PMID- 34405605
OWN - NLM
STAT- MEDLINE
DCOM- 20210819
LR  - 20210819
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 50
IP  - 7
DP  - 2021 Jul 8
TI  - [Clinicopathological features and molecular genetic changes of lung salivary 
      gland-type clear cell carcinoma].
PG  - 728-733
LID - 10.3760/cma.j.cn112151-20210129-00129 [doi]
AB  - Objective: To investigate the clinicopathological features, immunophenotype, 
      differential diagnosis, molecular genetic changes and prognosis of salivary 
      gland-type clear cell carcinoma (CCC) of the lung. Methods: Eight cases of 
      salivary gland-type CCC of the lung diagnosed at Fudan University Shanghai Cancer 
      Center and Shanghai Pulmonary Hospital, China from March 2017 to December 2020 
      were retrieved and analyzed. The pathological sections of these cases were 
      studied using immunohistochemical staining, fluorescence in situ hybridization 
      (FISH), and RNA-seq fusion gene detection based on next generation sequencing 
      technique. The patients were followed up and the relevant literature was 
      reviewed. Results: The 8 patients included 3 males and 5 females, with age 
      ranging from 43 to 64 years (average, 58 years). All patients underwent radical 
      lobectomy and lymph node dissection, while only one had lymph node metastases. 
      The eight patients were followed up for 6 to 45 months, and were all 
      recurrence-free. Histopathologically, the tumor was mainly composed of 
      eosinophilic and clear cells arranged in trabecular, ribbon and nest patterns. 
      Hyalinization was often observed in the stroma around the nest. 
      Immunohistochemical staining showed that 8/8 cases were positive for EMA and CK7; 
      5/8 cases were positive for p63 and p40; 4/8 cases were positive for SOX10; and 
      the cases were all negative for S-100, SMA and calponin. EWSR1 gene fusion was 
      detected in all cases by FISH. RNA-seq fusion gene was detected in 6 cases based 
      on next generation sequencing. The EWSR1-ATF1 gene fusion was detected in 5 
      cases, among which one case also had the ATF1-SPTLC2 gene fusion. All 5 cases 
      with EWSR1-ATF1 gene fusion showed that EWSR1 exon 12/13 fused with ATF1 exon 3. 
      And EWSR1-CREM gene fusion was detected in one case. Conclusions: Salivary 
      gland-type CCC of the lung is an extremely rare primary lung tumor arising from 
      the bronchial mucosa. The diagnosis and differential diagnosis of this tumor 
      depend on classic histomorphology, especially the auxiliary detection of EWSR1 
      fusion gene. The primary treatment choice of this tumor is complete surgical 
      resection. Lymph node metastases may occur, but the overall prognosis is good.
FAU - Xue, Q Q
AU  - Xue QQ
AD  - Department of Pathology, Fudan University Shanghai Cancer Center; Department of 
      Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
FAU - Huang, Y
AU  - Huang Y
AD  - Department of Pathology, Tongji University Shanghai Pulmonary Hospital, Shanghai 
      200433, China.
FAU - Zuo, S Y
AU  - Zuo SY
AD  - Department of Pathology, the Second People's Hospital of Liaocheng, Shandong 
      Province, Liaocheng 252600, China.
FAU - Zheng, Q
AU  - Zheng Q
AD  - Department of Pathology, Fudan University Shanghai Cancer Center; Department of 
      Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
FAU - Ji, G
AU  - Ji G
AD  - Department of Pathology, Fudan University Shanghai Cancer Center; Department of 
      Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
FAU - Zhou, X Y
AU  - Zhou XY
AD  - Department of Pathology, Fudan University Shanghai Cancer Center; Department of 
      Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
FAU - Wu, C Y
AU  - Wu CY
AD  - Department of Pathology, Tongji University Shanghai Pulmonary Hospital, Shanghai 
      200433, China.
FAU - Li, Y
AU  - Li Y
AD  - Department of Pathology, Fudan University Shanghai Cancer Center; Department of 
      Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
LA  - chi
GR  - 81972171/National Natural Science Foundation of China/
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (RNA-Binding Protein EWS)
SB  - IM
MH  - Adult
MH  - Biomarkers, Tumor
MH  - *Carcinoma
MH  - China
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lung
MH  - Male
MH  - Middle Aged
MH  - Molecular Biology
MH  - RNA-Binding Protein EWS/genetics
MH  - Salivary Glands
EDAT- 2021/08/19 06:00
MHDA- 2021/08/20 06:00
CRDT- 2021/08/18 07:04
PHST- 2021/08/18 07:04 [entrez]
PHST- 2021/08/19 06:00 [pubmed]
PHST- 2021/08/20 06:00 [medline]
AID - 10.3760/cma.j.cn112151-20210129-00129 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2021 Jul 8;50(7):728-733. doi: 
      10.3760/cma.j.cn112151-20210129-00129.