PMID- 34410389
OWN - NLM
STAT- MEDLINE
DCOM- 20220331
LR  - 20221207
IS  - 1759-6653 (Electronic)
IS  - 1759-6653 (Linking)
VI  - 13
IP  - 9
DP  - 2021 Sep 1
TI  - Whole-Genome Sequencing of a 900-Year-Old Human Skeleton Supports Two Past 
      Migration Events from the Russian Far East to Northern Japan.
LID - 10.1093/gbe/evab192 [doi]
LID - evab192
AB  - Recent studies on paleogenomics have reported some Paleolithic and Neolithic 
      genomes that have provided new insights into the human population history in East 
      and Northeast Asia. However, there remain some cases where more recent migration 
      events need to be examined to elucidate the detailed formation process of local 
      populations. Although the area around northern Japan is one of the regions 
      archaeologically suggested to have been affected by migration waves after the 
      Neolithic period, the genetic source of these migrations are still unclear. Thus, 
      genomic data from such past migrant populations would be highly informative to 
      clarify the detailed formation process of local populations in this region. Here, 
      we report the genome sequence of a 900-year-old adult female (NAT002) belonging 
      to the prehistoric Okhotsk people, who have been considered to be the past 
      migrants to northern Japan after the Neolithic period. We found a close 
      relationship between NAT002 and modern Lower Amur populations and past admixture 
      events between the Amur, Jomon, and Kamchatka ancestries. The admixture dating 
      suggested migration of Amur-related ancestry at approximately 1,600 BP, which is 
      compatible with the archaeological evidence regarding the settlement of the 
      Okhotsk people. Our results also imply migration of Kamchatka-related ancestry at 
      approximately 2,000 BP. In addition, human leukocyte antigen (HLA) typing 
      detected the HLA-B*40 allele, which is reported to increase the risk of 
      arthritis, suggesting the genetic vulnerability of NAT002 to hyperostosis, which 
      was observed around her chest clavicle.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      Society for Molecular Biology and Evolution.
FAU - Sato, Takehiro
AU  - Sato T
AUID- ORCID: 0000-0001-9866-0346
AD  - Department of Human Biology and Anatomy, Graduate School of Medicine, University 
      of the Ryukyus, Nishihara, Japan.
AD  - Department of Bioinformatics and Genomics, Graduate School of Medical Sciences, 
      Kanazawa University, Kanazawa, Japan.
FAU - Adachi, Noboru
AU  - Adachi N
AD  - Department of Legal Medicine, Graduate School of Medicine, University of 
      Yamanashi, Chuo, Japan.
FAU - Kimura, Ryosuke
AU  - Kimura R
AUID- ORCID: 0000-0003-0100-273X
AD  - Department of Human Biology and Anatomy, Graduate School of Medicine, University 
      of the Ryukyus, Nishihara, Japan.
FAU - Hosomichi, Kazuyoshi
AU  - Hosomichi K
AD  - Department of Bioinformatics and Genomics, Graduate School of Medical Sciences, 
      Kanazawa University, Kanazawa, Japan.
FAU - Yoneda, Minoru
AU  - Yoneda M
AD  - The University Museum, The University of Tokyo, Tokyo, Japan.
FAU - Oota, Hiroki
AU  - Oota H
AUID- ORCID: 0000-0003-0746-2729
AD  - Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Japan.
AD  - Department of Biological Sciences, Graduate School of Science, The University of 
      Tokyo, Tokyo, Japan.
FAU - Tajima, Atsushi
AU  - Tajima A
AUID- ORCID: 0000-0001-6808-5491
AD  - Department of Bioinformatics and Genomics, Graduate School of Medical Sciences, 
      Kanazawa University, Kanazawa, Japan.
FAU - Toyoda, Atsushi
AU  - Toyoda A
AD  - Comparative Genomics Laboratory, National Institute of Genetics, Mishima, Japan.
FAU - Kanzawa-Kiriyama, Hideaki
AU  - Kanzawa-Kiriyama H
AD  - Department of Anthropology, National Museum of Nature and Science, Tsukuba, 
      Japan.
FAU - Matsumae, Hiromi
AU  - Matsumae H
AD  - Kihara Institute for Biological Research (KIBR), Yokohama City University, 
      Yokohama, Japan.
AD  - Department of Molecular Life Science, School of Medicine, Tokai University, 
      Isehara, Japan.
FAU - Koganebuchi, Kae
AU  - Koganebuchi K
AUID- ORCID: 0000-0002-6972-2218
AD  - Department of Biological Sciences, Graduate School of Science, The University of 
      Tokyo, Tokyo, Japan.
AD  - Department of Biological Structure, Kitasato University Graduate School of 
      Medical Sciences, Sagamihara, Japan.
AD  - Advanced Medical Research Center, Faculty of Medicine, University of the Ryukyus, 
      Nishihara, Japan.
FAU - Shimizu, Kentaro K
AU  - Shimizu KK
AUID- ORCID: 0000-0002-6483-1781
AD  - Kihara Institute for Biological Research (KIBR), Yokohama City University, 
      Yokohama, Japan.
AD  - Department of Evolutionary Biology and Environmental Studies, University of 
      Zurich, Zurich, Switzerland.
FAU - Shinoda, Ken-Ichi
AU  - Shinoda KI
AD  - Department of Anthropology, National Museum of Nature and Science, Tsukuba, 
      Japan.
FAU - Hanihara, Tsunehiko
AU  - Hanihara T
AD  - Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Japan.
FAU - Weber, Andrzej
AU  - Weber A
AD  - Department of Anthropology, University of Alberta, Edmonton, Alberta, Canada.
AD  - Research Centre "Baikal Region", Irkutsk State University, Irkutsk, Russia.
AD  - Laboratoire Mediterraneen de Prehistoire Europe Afrique (LAMPEA) - UMR 7269, 
      Aix-Marseille Universite, Aix-en-Provence, France.
FAU - Kato, Hirofumi
AU  - Kato H
AD  - Centre for Ainu and Indigenous Studies, Hokkaido University, Sapporo, Japan.
FAU - Ishida, Hajime
AU  - Ishida H
AD  - Department of Human Biology and Anatomy, Graduate School of Medicine, University 
      of the Ryukyus, Nishihara, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Genome Biol Evol
JT  - Genome biology and evolution
JID - 101509707
SB  - IM
MH  - Asia, Eastern
MH  - Female
MH  - *Genome, Human
MH  - *Genomics
MH  - Human Migration
MH  - Humans
MH  - Japan
MH  - Paleontology
MH  - Skeleton
PMC - PMC8449830
OTO - NOTNLM
OT  - admixture dating
OT  - ancient genomics
OT  - next-generation sequencing
OT  - population history
OT  - prehistoric Okhotsk people
EDAT- 2021/08/20 06:00
MHDA- 2022/04/01 06:00
PMCR- 2021/08/19
CRDT- 2021/08/19 12:21
PHST- 2021/08/15 00:00 [accepted]
PHST- 2021/08/20 06:00 [pubmed]
PHST- 2022/04/01 06:00 [medline]
PHST- 2021/08/19 12:21 [entrez]
PHST- 2021/08/19 00:00 [pmc-release]
AID - 6355032 [pii]
AID - evab192 [pii]
AID - 10.1093/gbe/evab192 [doi]
PST - ppublish
SO  - Genome Biol Evol. 2021 Sep 1;13(9):evab192. doi: 10.1093/gbe/evab192.