PMID- 34408175
OWN - NLM
STAT- MEDLINE
DCOM- 20211111
LR  - 20211111
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Aug 18
TI  - Improvement of quality of life and symptom burden after robot-assisted radical 
      prostatectomy in patients with moderate to severe LUTS.
PG  - 16757
LID - 10.1038/s41598-021-95525-2 [doi]
LID - 16757
AB  - The aim of this study was to assess clinically meaningful differences of 
      preoperative lower urinary tract symptoms (LUTS) and quality of life (QoL) before 
      and after robot-assisted radical prostatectomy (RARP). Therefore we identified 
      5506 RARP patients from 2007 to 2018 with completed International Prostate 
      Symptom Score (IPSS) and -QoL questionnaires before and 12 months after RARP in 
      our institution. Marked clinically important difference (MCID) was defined by 
      using the strictest IPSS-difference of - 8 points. Multivariable logistic 
      regression analyses (LRM) aimed to predict ∆IPSS </= - 8 and were restricted to 
      RARP patients with preoperatively moderate (IPSS 8-19) vs. severe (IPSS 20-35) 
      LUTS burden (n = 2305). Preoperative LUTS was categorized as moderate and severe 
      in 37% (n = 2014) and 5.3% of the complete cohort (n = 291), respectively. Here, 
      a postoperative ∆IPSS </= - 8, was reported in 38% vs. 90%. In LRM, younger age (OR 
      0.98, 95%CI 0.97-0.99; p = 0.007), lower BMI (OR 0.94, 95%CI 0.92-0.97; 
      p < 0.001), higher preoperative LUTS burden (severe vs. moderate [REF.] OR 15.6, 
      95%CI 10.4-23.4; p < 0.001), greater prostate specimen weight (per 10 g, OR 1.12, 
      95%CI 1.07-1.16; p < 0.001) and the event of urinary continence recovery (OR 1.66 
      95%CI 1.25-2.21; p < 0.001) were independent predictors of a marked LUTS 
      improvement after RARP. Less rigorous IPSS-difference of - 5 points yielded 
      identical predictors. To sum up, in substantial proportions of patients with 
      preoperative moderate or severe LUTS a marked improvement of LUTS and QoL can be 
      expected at 12 months after RARP. LRM revealed greatest benefit in those patients 
      with preoperatively greatest LUTS burden, prostate enlargement, lower BMI, 
      younger age and the event of urinary continence recovery.
CI  - (c) 2021. The Author(s).
FAU - Leyh-Bannurah, Sami-Ramzi
AU  - Leyh-Bannurah SR
AD  - Prostate Center Northwest, Department of Urology, Pediatric Urology and 
      Uro-Oncology, St. Antonius-Hospital, Gronau, Germany.
FAU - Wagner, Christian
AU  - Wagner C
AD  - Prostate Center Northwest, Department of Urology, Pediatric Urology and 
      Uro-Oncology, St. Antonius-Hospital, Gronau, Germany.
FAU - Schuette, Andreas
AU  - Schuette A
AD  - Prostate Center Northwest, Department of Urology, Pediatric Urology and 
      Uro-Oncology, St. Antonius-Hospital, Gronau, Germany.
FAU - Liakos, Nikolaos
AU  - Liakos N
AD  - Prostate Center Northwest, Department of Urology, Pediatric Urology and 
      Uro-Oncology, St. Antonius-Hospital, Gronau, Germany.
FAU - Karagiotis, Theodoros
AU  - Karagiotis T
AD  - Prostate Center Northwest, Department of Urology, Pediatric Urology and 
      Uro-Oncology, St. Antonius-Hospital, Gronau, Germany.
FAU - Mendrek, Mikolaj
AU  - Mendrek M
AD  - Prostate Center Northwest, Department of Urology, Pediatric Urology and 
      Uro-Oncology, St. Antonius-Hospital, Gronau, Germany.
FAU - Rachubinski, Pawel
AU  - Rachubinski P
AD  - Prostate Center Northwest, Department of Urology, Pediatric Urology and 
      Uro-Oncology, St. Antonius-Hospital, Gronau, Germany.
FAU - Urbanova, Katarina
AU  - Urbanova K
AD  - Prostate Center Northwest, Department of Urology, Pediatric Urology and 
      Uro-Oncology, St. Antonius-Hospital, Gronau, Germany.
FAU - Oelke, Matthias
AU  - Oelke M
AD  - Prostate Center Northwest, Department of Urology, Pediatric Urology and 
      Uro-Oncology, St. Antonius-Hospital, Gronau, Germany.
FAU - Witt, Jorn H
AU  - Witt JH
AD  - Prostate Center Northwest, Department of Urology, Pediatric Urology and 
      Uro-Oncology, St. Antonius-Hospital, Gronau, Germany. witt@stantonius-gronau.de.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210818
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Aged
MH  - Follow-Up Studies
MH  - Humans
MH  - Lower Urinary Tract Symptoms/*surgery
MH  - Male
MH  - Middle Aged
MH  - *Prostatectomy
MH  - *Quality of Life
MH  - *Robotic Surgical Procedures
PMC - PMC8373967
COIS- The authors declare no competing interests.
EDAT- 2021/08/20 06:00
MHDA- 2021/11/12 06:00
PMCR- 2021/08/18
CRDT- 2021/08/19 06:07
PHST- 2021/04/28 00:00 [received]
PHST- 2021/07/23 00:00 [accepted]
PHST- 2021/08/19 06:07 [entrez]
PHST- 2021/08/20 06:00 [pubmed]
PHST- 2021/11/12 06:00 [medline]
PHST- 2021/08/18 00:00 [pmc-release]
AID - 10.1038/s41598-021-95525-2 [pii]
AID - 95525 [pii]
AID - 10.1038/s41598-021-95525-2 [doi]
PST - epublish
SO  - Sci Rep. 2021 Aug 18;11(1):16757. doi: 10.1038/s41598-021-95525-2.