PMID- 34404824
OWN - NLM
STAT- MEDLINE
DCOM- 20211117
LR  - 20240403
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Aug 17
TI  - Fibrinogen-Albumin-Ratio is an independent predictor of thromboembolic 
      complications in patients undergoing VA-ECMO.
PG  - 16648
LID - 10.1038/s41598-021-95689-x [doi]
LID - 16648
AB  - Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) supports patients 
      suffering from refractory cardiogenic shock. Thromboembolic complications (TeC) 
      are common in VA-ECMO patients and are associated with increased morbidity and 
      mortality. Valid markers to predict TeC in VA-ECMO patients are lacking. The 
      present study investigated the predictive value of baseline 
      Fibrinogen-Albumin-Ratio (FAR) for in-hospital TeC in patients undergoing 
      VA-ECMO. This retrospective cohort study included patients who underwent VA-ECMO 
      therapy due to cardiogenic shock at the University Hospital Duesseldorf, Germany 
      between 2011 and 2018. Main exposure was baseline FAR measured at initiation of 
      VA-ECMO therapy. The primary endpoint was the in-hospital incidence of TeC. In 
      total, 344 patients were included into analysis (74.7% male, mean age 
      59 +/- 14 years). The in-hospital incidence of TeC was 34%. Receiver operating 
      characteristics (ROC) curve of FAR for in-hospital TeC revealed an area under the 
      curve of 0.67 [95% confidence interval (CI) 0.61-0.74]. Youden index determined a 
      cutoff of 130 for baseline FAR. Multivariate logistic regression revealed an 
      adjusted odds-ratio of 3.72 [95% CI 2.26-6.14] for the association between FAR 
      and TeC. Baseline FAR is independently associated with in-hospital TeC in 
      patients undergoing VA-ECMO. Thus, FAR might contribute to the prediction of TeC 
      in this cohort.
CI  - (c) 2021. The Author(s).
FAU - Roth, Sebastian
AU  - Roth S
AD  - Department of Anesthesiology, Medical Faculty and University Hospital 
      Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225, 
      Duesseldorf, Germany.
FAU - Jansen, Catrin
AU  - Jansen C
AD  - Department of Anesthesiology, Medical Faculty and University Hospital 
      Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225, 
      Duesseldorf, Germany.
FAU - M'Pembele, Rene
AU  - M'Pembele R
AD  - Department of Anesthesiology, Medical Faculty and University Hospital 
      Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225, 
      Duesseldorf, Germany.
FAU - Stroda, Alexandra
AU  - Stroda A
AD  - Department of Anesthesiology, Medical Faculty and University Hospital 
      Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225, 
      Duesseldorf, Germany.
FAU - Boeken, Udo
AU  - Boeken U
AD  - Department of Cardiac Surgery, Medical Faculty and University Hospital 
      Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225, 
      Duesseldorf, Germany.
FAU - Akhyari, Payam
AU  - Akhyari P
AD  - Department of Cardiac Surgery, Medical Faculty and University Hospital 
      Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225, 
      Duesseldorf, Germany.
FAU - Lichtenberg, Artur
AU  - Lichtenberg A
AD  - Department of Cardiac Surgery, Medical Faculty and University Hospital 
      Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225, 
      Duesseldorf, Germany. Artur.Lichtenberg@med.uni-duesseldorf.de.
FAU - Hollmann, Markus W
AU  - Hollmann MW
AD  - Department of Anesthesiology, Amsterdam University Medical Center (AUMC), 
      Location AMC, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
FAU - Huhn, Ragnar
AU  - Huhn R
AD  - Department of Anesthesiology, Medical Faculty and University Hospital 
      Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225, 
      Duesseldorf, Germany.
FAU - Lurati Buse, Giovanna
AU  - Lurati Buse G
AD  - Department of Anesthesiology, Medical Faculty and University Hospital 
      Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225, 
      Duesseldorf, Germany.
FAU - Aubin, Hug
AU  - Aubin H
AD  - Department of Cardiac Surgery, Medical Faculty and University Hospital 
      Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225, 
      Duesseldorf, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210817
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Albumins)
RN  - 0 (Biomarkers)
RN  - 9001-32-5 (Fibrinogen)
SB  - IM
MH  - Aged
MH  - Albumins/*metabolism
MH  - Biomarkers/blood
MH  - *Extracorporeal Membrane Oxygenation
MH  - Female
MH  - Fibrinogen/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Thromboembolism/*blood
PMC - PMC8371004
COIS- The authors declare no competing interests.
EDAT- 2021/08/19 06:00
MHDA- 2021/11/18 06:00
PMCR- 2021/08/17
CRDT- 2021/08/18 06:02
PHST- 2021/06/10 00:00 [received]
PHST- 2021/07/22 00:00 [accepted]
PHST- 2021/08/18 06:02 [entrez]
PHST- 2021/08/19 06:00 [pubmed]
PHST- 2021/11/18 06:00 [medline]
PHST- 2021/08/17 00:00 [pmc-release]
AID - 10.1038/s41598-021-95689-x [pii]
AID - 95689 [pii]
AID - 10.1038/s41598-021-95689-x [doi]
PST - epublish
SO  - Sci Rep. 2021 Aug 17;11(1):16648. doi: 10.1038/s41598-021-95689-x.