PMID- 34416379
OWN - NLM
STAT- MEDLINE
DCOM- 20211011
LR  - 20211011
IS  - 1872-9649 (Electronic)
IS  - 1568-1637 (Linking)
VI  - 71
DP  - 2021 Nov
TI  - Effectiveness of caregiver non-pharmacological interventions for behavioural and 
      psychological symptoms of dementia: An updated meta-analysis.
PG  - 101448
LID - S1568-1637(21)00195-1 [pii]
LID - 10.1016/j.arr.2021.101448 [doi]
AB  - BACKGROUND: The behavioural and psychological symptoms of dementia (BPSD) have 
      significant negative effects on the health of both patients with dementia and 
      their caregivers. However, the reported effectiveness of non-pharmacological 
      interventions targeting caregivers of patients with dementia for BPSD is 
      inconsistent. METHODS: We systematically searched the databases PubMed, PsycINFO, 
      CINAHL, Embase, Cochrane Library and four Chinese databases from 2010 through 
      April 2021. The Standardised mean difference (SMD) was calculated using 
      random-effects models. Risk of bias in individual studies was assessed using 
      Cochrane Collaboration's tool, and the certainty of evidence was assessed using 
      the five GRADE criteria. RESULTS: Thirty-one randomised controlled trials (RCTs) 
      involving 3501 dyads were included. The meta-analysis indicated that 
      non-pharmacological interventions showed small but significant effects on both 
      BPSD in patients with dementia (SMD = -0.14; 95% CI, -0.22 to -0.06; P = 0.001) 
      and caregiver reactions to BPSD (SMD = -0.16; 95% CI, -0.25 to -0.07; P = 0.001). 
      The effect sizes of BPSD in patients at follow-up (SMD = -0.24; 95% CI, -0.38 to 
      -0.09; P = 0.002) were larger than those at post-test. Tailored interventions 
      were associated with more substantial reductions in BPSD in patients (SMD = 
      -0.24; 95% CI, -0.37 to -0.11; P < 0.001) than standardised interventions (SMD = 
      -0.07; 95% CI, -0.18 to 0.04; P = 0.218). CONCLUSIONS: Non-pharmacological 
      interventions targeting caregivers have the potential to reduce BPSD in patients 
      with dementia and improve caregiver negative reactions to BPSD. Moreover, 
      tailored interventions seemed to be more effective in reducing BPSD, and more 
      significant improvements in BPSD may be observed in long-term follow-up.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Meng, Xiangfei
AU  - Meng X
AD  - School of Nursing, Jilin University, Changchun, China.
FAU - Su, Jianping
AU  - Su J
AD  - School of Nursing, Jilin University, Changchun, China; School of Nursing, 
      Xinjiang Medical University, Urumqi Municipality, China.
FAU - Li, Huanhuan
AU  - Li H
AD  - School of Nursing, Jilin University, Changchun, China.
FAU - Ma, Dongfei
AU  - Ma D
AD  - School of Nursing, Jilin University, Changchun, China.
FAU - Zhao, Yingnan
AU  - Zhao Y
AD  - School of Nursing, Jilin University, Changchun, China.
FAU - Li, Yijing
AU  - Li Y
AD  - School of Nursing, Jilin University, Changchun, China.
FAU - Zhang, Xu
AU  - Zhang X
AD  - School of Nursing, Jilin University, Changchun, China.
FAU - Li, Zehui
AU  - Li Z
AD  - School of Nursing, Jilin University, Changchun, China.
FAU - Sun, Jiao
AU  - Sun J
AD  - School of Nursing, Jilin University, Changchun, China. Electronic address: 
      sunjiao@jlu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20210817
PL  - England
TA  - Ageing Res Rev
JT  - Ageing research reviews
JID - 101128963
SB  - IM
MH  - *Caregivers
MH  - *Dementia/therapy
MH  - Humans
OTO - NOTNLM
OT  - Behavioural and psychological symptoms of dementia
OT  - Family caregivers
OT  - Meta-analysis
OT  - Non-pharmacological intervention
EDAT- 2021/08/21 06:00
MHDA- 2021/10/12 06:00
CRDT- 2021/08/20 20:15
PHST- 2020/10/27 00:00 [received]
PHST- 2021/07/17 00:00 [revised]
PHST- 2021/08/11 00:00 [accepted]
PHST- 2021/08/21 06:00 [pubmed]
PHST- 2021/10/12 06:00 [medline]
PHST- 2021/08/20 20:15 [entrez]
AID - S1568-1637(21)00195-1 [pii]
AID - 10.1016/j.arr.2021.101448 [doi]
PST - ppublish
SO  - Ageing Res Rev. 2021 Nov;71:101448. doi: 10.1016/j.arr.2021.101448. Epub 2021 Aug 
      17.