PMID- 34407939
OWN - NLM
STAT- MEDLINE
DCOM- 20220415
LR  - 20220415
IS  - 2375-2548 (Electronic)
IS  - 2375-2548 (Linking)
VI  - 7
IP  - 34
DP  - 2021 Aug
TI  - Theta oscillations synchronize human medial prefrontal cortex and amygdala during 
      fear learning.
LID - 10.1126/sciadv.abf4198 [doi]
LID - eabf4198
AB  - Numerous animal studies have demonstrated that fear acquisition and expression 
      rely on the coordinated activity of medial prefrontal cortex (mPFC) and amygdala 
      and that theta oscillations support interregional communication within the fear 
      network. However, it remains unclear whether these results can be generalized to 
      fear learning in humans. We addressed this question using intracranial 
      electroencephalography recordings in 13 patients with epilepsy during a fear 
      conditioning paradigm. We observed increased power and inter-regional 
      synchronization of amygdala and mPFC in theta (4 to 8 hertz) oscillations for 
      conditioned stimulus (CS+) versus CS-. Analysis of information flow revealed that 
      the dorsal mPFC (dmPFC) led amygdala activity in theta oscillations. Last, a 
      computational model showed that trial-by-trial changes in amygdala theta 
      oscillations predicted the model-based associability (i.e., learning rate). This 
      study provides compelling evidence that theta oscillations within and between 
      amygdala, ventral mPFC, and dmPFC constitute a general mechanism of fear learning 
      across species.
CI  - Copyright (c) 2021 The Authors, some rights reserved; exclusive licensee American 
      Association for the Advancement of Science. No claim to original U.S. Government 
      Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 
      (CC BY-NC).
FAU - Chen, Si
AU  - Chen S
AUID- ORCID: 0000-0001-6631-2179
AD  - CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.
AD  - Department of Psychology, University of Chinese Academy of Sciences, Beijing, 
      China.
FAU - Tan, Zheng
AU  - Tan Z
AD  - CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.
AD  - Department of Psychology, University of Chinese Academy of Sciences, Beijing, 
      China.
FAU - Xia, Wenran
AU  - Xia W
AD  - CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.
AD  - Department of Psychology, University of Chinese Academy of Sciences, Beijing, 
      China.
FAU - Gomes, Carlos Alexandre
AU  - Gomes CA
AD  - Department of Neuropsychology, Institute of Cognitive Neuroscience, Faculty of 
      Psychology, Ruhr University Bochum, Bochum, Germany.
FAU - Zhang, Xilei
AU  - Zhang X
AUID- ORCID: 0000-0003-3474-2339
AD  - CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.
FAU - Zhou, Wenjing
AU  - Zhou W
AUID- ORCID: 0000-0002-7272-6236
AD  - Epilepsy Center, Tsinghua University Yuquan Hospital, Beijing, China.
FAU - Liang, Shuli
AU  - Liang S
AD  - Functional Neurosurgery Department, Beijing Children's Hospital, Capital Medical 
      University, Beijing, China.
FAU - Axmacher, Nikolai
AU  - Axmacher N
AUID- ORCID: 0000-0002-0475-6492
AD  - Department of Neuropsychology, Institute of Cognitive Neuroscience, Faculty of 
      Psychology, Ruhr University Bochum, Bochum, Germany.
AD  - State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern 
      Institute for Brain Research, Beijing Normal University, Xinjiekouwai Street 19, 
      Beijing 100875, China.
FAU - Wang, Liang
AU  - Wang L
AUID- ORCID: 0000-0001-9434-7571
AD  - CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China. 
      lwang@psych.ac.cn.
AD  - Department of Psychology, University of Chinese Academy of Sciences, Beijing, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210818
PL  - United States
TA  - Sci Adv
JT  - Science advances
JID - 101653440
SB  - IM
MH  - *Amygdala
MH  - Animals
MH  - Conditioning, Classical
MH  - *Extinction, Psychological
MH  - Fear
MH  - Humans
MH  - Prefrontal Cortex
PMC - PMC8373137
EDAT- 2021/08/20 06:00
MHDA- 2022/04/16 06:00
PMCR- 2021/08/18
CRDT- 2021/08/19 05:53
PHST- 2020/10/28 00:00 [received]
PHST- 2021/06/29 00:00 [accepted]
PHST- 2021/08/19 05:53 [entrez]
PHST- 2021/08/20 06:00 [pubmed]
PHST- 2022/04/16 06:00 [medline]
PHST- 2021/08/18 00:00 [pmc-release]
AID - 7/34/eabf4198 [pii]
AID - abf4198 [pii]
AID - 10.1126/sciadv.abf4198 [doi]
PST - epublish
SO  - Sci Adv. 2021 Aug 18;7(34):eabf4198. doi: 10.1126/sciadv.abf4198. Print 2021 Aug.