PMID- 34414227
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210821
IS  - 2297-1769 (Print)
IS  - 2297-1769 (Electronic)
IS  - 2297-1769 (Linking)
VI  - 8
DP  - 2021
TI  - Agreement of Bioreactance Cardiac Output Monitoring With Thermodilution in 
      Healthy Standing Horses.
PG  - 701339
LID - 10.3389/fvets.2021.701339 [doi]
LID - 701339
AB  - Bioreactance is the continuous analysis of transthoracic voltage variation in 
      response to an applied high frequency transthoracic current and was recently 
      introduced for non-invasive cardiac output measurement (NICOM). We evaluated 
      NICOM compared to thermodilution (TD) in adult horses. Six healthy horses were 
      used for this prospective, blinded, experimental study. Cardiac output (CO) 
      measurements were performed simultaneously using TD and the bioreactance method. 
      Different cardiac output scenarios were established using xylazine (0.5 mg/kg IV) 
      and dobutamine (1.5-3 mcg/kg/min). Statistical analysis was performed by 
      calculating the concordance rate, performing a regression analysis, Pearson 
      correlation, and Bland Altman. The TD-based CO and NICOM values were highly 
      correlated for low, normal and high CO values with an overall correlation 
      coefficient. A 4-quadrant plot showed an 89% rate of concordance. The linear 
      regression calculated a relationship between NICOM and TDCO of Y = 0.4874 . X + 
      0.5936. For the corrected Bland Altman agreement, the mean bias and lower/upper 
      limits of agreement were -0.26 and -3.88 to 3.41 L/min, respectively. Compared to 
      TD, bioreactance- based NICOM showed good accuracy at induced low, normal, and 
      high CO states in normal horses. Future studies performed under more clinical 
      conditions will show if this monitor can help to assess hemodynamic status and 
      guide therapy in horses in ICU settings and under general anesthesia.
CI  - Copyright (c) 2021 Hopster and Hurcombe.
FAU - Hopster, Klaus
AU  - Hopster K
AD  - Department of Clinical Studies, School of Veterinary Medicine, University of 
      Pennsylvania, Philadelphia, PA, United States.
FAU - Hurcombe, Samuel D A
AU  - Hurcombe SDA
AD  - Department of Clinical Studies, School of Veterinary Medicine, University of 
      Pennsylvania, Philadelphia, PA, United States.
LA  - eng
PT  - Journal Article
DEP - 20210803
PL  - Switzerland
TA  - Front Vet Sci
JT  - Frontiers in veterinary science
JID - 101666658
PMC - PMC8369349
OTO - NOTNLM
OT  - bioimpedance
OT  - dobutamine
OT  - equine
OT  - flow
OT  - hemodynamic
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/08/21 06:00
MHDA- 2021/08/21 06:01
PMCR- 2021/01/01
CRDT- 2021/08/20 07:07
PHST- 2021/04/29 00:00 [received]
PHST- 2021/07/12 00:00 [accepted]
PHST- 2021/08/20 07:07 [entrez]
PHST- 2021/08/21 06:00 [pubmed]
PHST- 2021/08/21 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fvets.2021.701339 [doi]
PST - epublish
SO  - Front Vet Sci. 2021 Aug 3;8:701339. doi: 10.3389/fvets.2021.701339. eCollection 
      2021.