PMID- 34401295
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210818
IS  - 2213-0071 (Print)
IS  - 2213-0071 (Electronic)
IS  - 2213-0071 (Linking)
VI  - 33
DP  - 2021
TI  - Isolated pulmonary cryptococcosis in a patient with Crohn's disease treated with 
      infliximab: A case report and literature review.
PG  - 101459
LID - 10.1016/j.rmcr.2021.101459 [doi]
LID - 101459
AB  - Tumor necrosis factor-alpha (TNF-alpha) inhibitors are widely used to treat various 
      inflammatory conditions, where they have demonstrated excellent efficacy and 
      tolerability. However, increased risk of infections is one of the most important 
      concerns associated with these agents. Reactivation of tuberculosis and fungal 
      infections have emerged as significant infective complications of anti-TNF-alpha 
      therapy. Cryptococcus infection is an opportunistic fungal infection that can 
      occur in patients receiving anti-TNF-alpha treatment. We report a rare case of 
      isolated pulmonary cryptococcosis in a patient undergoing anti-TNF-alpha therapy for 
      Crohn's disease. Our case should alert clinicians to the increased incidence and 
      atypical presentation of pulmonary cryptococcosis in patients receiving 
      anti-TNF-alpha treatment.
CI  - (c) 2021 The Authors.
FAU - Hussein, Mousa
AU  - Hussein M
AD  - Hamad Medical Corporation, Pulmonology Department, Qatar.
FAU - Haq, Irfan Ul
AU  - Haq IU
AD  - Hamad Medical Corporation, Pulmonology Department, Qatar.
FAU - Hameed, Mansoor
AU  - Hameed M
AD  - Hamad Medical Corporation, Pulmonology Department, Qatar.
FAU - Alabbas, Abbas
AU  - Alabbas A
AD  - Hamad Medical Corporation, Pulmonology Department, Qatar.
FAU - Hadi, Hamad Abdel
AU  - Hadi HA
AD  - Hamad Medical Corporation, Infectious Diseases Department, Qatar.
FAU - Elarabi, Anam
AU  - Elarabi A
AD  - Hamad Medical Corporation, Pulmonology Department, Qatar.
FAU - Al-Bozom, Issam
AU  - Al-Bozom I
AD  - Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, 
      Qatar.
LA  - eng
PT  - Case Reports
DEP - 20210624
PL  - England
TA  - Respir Med Case Rep
JT  - Respiratory medicine case reports
JID - 101604463
PMC - PMC8349031
OTO - NOTNLM
OT  - Crohn's disease
OT  - Cryptococcosis
OT  - Fungal infections
OT  - Infliximab
OT  - Tumor necrosis factor-alpha (TNF-alpha) inhibitors
COIS- There is no conflict of interest for this publication by all authors.
EDAT- 2021/08/18 06:00
MHDA- 2021/08/18 06:01
PMCR- 2021/06/24
CRDT- 2021/08/17 07:31
PHST- 2021/04/13 00:00 [received]
PHST- 2021/06/07 00:00 [revised]
PHST- 2021/06/16 00:00 [accepted]
PHST- 2021/08/17 07:31 [entrez]
PHST- 2021/08/18 06:00 [pubmed]
PHST- 2021/08/18 06:01 [medline]
PHST- 2021/06/24 00:00 [pmc-release]
AID - S2213-0071(21)00121-0 [pii]
AID - 101459 [pii]
AID - 10.1016/j.rmcr.2021.101459 [doi]
PST - epublish
SO  - Respir Med Case Rep. 2021 Jun 24;33:101459. doi: 10.1016/j.rmcr.2021.101459. 
      eCollection 2021.