PMID- 34402090
OWN - NLM
STAT- MEDLINE
DCOM- 20210927
LR  - 20240403
IS  - 1098-240X (Electronic)
IS  - 0160-6891 (Print)
IS  - 0160-6891 (Linking)
VI  - 44
IP  - 5
DP  - 2021 Oct
TI  - FEASibility testing a randomized controlled trial of an exercise program to 
      improve cognition for T2DM patients (the FEAST trial): A study protocol.
PG  - 746-757
LID - 10.1002/nur.22174 [doi]
AB  - While cognitive dysfunction is an important concern in persons with type 2 
      diabetes mellitus (T2DM), it has received little attention in the T2DM 
      literature. Although it often remains unrecognized, cognitive dysfunction 
      associated with T2DM can lead to severe consequences. Prior research studies have 
      consistently shown that aerobic exercise enhances cognitive function among 
      healthy subjects. However, very few studies have examined the effects of aerobic 
      exercise on cognitive function in persons with T2DM. In addition, one important 
      single-nucleotide polymorphism that influences cognition in humans is the 
      brain-derived neurotrophic factor (BDNF) Val66Met variant. Despite strong 
      evidence suggesting aerobic exercise has a beneficial effect on cognitive 
      function, there is significant variability in individual response to exercise 
      programs on cognitive outcomes among Val/Val versus Met carriers. However, the 
      evidence on how the BDNF Val66Met variant influences cognitive outcomes following 
      an aerobic exercise intervention among individuals with T2DM is currently 
      lacking. Therefore, the purpose of this randomized controlled trial is to 
      pilot-test a 3-month supervised exercise program to improve plasma BDNF levels 
      and cognition, overall and according to genotypes of the BDNF Val66Met variant. A 
      total of 81 patients with T2DM will be randomly assigned to either aerobic 
      exercise group (n = 54) or attention control group (n = 27) for 3 months. 
      Outcomes of interest include postintervention changes in plasma BDNF levels, 
      fasting blood glucose, hemoglobin A1c, body mass index, executive function, 
      memory, and processing speed. This study will provide further evidence on use of 
      exercise as a non-pharmaceutical, low-cost intervention to improve cognition in 
      this population.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Liu, Tingting
AU  - Liu T
AUID- ORCID: 0000-0002-7348-809X
AD  - Eleanor Mann School of Nursing, University of Arkansas, College of Education and 
      Health Professions, Fayetteville, Arkansas, USA.
FAU - Hettish, Lindsey
AU  - Hettish L
AD  - Eleanor Mann School of Nursing, University of Arkansas, College of Education and 
      Health Professions, Fayetteville, Arkansas, USA.
FAU - Lo, Wen-Juo
AU  - Lo WJ
AD  - Department of Rehabilitation, Human Resources, and Communication Disorders, 
      University of Arkansas College of Education and Health Professions, Fayetteville, 
      Arkansas, USA.
FAU - Gray, Michelle
AU  - Gray M
AD  - Department of Health, Human Performance and Recreation, Exercise Science Research 
      Center, Fayetteville, Arkansas, USA.
FAU - Li, Changwei
AU  - Li C
AD  - Department of Epidemiology, Tulane University School of Public Health and 
      Tropical Medicine, New Orleans, Louisiana, USA.
LA  - eng
GR  - R15 NR019691/NR/NINR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20210816
PL  - United States
TA  - Res Nurs Health
JT  - Research in nursing & health
JID - 7806136
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cognitive Dysfunction/*etiology/*genetics/*therapy
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Exercise/physiology
MH  - Exercise Therapy/*methods
MH  - Feasibility Studies
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
PMC - PMC8440487
MID - NIHMS1729421
OTO - NOTNLM
OT  - cognitive dysfunction
OT  - diabetes mellitus
OT  - exercise
OT  - genetic polymorphism
OT  - nursing
OT  - type 2
EDAT- 2021/08/18 06:00
MHDA- 2021/09/28 06:00
PMCR- 2022/10/01
CRDT- 2021/08/17 07:46
PHST- 2021/07/24 00:00 [revised]
PHST- 2021/03/02 00:00 [received]
PHST- 2021/07/28 00:00 [accepted]
PHST- 2021/08/18 06:00 [pubmed]
PHST- 2021/09/28 06:00 [medline]
PHST- 2021/08/17 07:46 [entrez]
PHST- 2022/10/01 00:00 [pmc-release]
AID - 10.1002/nur.22174 [doi]
PST - ppublish
SO  - Res Nurs Health. 2021 Oct;44(5):746-757. doi: 10.1002/nur.22174. Epub 2021 Aug 
      16.