PMID- 34408050
OWN - NLM
STAT- MEDLINE
DCOM- 20210827
LR  - 20210903
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 11
IP  - 8
DP  - 2021 Aug 18
TI  - Exposure to persistent organic pollutants and thyroid cancer risk: a study 
      protocol of systematic review and meta-analysis.
PG  - e048451
LID - 10.1136/bmjopen-2020-048451 [doi]
LID - e048451
AB  - INTRODUCTION: The thyroid cancer incidence has been increasing all over the 
      world. However, the aetiology of thyroid cancer remains unclear. A growing body 
      of evidence suggested exposure to persistent organic pollutants (POPs) may play a 
      role in the initiation of thyroid cancer, but the results are generally 
      inconsistent across studies. This review aims to synthesise the evidence for the 
      health effects of POPs on the risk of thyroid cancer. METHODS AND ANALYSIS: This 
      protocol was reported in accordance to the Preferred Reporting Items for 
      Systematic Reviews and Meta-Analyses Protocols (PRISMA) statements. A 
      comprehensive search, including electronic database search (eg, PubMed, Embase, 
      ProQuest and CNKI), website search and manual search, will be performed to 
      identify all eligible studies. The Population, Exposure, Comparator and Outcome 
      framework was used to clarify the inclusion and exclusion criteria. The 
      Newcastle-Ottawa Scale will be used to assess the quality of included studies. 
      Maximally adjusted effect estimates from individual studies will be summarised 
      with random-effect models in a conservative manner. I(2) statistics and Q-tests 
      will be used to test the heterogeneity across studies. We will perform extensive 
      sensitivity analyses, such as confounding risk ratio (confounding), E-value, 
      fixed-effect models, excluding the most relatively weighted study, including only 
      the high-quality studies and many predesigned subgroup analyses, etc. The 
      findings will be reported in accordance to the PRISMA guidelines. ETHICS AND 
      DISSEMINATION: Ethical approval is not required in this systematic review of 
      published literatures. The results will be published in a peer-reviewed journal 
      and presented at relevant conferences. PROSPERO REGISTRATION NUMBER: 
      CRD42020181343.
CI  - (c) Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Zhang, Yu Xue
AU  - Zhang YX
AD  - Department of Preventive Medicine, School of Public Health, Harbin Medical 
      University, Harbin, Heilongjiang, China.
FAU - Liu, Yu Peng
AU  - Liu YP
AD  - Department of Epidemiology and Biostatistics, School of Public Health and 
      Management, Wenzhou Medical University, Wenzhou, China.
FAU - Miao, Su Sheng
AU  - Miao SS
AD  - Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, 
      Harbin, Heilongjiang, China.
FAU - Liu, Xiao Dong
AU  - Liu XD
AUID- ORCID: 0000-0002-6879-990X
AD  - Department of Occupational and Environmental Health, School of Public Health and 
      Management, Wenzhou Medical University, Wenzhou, China.
FAU - Ma, Shu Mei
AU  - Ma SM
AD  - Department of Occupational and Environmental Health, School of Public Health and 
      Management, Wenzhou Medical University, Wenzhou, China.
FAU - Qu, Zhang Yi
AU  - Qu ZY
AUID- ORCID: 0000-0002-6703-813X
AD  - Department of Hygiene Microbiology, School of Public Health, Harbin Medical 
      University, Harbin, Heilongjiang, China quzy_hmu@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210818
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
SB  - IM
MH  - Humans
MH  - Incidence
MH  - Meta-Analysis as Topic
MH  - *Persistent Organic Pollutants
MH  - Qualitative Research
MH  - Systematic Reviews as Topic
MH  - *Thyroid Neoplasms/chemically induced/epidemiology
PMC - PMC8375755
OTO - NOTNLM
OT  - endocrine tumours
OT  - epidemiology
OT  - public health
OT  - thyroid disease
COIS- Competing interests: None declared.
EDAT- 2021/08/20 06:00
MHDA- 2021/08/28 06:00
PMCR- 2021/08/18
CRDT- 2021/08/19 05:55
PHST- 2021/08/19 05:55 [entrez]
PHST- 2021/08/20 06:00 [pubmed]
PHST- 2021/08/28 06:00 [medline]
PHST- 2021/08/18 00:00 [pmc-release]
AID - bmjopen-2020-048451 [pii]
AID - 10.1136/bmjopen-2020-048451 [doi]
PST - epublish
SO  - BMJ Open. 2021 Aug 18;11(8):e048451. doi: 10.1136/bmjopen-2020-048451.