PMID- 34415720
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230926
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 13
IP  - 44
DP  - 2021 Nov 10
TI  - MCP-1-Functionalized, Core-Shell Gold Nanorod@Iron-Based Metal-Organic Framework 
      (MCP-1/GNR@MIL-100(Fe)) for Photothermal Therapy.
PG  - 52092-52105
LID - 10.1021/acsami.1c09518 [doi]
AB  - The low vessel density and oxygen concentration in hypoxia are the main causes of 
      reduced efficiency of anticancer therapeutics and can stimulate the tumor's 
      relapse. Research showed that macrophages could cross the blood-vessel barriers 
      and reach the hypoxic regions of tumors. Using macrophages in a drug delivery 
      system has been a promising method for tumor targeting in recent years. In this 
      work, we successfully modified monocyte chemoattractant protein-1 (MCP-1) and 
      iron-based metal-organic framework (MIL-100(Fe)) on the photothermal agent, gold 
      nanorods (GNRs) (i.e., MCP-1/GNR@MIL-100(Fe)), to increase cellular uptake and 
      biocompatibility. The results of TEM, UV-vis, and FTIR all confirmed that we'd 
      synthesized MCP-1/GNR@MIL-100(Fe) successfully, and the MCP-1/GNR@MIL-100(Fe) 
      also showed good biocompatibility. A transwell migration assay illustrated that 
      our material attracted macrophages, and the material uptake amount was increased 
      by 1.5 times after MCP-1 functionalization. It also indicated that the 
      macrophages have a tumor-targeting ability. In the in vivo experiment, we 
      subcutaneously implanted U251 MG cells in nude mice as a xenograft model to 
      demonstrate the photothermal activity of MCP-1/GNR@MIL-100(Fe). With successive 
      NIR treatment, the tumor growth could be controlled, and the tumor volume still 
      remained below 100 mm(3) after laser treatment. MCP-1/GNR@MIL-100(Fe) combined 
      with the laser treatment showed an excellent antitumor efficacy from the 
      histology of tumor tissues, survival rates, and bioluminescence imaging.
FAU - Chien, Wei-Cheng
AU  - Chien WC
AD  - Department of Chemical Engineering, National Taiwan University, No. 1, Sec. 4, 
      Roosevelt Road, Taipei 10617, Taiwan.
FAU - Cheng, Po-Hsiu
AU  - Cheng PH
AD  - Department of Chemical Engineering, National Taiwan University, No. 1, Sec. 4, 
      Roosevelt Road, Taipei 10617, Taiwan.
AD  - Division of Neurosurgery, Chang Gung Memorial Hospital, No. 5, Fuxing Street, 
      Guishan District, Taoyuan City 333, Taiwan.
AD  - Department of International Graduate Program of Molecular Science and Technology, 
      National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan.
FAU - Cheng, Xu-Jun
AU  - Cheng XJ
AD  - Department of Chemical Engineering, National Taiwan University, No. 1, Sec. 4, 
      Roosevelt Road, Taipei 10617, Taiwan.
FAU - Chuang, Chi-Cheng
AU  - Chuang CC
AD  - Division of Neurosurgery, Chang Gung Memorial Hospital, No. 5, Fuxing Street, 
      Guishan District, Taoyuan City 333, Taiwan.
FAU - Huang, Yu-Ting
AU  - Huang YT
AD  - Division of Neurosurgery, Chang Gung Memorial Hospital, No. 5, Fuxing Street, 
      Guishan District, Taoyuan City 333, Taiwan.
FAU - T S, Anilkumar
AU  - T S A
AD  - Division of Neurosurgery, Chang Gung Memorial Hospital, No. 5, Fuxing Street, 
      Guishan District, Taoyuan City 333, Taiwan.
FAU - Liu, Chia-Hung
AU  - Liu CH
AD  - Department of Urology, School of Medicine, College of Medicine, Taipei Medical 
      University, No. 250, Wu-Hsing Street, Taipei 110, Taiwan.
AD  - TMU Research Center of Urology and Kidney, Taipei Medical University, No. 250, 
      Wu-Hsing Street, Taipei 110, Taiwan.
AD  - Department of Urology, Shuang Ho Hospital, Taipei Medical University, No. 291, 
      Zhongzheng Road, Zhonghe District, New Taipei City 23561, Taiwan.
FAU - Lu, Yu-Jen
AU  - Lu YJ
AD  - Division of Neurosurgery, Chang Gung Memorial Hospital, No. 5, Fuxing Street, 
      Guishan District, Taoyuan City 333, Taiwan.
AD  - College of Medicine, Chang Gung University, No.259, Wenhua First Road, Guishan 
      District, Taoyuan City 33302, Taiwan.
AD  - Center for Biomedical Science and Engineering, National Tsing Hua University, 
      101, Section 2, Kuang-Fu Road, Hsinchu 300044, Taiwan.
FAU - Wu, Kevin C-W
AU  - Wu KC
AUID- ORCID: 0000-0003-0590-1396
AD  - Department of Chemical Engineering, National Taiwan University, No. 1, Sec. 4, 
      Roosevelt Road, Taipei 10617, Taiwan.
AD  - Department of International Graduate Program of Molecular Science and Technology, 
      National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan.
AD  - Division of Biomedical Engineering & Nanomedicine, National Health Research 
      Institutes, Maoli County 350, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210820
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
SB  - IM
OTO - NOTNLM
OT  - MIL-100(Fe)
OT  - glioblastoma
OT  - gold nanorods
OT  - monocyte chemoattractant protein-1
OT  - photothermal therapy
EDAT- 2021/08/21 06:00
MHDA- 2021/08/21 06:01
CRDT- 2021/08/20 17:10
PHST- 2021/08/21 06:01 [medline]
PHST- 2021/08/21 06:00 [pubmed]
PHST- 2021/08/20 17:10 [entrez]
AID - 10.1021/acsami.1c09518 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2021 Nov 10;13(44):52092-52105. doi: 
      10.1021/acsami.1c09518. Epub 2021 Aug 20.