PMID- 34405615
OWN - NLM
STAT- MEDLINE
DCOM- 20210819
LR  - 20210819
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 50
IP  - 7
DP  - 2021 Jul 8
TI  - [Translocations of MYC, bcl-2 and bcl-6 genes and Epstein-Barr virus infection in 
      primary cardiac large B-cell lymphoma].
PG  - 785-790
LID - 10.3760/cma.j.cn112151-20201207-00908 [doi]
AB  - Objective: To investigate the translocations of MYC, bcl-2 and bcl-6 genes, the 
      Epstein-Barr virus (EBV) status and the clinicopathological features of primary 
      cardiac large B cell lymphoma (LBCL). Methods: Seven cases of primary cardiac 
      LBCL were collected at Beijing Friendship Hospital, Capital Medical University, 
      China from February 2013 to May 2019. The clinical feature, pathological 
      morphology and immunophenotype were analyzed. The detections of EBV and gene 
      rearrangements of MYC, bcl-2 and bcl-6 were conducted. The 2017 WHO 
      classification of tumors of haematopoietic and lymphoid tissues was used to 
      classify the tumors. Results: Four patients with right atrial lesions showed 
      diffuse infiltration of medium size lymphoid cells with small vascular 
      hyperplasia, without evidence of EBV infection. Without detectable gene 
      rearrangements of MYC and bcl-2, 2 of the patients showed bcl-6 gene break-apart. 
      The diagnosis was revised from diffuse LBCL to high-grade B-cell lymphoma, not 
      otherwise specified (HGBL-NOS). There was a case of CD5(+) diffuse LBCL involving 
      the right atrium and ventricle and 2 cases of fibrin-associated diffuse LBCL 
      located at left atrium without gene rearrangements of MYC, bcl-2 and bcl-6. 
      However, EBER and EBNA2 were highly expressed in fibrin-associated diffuse LBCL. 
      The patients were followed up for 10-71 months. Four cases of HGBL-NOS and a case 
      of CD5(+) diffuse LBCL received R-CHOP with/without autologous stem cell 
      transplantation. All but two patients survived. Two cases of fibrin-associated 
      diffuse LBCL were disease free without adjuvant chemotherapy and radiotherapy. 
      Conclusions: Primary cardiac LBCL is heterogeneous, including at least HGBL-NOS. 
      Primary cardiac HGBL-NOS most frequently occurs in the right atrium. Tumor cells 
      of primary cardiac LBCL have the morphological characteristics similar to Burkitt 
      lymphoma, lacking MYC and bcl-2 gene rearrangements, but usually show bcl-6 gene 
      disruption. Fibrin-associated diffuse LBCL has a good prognosis and postoperative 
      chemotherapy seems unnecessary.
FAU - Xie, J L
AU  - Xie JL
AD  - Department of Pathology, Beijing Friendship Hospital, Capital Medical University, 
      Beijing 100050, China.
FAU - Teng, X J
AU  - Teng XJ
AD  - Department of Pathology, Beijing Friendship Hospital, Capital Medical University, 
      Beijing 100050, China.
FAU - Zheng, Y Y
AU  - Zheng YY
AD  - Department of Pathology, Beijing Friendship Hospital, Capital Medical University, 
      Beijing 100050, China.
FAU - Zhang, Y L
AU  - Zhang YL
AD  - Department of Pathology, Beijing Friendship Hospital, Capital Medical University, 
      Beijing 100050, China.
FAU - Zhou, X G
AU  - Zhou XG
AD  - Department of Pathology, Beijing Friendship Hospital, Capital Medical University, 
      Beijing 100050, China.
LA  - chi
GR  - 2018-1-2151/Special Program for Capital Hygiene Development/
PT  - Case Reports
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
SB  - IM
MH  - *Epstein-Barr Virus Infections/genetics
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Herpesvirus 4, Human/genetics
MH  - Humans
MH  - *Lymphoma, Large B-Cell, Diffuse/genetics
MH  - Proto-Oncogene Proteins c-bcl-2/genetics
MH  - Transplantation, Autologous
EDAT- 2021/08/19 06:00
MHDA- 2021/08/20 06:00
CRDT- 2021/08/18 07:04
PHST- 2021/08/18 07:04 [entrez]
PHST- 2021/08/19 06:00 [pubmed]
PHST- 2021/08/20 06:00 [medline]
AID - 10.3760/cma.j.cn112151-20201207-00908 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2021 Jul 8;50(7):785-790. doi: 
      10.3760/cma.j.cn112151-20201207-00908.