PMID- 34409027
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231107
IS  - 2296-634X (Print)
IS  - 2296-634X (Electronic)
IS  - 2296-634X (Linking)
VI  - 9
DP  - 2021
TI  - The Actin Cytoskeleton at the Immunological Synapse of Dendritic Cells.
PG  - 679500
LID - 10.3389/fcell.2021.679500 [doi]
LID - 679500
AB  - Dendritic cells (DCs) are considered the most potent antigen-presenting cells. 
      DCs control the activation of T cells (TCs) in the lymph nodes. This process 
      involves forming a specialized superstructure at the DC-TC contact zone called 
      the immunological synapse (IS). For the sake of clarity, we call IS(DC) and 
      IS(TC) the DC and TC sides of the IS, respectively. The IS(DC) and IS(TC) seem to 
      organize as multicentric signaling hubs consisting of surface proteins, including 
      adhesion and costimulatory molecules, associated with cytoplasmic components, 
      which comprise cytoskeletal proteins and signaling molecules. Most of the studies 
      on the IS have focused on the IS(TC), and the information on the IS(DC) is still 
      sparse. However, the data available suggest that both IS sides are involved in 
      the control of TC activation. The IS(DC) may govern activities of DCs that confer 
      them the ability to activate the TCs. One key component of the IS(DC) is the 
      actin cytoskeleton. Herein, we discuss experimental data that support the concept 
      that actin polarized at the IS(DC) is essential to maintaining IS stability 
      necessary to induce TC activation.
CI  - Copyright (c) 2021 Rodriguez-Fernandez and Criado-Garcia.
FAU - Rodriguez-Fernandez, Jose Luis
AU  - Rodriguez-Fernandez JL
AD  - Department of Cellular and Molecular Biology, Centro de Investigaciones 
      Biologicas Margarita Salas, Consejo Superior de Investigaciones Cientificas, 
      Madrid, Spain.
FAU - Criado-Garcia, Olga
AU  - Criado-Garcia O
AD  - Department of Cellular and Molecular Biology, Centro de Investigaciones 
      Biologicas Margarita Salas, Consejo Superior de Investigaciones Cientificas, 
      Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210802
PL  - Switzerland
TA  - Front Cell Dev Biol
JT  - Frontiers in cell and developmental biology
JID - 101630250
PMC - PMC8366227
OTO - NOTNLM
OT  - T cell activation
OT  - actin
OT  - cytoskeleton
OT  - dendritic cell
OT  - immunological synapse
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/08/20 06:00
MHDA- 2021/08/20 06:01
PMCR- 2021/01/01
CRDT- 2021/08/19 06:44
PHST- 2021/03/11 00:00 [received]
PHST- 2021/07/05 00:00 [accepted]
PHST- 2021/08/19 06:44 [entrez]
PHST- 2021/08/20 06:00 [pubmed]
PHST- 2021/08/20 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fcell.2021.679500 [doi]
PST - epublish
SO  - Front Cell Dev Biol. 2021 Aug 2;9:679500. doi: 10.3389/fcell.2021.679500. 
      eCollection 2021.