PMID- 34405445
OWN - NLM
STAT- MEDLINE
DCOM- 20220510
LR  - 20220510
IS  - 1938-3673 (Electronic)
IS  - 0741-5400 (Linking)
VI  - 111
IP  - 3
DP  - 2022 Mar
TI  - Role of IL-6 in dendritic cell functions.
PG  - 695-709
LID - 10.1002/JLB.3MR0621-616RR [doi]
AB  - Dendritic cells (DCs) are efficient antigen-presenting cells that serve as a link 
      between the innate and adaptive immune systems. These cells are broadly involved 
      in cellular and humoral immune responses by presenting antigens to initiate T 
      cell reactions, cytokine and chemokine secretion, T cell differentiation and 
      expansion, B cell activation and regulation, and the mediation of immune 
      tolerance. The functions of DCs depend on their activation status, which is 
      defined by the stages of maturation, phenotype differentiation, and migration 
      ability, among other factors. IL-6 is a soluble mediator mainly produced by a 
      variety of immune cells, including DCs, that exerts pleiotropic effects on immune 
      and inflammatory responses through interaction with specific receptors expressed 
      on the surface of target cells. Here, we review the role of IL-6, when generated 
      in an inflammatory context or as derived from DCs, in modulating the biologic 
      function and activation status of DCs and emphasize the importance of searching 
      for novel strategies to target the IL-6/IL-6 signaling pathway as a means to 
      diminish the inflammatory activity of DCs in immune response or to prime the 
      immunogenic activity of DCs in immunosuppressive conditions.
CI  - (c)2021 Society for Leukocyte Biology.
FAU - Xu, Yu-Dong
AU  - Xu YD
AD  - Shanghai Research Institute of Acupuncture and Meridian, Yueyang Hospital of 
      Integrated Traditional Chinese and Western Medicine, Shanghai University of 
      Traditional Chinese Medicine, Shanghai, China.
FAU - Cheng, Mi
AU  - Cheng M
AD  - Shanghai Research Institute of Acupuncture and Meridian, Yueyang Hospital of 
      Integrated Traditional Chinese and Western Medicine, Shanghai University of 
      Traditional Chinese Medicine, Shanghai, China.
FAU - Shang, Pan-Pan
AU  - Shang PP
AD  - Shanghai Research Institute of Acupuncture and Meridian, Yueyang Hospital of 
      Integrated Traditional Chinese and Western Medicine, Shanghai University of 
      Traditional Chinese Medicine, Shanghai, China.
FAU - Yang, Yong-Qing
AU  - Yang YQ
AD  - Shanghai Research Institute of Acupuncture and Meridian, Yueyang Hospital of 
      Integrated Traditional Chinese and Western Medicine, Shanghai University of 
      Traditional Chinese Medicine, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210818
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Cell Differentiation
MH  - *Dendritic Cells
MH  - Immune Tolerance
MH  - *Interleukin-6/metabolism
MH  - Lymphocyte Activation
MH  - T-Lymphocytes
OTO - NOTNLM
OT  - IL-6
OT  - dendritic cells (DCs)
OT  - immune response
EDAT- 2021/08/19 06:00
MHDA- 2022/05/11 06:00
CRDT- 2021/08/18 06:45
PHST- 2021/08/19 06:00 [pubmed]
PHST- 2022/05/11 06:00 [medline]
PHST- 2021/08/18 06:45 [entrez]
AID - 10.1002/JLB.3MR0621-616RR [doi]
PST - ppublish
SO  - J Leukoc Biol. 2022 Mar;111(3):695-709. doi: 10.1002/JLB.3MR0621-616RR. Epub 2021 
      Aug 18.