PMID- 34415057
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20230202
IS  - 1096-9861 (Electronic)
IS  - 0021-9967 (Print)
IS  - 0021-9967 (Linking)
VI  - 530
IP  - 3
DP  - 2022 Feb
TI  - A sex-specific feedback projection from aromatase-expressing neurons in the 
      medial amygdala to the accessory olfactory bulb.
PG  - 648-655
LID - 10.1002/cne.25236 [doi]
AB  - The accessory olfactory bulb (AOB) plays a critical role in classifying 
      pheromonal signals. Here we identify two previously undescribed sources of 
      aromatase signaling in the AOB: (1) a population of aromatase-expressing neurons 
      in the AOB itself; (2) a tract of aromatase-expressing axons which originate in 
      the ventral medial amygdala (MEA) and terminate in the AOB. Using a retrograde 
      tracer in conjunction with a transgenic strategy to label aromatase-expressing 
      neurons throughout the brain, we found that a single contiguous population of 
      neurons in the ventral MEA provides the only significant feedback by 
      aromatase-expressing neurons to the AOB. This population expresses the estrogen 
      receptor alpha (ERalpha) and displayed anatomical sex differences in the number of 
      neurons (higher in male mice) and the size of cell bodies (larger in females). 
      Given the previously established relationship between aromatase expression, 
      estrogen signaling, and the function of sexually dimorphic circuits, we suggest 
      that this feedback population is well-positioned to provide neuroendocrine 
      feedback to modulate sensory processing of social stimuli in the AOB.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Inbar, Tal
AU  - Inbar T
AD  - Neuroscience and Behavior Graduate Program, University of Massachusetts Amherst, 
      Amherst, Massachusetts, USA.
FAU - Davis, Rachel
AU  - Davis R
AD  - Department of Psychological and Brain Sciences, University of Massachusetts 
      Amherst, Amherst, Massachusetts, USA.
FAU - Bergan, Joseph F
AU  - Bergan JF
AUID- ORCID: 0000-0002-9386-2595
AD  - Neuroscience and Behavior Graduate Program, University of Massachusetts Amherst, 
      Amherst, Massachusetts, USA.
AD  - Department of Psychological and Brain Sciences, University of Massachusetts 
      Amherst, Amherst, Massachusetts, USA.
LA  - eng
GR  - R01 MH115094/MH/NIMH NIH HHS/United States
GR  - R01MH115094-01A1/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20210827
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
RN  - EC 1.14.14.1 (Aromatase)
SB  - IM
MH  - Amygdala/metabolism
MH  - Animals
MH  - Aromatase/metabolism
MH  - Feedback
MH  - Female
MH  - Male
MH  - Mice
MH  - Neurons/metabolism
MH  - *Olfactory Bulb/metabolism
MH  - *Vomeronasal Organ/metabolism
PMC - PMC8716422
MID - NIHMS1734350
OTO - NOTNLM
OT  - aromatase
OT  - feedback
OT  - medial amygdala
OT  - olfactory
OT  - pheromones
OT  - vomeronasal
COIS- CONFLICT OF INTEREST: The authors declare no conflict of interest.
EDAT- 2021/08/21 06:00
MHDA- 2022/04/05 06:00
PMCR- 2023/02/01
CRDT- 2021/08/20 09:09
PHST- 2021/08/09 00:00 [revised]
PHST- 2021/06/28 00:00 [received]
PHST- 2021/08/17 00:00 [accepted]
PHST- 2021/08/21 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2021/08/20 09:09 [entrez]
PHST- 2023/02/01 00:00 [pmc-release]
AID - 10.1002/cne.25236 [doi]
PST - ppublish
SO  - J Comp Neurol. 2022 Feb;530(3):648-655. doi: 10.1002/cne.25236. Epub 2021 Aug 27.