal Medicine, Diabetology and Nephrology, Faculty of Medical 
      Sciences in Zabrze, Medical University of Silesia in Katowice, Poland.
FAU - Nabrdalik, Katarzyna
AU  - Nabrdalik K
AD  - Department of Internal Medicine, Diabetology and Nephrology, Faculty of Medical 
      Sciences in Zabrze, Medical University of Silesia in Katowice, Poland.
FAU - Kwiendacz, Hanna
AU  - Kwiendacz H
AD  - Department of Internal Medicine, Diabetology and Nephrology, Faculty of Medical 
      Sciences in Zabrze, Medical University of Silesia in Katowice, Poland.
FAU - Pajak, Maciej
AU  - Pajak M
AD  - Roslin Institute, Midlothian, Edinburgh, United Kingdom of Great Britain and 
      Northern Ireland.
FAU - Ochala, Andrzej
AU  - Ochala A
AD  - Division of Cardiology and Structural Heart Diseases Medical University of 
      Silesia, Katowice, Poland.
FAU - Mizia-Stec, Katarzyna
AU  - Mizia-Stec K
AD  - First Department of Cardiology, Faculty of Medical Sciences, Medical University 
      of Silesia, Katowice, Poland.
FAU - Gasior, Zbigniew
AU  - Gasior Z
AD  - Department of Cardiology, School of Health Sciences, Medical University of 
      Silesia, Katowice, Poland.
FAU - Gumprecht, Janusz
AU  - Gumprecht J
AD  - Department of Internal Medicine, Diabetology and Nephrology, Faculty of Medical 
      Sciences in Zabrze, Medical University of Silesia in Katowice, Poland.
LA  - eng
PT  - Journal Article
DEP - 20210709
PL  - Poland
TA  - Postepy Kardiol Interwencyjnej
JT  - Postepy w kardiologii interwencyjnej = Advances in interventional cardiology
JID - 101272671
PMC - PMC8356828
OTO - NOTNLM
OT  - angiopoietin-2
OT  - diabetes
OT  - foxo-1
OT  - non-ST elevation myocardial infarction
COIS- The authors declare no conflict of interest.
EDAT- 2021/08/18 06:00
MHDA- 2021/08/18 06:01
PMCR- 2021/06/01
CRDT- 2021/08/17 07:28
PHST- 2021/02/12 00:00 [received]
PHST- 2021/05/24 00:00 [accepted]
PHST- 2021/08/17 07:28 [entrez]
PHST- 2021/08/18 06:00 [pubmed]
PHST- 2021/08/18 06:01 [medline]
PHST- 2021/06/01 00:00 [pmc-release]
AID - 44592 [pii]
AID - 10.5114/aic.2021.107498 [doi]
PST - ppublish
SO  - Postepy Kardiol Interwencyjnej. 2021 Jun;17(2):187-192. doi: 
      10.5114/aic.2021.107498. Epub 2021 Jul 9.