PMID- 34404690
OWN - NLM
STAT- MEDLINE
DCOM- 20211004
LR  - 20230322
IS  - 1943-3654 (Electronic)
IS  - 0020-1324 (Linking)
VI  - 66
IP  - 10
DP  - 2021 Oct
TI  - Short-Term Effects of Pressure Controlled Versus Volume Controlled Noninvasive 
      Ventilation in Subjects With Amyotrophic Lateral Sclerosis.
PG  - 1593-1600
LID - 10.4187/respcare.09021 [doi]
AB  - BACKGROUND: Comparison of the effects of pressure controlled and volume 
      controlled noninvasive ventilations (NIV) has usually been limited to the degree 
      of improvement in blood gases. We compared sleep quality, abnormal respiratory 
      events, and patient-ventilator asynchronies during administration of pressure 
      controlled continuous mandatory ventilation (PC-CMV) and volume controlled 
      continuous mandatory ventilation (VC-CMV) in subjects with amyotrophic lateral 
      sclerosis naive to NIV after titration aimed at maximally improving nocturnal 
      arterial blood gases. METHODS: A crossover evaluation of PC-CMV and VC-CMV was 
      performed in 27 subjects with amyotrophic lateral sclerosis. After baseline 
      polysomnography, ventilators were set in random order so as to warrant similar 
      and satisfactory oxygen saturation and transcutaneous [Formula: see text] in both 
      NIV modalities during day and night. Soon after titration, polysomnography was 
      repeated during administration of each type of NIV. RESULTS: With respect to the 
      baseline night, non-rapid eye movement 3, and rapid eye movement sleep stages 
      increased, and the arousal index decreased during PC-CMV (P = .005, P = .02, and 
      P = .01, PC-CMV vs VC-CMV, respectively) but not during VC-CMV. The arousal index 
      during NIV was correlated to the peak pressure delivered by the ventilators (rho = 
      0.47, P < .001). Few abnormal respiratory events were observed in both NIV modes. 
      Patient-ventilator asynchronies were more frequent during VC-CMV (median [IQR] 
      20.8 [0.0 - 22.0] vs 31.8 [30.1 - 34.0] no./h, PC-CMV vs VC-CMV; P = .002). 
      Twenty-one subjects declared that they preferred PC-CMV therapy. CONCLUSIONS: In 
      the short term, PC-CMV may be a preferred NIV modality to VC-CMV for patients 
      with amyotrophic lateral sclerosis, even when both NIV modes are similarly 
      effective in the correction of hypoventilation. Evaluation of the effectiveness 
      of NIV should not be limited to the assessment of blood gas correction.
CI  - Copyright (c) 2021 by Daedalus Enterprises.
FAU - Crescimanno, Grazia
AU  - Crescimanno G
AD  - Italian National Research Council, Institute for Biomedical Research and 
      Innovation, Palermo, Italy. grazia.crescimanno@irib.cnr.it.
AD  - Regional Center for Prevention and Treatment of Respiratory Complications of Rare 
      Genetic Neuromuscular Diseases, Villa Sofia-Cervello Hospital, Palermo, Italy.
FAU - Greco, Francesca
AU  - Greco F
AD  - Italian Union Against Muscular Dystrophy, branch of Palermo, Palermo, Italy.
FAU - Bertini, Manuela
AU  - Bertini M
AD  - Regional Center for Prevention and Treatment of Respiratory Complications of Rare 
      Genetic Neuromuscular Diseases, Villa Sofia-Cervello Hospital, Palermo, Italy.
FAU - Arrisicato, Salvo
AU  - Arrisicato S
AD  - Regional Center for Prevention and Treatment of Respiratory Complications of Rare 
      Genetic Neuromuscular Diseases, Villa Sofia-Cervello Hospital, Palermo, Italy.
FAU - Marrone, Oreste
AU  - Marrone O
AD  - Italian National Research Council, Institute for Biomedical Research and 
      Innovation, Palermo, Italy.
LA  - eng
PT  - Journal Article
DEP - 20210817
PL  - United States
TA  - Respir Care
JT  - Respiratory care
JID - 7510357
SB  - IM
MH  - *Amyotrophic Lateral Sclerosis/complications/therapy
MH  - Humans
MH  - *Noninvasive Ventilation
MH  - Polysomnography
MH  - Respiration
MH  - *Respiratory Insufficiency
MH  - Sleep
OTO - NOTNLM
OT  - Pressure control continuous mandatory ventilation
OT  - Volume control continuous mandatory ventilation; amyotrophic lateral sclerosis
OT  - abnormal respiratory events
OT  - hypoventilation
OT  - patient-ventilator asynchrony
EDAT- 2021/08/19 06:00
MHDA- 2021/10/05 06:00
CRDT- 2021/08/18 05:47
PHST- 2021/08/19 06:00 [pubmed]
PHST- 2021/10/05 06:00 [medline]
PHST- 2021/08/18 05:47 [entrez]
AID - respcare.09021 [pii]
AID - 10.4187/respcare.09021 [doi]
PST - ppublish
SO  - Respir Care. 2021 Oct;66(10):1593-1600. doi: 10.4187/respcare.09021. Epub 2021 
      Aug 17.