PMID- 34414948
OWN - NLM
STAT- MEDLINE
DCOM- 20210902
LR  - 20230103
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 100
IP  - 33
DP  - 2021 Aug 20
TI  - Long non-coding RNA as a potential biomarker for prognosis of glioma: A protocol 
      for systematic review and meta-analysis.
PG  - e26921
LID - 10.1097/MD.0000000000026921 [doi]
LID - e26921
AB  - BACKGROUND: The molecular mechanism of Glioma is still unclear, and there are few 
      early diagnostic markers. Therefore, it is urgent to figure out effective 
      preventive measures, active diagnostic methods and rapid treatment measures. In 
      recent years, relevant studies have revealed that long non-coding RNA (lncRNA) is 
      associated with the prognosis of Glioma. However, these results have not been 
      supported by any evidence. Therefore, this study carried out a meta-analysis 
      method to analyze the relationship between lncRNA and the prognosis of Glioma. In 
      addition, bioinformatics analysis was conducted to investigate the mechanism and 
      related pathways of lncRNAs in Glioma. METHODS: We performed a systematic search 
      in electronic databases, including China National Knowledge Infrastructure, 
      Chinese Biomedical literature Database, Chinese Scientific and Journal Database, 
      Wan Fang database, PubMed, EMBASE, Cochrane Library and Web of Science, to 
      investigate the potential association between lncRNA expression and prognostic 
      significance and clinical features in glioma patients. Hazards ratios (HRs) with 
      corresponding 95% confidence intervals (CIs) were pooled to estimate the 
      prognosis value of lncRNA by Stata16.0 software. The online tool AnnoLnc was 
      applied to screen the co-expressed gene related to each lncRNA, David was used 
      for gene ontology (GO) analysis and enrichment analysis of the signal pathway, 
      and through Starbase, the possible competitive endogenous RNA network of lncRNAs 
      was constructed. RESULTS: The results of this meta-analysis would be submitted to 
      peer-reviewed journals for publication. CONCLUSION: This study will provide 
      evidence-based medical evidence for lncRNA, so as to predict the prognosis of 
      Glioma and bioinformatics analysis will provide ideas for the mechanism study on 
      Glioma.
CI  - Copyright (c) 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Xie, Teng
AU  - Xie T
AD  - Department of Neurosurgery, The People's Hospital of Hanchuan, Hanchuan, Hubei 
      province, China.
FAU - Li, Bin
AU  - Li B
AD  - Department of Neurosurgery, The People's Hospital of Hanchuan, Hanchuan, Hubei 
      province, China.
FAU - Liu, Huaming
AU  - Liu H
AD  - Department of Neurosurgery, The People's Hospital of Hanchuan, Hanchuan, Hubei 
      province, China.
FAU - Zhang, Chunwei
AU  - Zhang C
AD  - Department of Neurosurgery, The People's Hospital of Hanchuan, Hanchuan, Hubei 
      province, China.
FAU - Wang, Yanhua
AU  - Wang Y
AD  - Department of Neurosurgery, The People's Hospital of Hanchuan, Hanchuan, Hubei 
      province, China.
FAU - Chen, Zhijun
AU  - Chen Z
AD  - Department of Neurosurgery, The First People's Hospital of Jingmen, Jingmen, 
      Hubei province, China.
FAU - Yan, Junping
AU  - Yan J
AUID- ORCID: 0000-0002-2988-2305
AD  - Department of Neurosurgery, The People's Hospital of Hanchuan, Hanchuan, Hubei 
      province, China.
LA  - eng
GR  - No. WJ2019M076/general project of natural science foundation of health commission 
      of hubei province/
GR  - No.2018CFB784/a grant from the general project of natural science foundation of 
      science and technology department of hubei province/
GR  - No.2019YFZD041/science and technology plan project of jingmen city hubei 
      province/
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Biomarkers, Tumor/*genetics
MH  - Glioma/*genetics
MH  - Humans
MH  - *Meta-Analysis as Topic
MH  - Prognosis
MH  - RNA, Long Noncoding/*genetics
MH  - *Research Design
MH  - Systematic Reviews as Topic/*methods
PMC - PMC8376343
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2021/08/21 06:00
MHDA- 2021/09/03 06:00
PMCR- 2021/08/20
CRDT- 2021/08/20 09:05
PHST- 2021/07/21 00:00 [received]
PHST- 2021/07/27 00:00 [accepted]
PHST- 2021/08/20 09:05 [entrez]
PHST- 2021/08/21 06:00 [pubmed]
PHST- 2021/09/03 06:00 [medline]
PHST- 2021/08/20 00:00 [pmc-release]
AID - 00005792-202108200-00018 [pii]
AID - MD-D-21-05173 [pii]
AID - 10.1097/MD.0000000000026921 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2021 Aug 20;100(33):e26921. doi: 
      10.1097/MD.0000000000026921.