PMID- 34414939
OWN - NLM
STAT- MEDLINE
DCOM- 20210902
LR  - 20210902
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 100
IP  - 33
DP  - 2021 Aug 20
TI  - Elevated homocysteine levels in patients with heart failure: A systematic review 
      and meta-analysis.
PG  - e26875
LID - 10.1097/MD.0000000000026875 [doi]
LID - e26875
AB  - BACKGROUND: Elevated homocysteine (Hcy) levels showed increasing significance as 
      the predisposing factor for the pathogenesis of atherosclerotic sequelae, 
      including cardiovascular mortality, coronary artery disease, and stroke. There is 
      increasing evidence linking plasma Hcy levels and heart failure (HF). The 
      association between the elevated level of plasma Hcy and HF was examined by 
      meta-analysis and systematic review in this study. METHODS: The PubMed and 
      ScienceDirect databases until April 2020 were utilized to collect previous 
      literature on plasma Hcy levels and the potential relation to HF. The pooled 
      effects were evaluated depending on standardized mean differences (SMDs) with 95% 
      confidence intervals (CIs), and the calculation was performed using Stata 12 
      software. Potential sources of heterogeneity were assessed with subgroup analysis 
      and sensitivity analysis. RESULTS: A total of 12 research projects including 5506 
      subjects were selected. For pooled effect, the results confirmed that patients 
      with HF had higher Hcy levels than the control subjects (SMD,1.148 and 95%CI, 
      [0.715, 1.581]). Based on the classification of New York Heart Association 
      (NYHA), the Hcy levels for the group of NYHA I or II (SMD, 1.484 and 95% CI, 
      [0.442, 2.527]) and the group of NYHA III or IV (SMD, 3.361 and 95% CI, [1.902, 
      4.820]) were significantly increased compared to controls, while the increase was 
      more intensive for the group of NYHA III or IV. Subgroup analyses revealed 
      similar results. CONCLUSION: Our meta-analysis identified that plasma Hcy levels 
      were significantly elevated in HF patients compared to control subjects, which is 
      positively related to the advancement of NYHA class.
CI  - Copyright (c) 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Jin, Nake
AU  - Jin N
AD  - Department of Cardiology, Ningbo Hangzhou Bay Hospital, Ningbo, China.
FAU - Huang, Lei
AU  - Huang L
AUID- ORCID: 0000-0002-6626-459
AD  - Department of Cardiology, Ningbo Hangzhou Bay Hospital, Ningbo, China.
FAU - Hong, Jun
AU  - Hong J
AD  - Department of Cardiology, Ningbo Hangzhou Bay Hospital, Ningbo, China.
FAU - Zhao, Xuechen
AU  - Zhao X
AD  - Department of Cardiology, Ningbo Hangzhou Bay Hospital, Ningbo, China.
FAU - Chen, Yujiao
AU  - Chen Y
AD  - Department of Cardiology, Ningbo Hangzhou Bay Hospital, Ningbo, China.
FAU - Hu, Jianan
AU  - Hu J
AD  - Department of Cardiology, Ningbo Hangzhou Bay Hospital, Ningbo, China.
FAU - Cong, Xin
AU  - Cong X
AD  - Department of Cardiology, Ningbo Hangzhou Bay Hospital, Ningbo, China.
FAU - Xie, Yuquan
AU  - Xie Y
AD  - Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Pu, Jun
AU  - Pu J
AD  - Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
LA  - eng
GR  - 2019Y26/Ningbo Medical Science and Technology Project/
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Heart Failure/*blood/*complications
MH  - Homocysteine/*blood
MH  - Humans
PMC - PMC8376397
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2021/08/21 06:00
MHDA- 2021/09/03 06:00
PMCR- 2021/08/20
CRDT- 2021/08/20 09:05
PHST- 2021/04/18 00:00 [received]
PHST- 2021/07/22 00:00 [accepted]
PHST- 2021/08/20 09:05 [entrez]
PHST- 2021/08/21 06:00 [pubmed]
PHST- 2021/09/03 06:00 [medline]
PHST- 2021/08/20 00:00 [pmc-release]
AID - 00005792-202108200-00009 [pii]
AID - MD-D-21-02817 [pii]
AID - 10.1097/MD.0000000000026875 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2021 Aug 20;100(33):e26875. doi: 
      10.1097/MD.0000000000026875.