PMID- 34416401
OWN - NLM
STAT- MEDLINE
DCOM- 20220124
LR  - 20220124
IS  - 1532-2971 (Electronic)
IS  - 1090-0233 (Linking)
VI  - 276
DP  - 2021 Oct
TI  - Association between ACTH stimulation test results and clinical signs in dogs with 
      hyperadrenocorticism treated with trilostane.
PG  - 105740
LID - S1090-0233(21)00135-0 [pii]
LID - 10.1016/j.tvjl.2021.105740 [doi]
AB  - Trilostane is the recommended medical treatment for dogs with 
      hyperadrenocorticicm (HAC). The objective of this study was to investigate the 
      association between ACTH stimulation test (ACTHST) results, and relevant clinical 
      signs, in dogs treated with trilostane. A disease-specific questionnaire was 
      developed, which included the owner's assessment of polydipsia, polyuria, 
      polyphagia, panting, and satisfaction with the treatment, based on a 5-response 
      category rating scale. Forty-nine dogs with HAC were prospectively enrolled. Dogs 
      were grouped according to their recheck appointment (first recheck, 710 days 
      after commencement of treatment or change of trilostane dose; second recheck, 4 
      weeks after the first recheck; third recheck, performed at 3-6 months intervals 
      once the dog was well controlled). At the recheck appointment, the owner's 
      questionnaire responses were recorded, and an ACTHST was performed, along with 
      urine specific gravity measurement. Linear mixed effects models were used to 
      assess differences among the three recheck time points and to test possible 
      associations between ACTHST results and clinical signs. Significant differences 
      between rechecks were present for stimulated cortisol (first to third recheck, P 
      < 0.001; second to third recheck, P < 0.01), polydipsia (first to second recheck, 
      P = 0.001), polyuria (first to second recheck, P < 0.001; first to third recheck, 
      P = 0.001), and owner satisfaction (first to second recheck, P < 0.001; first to 
      third recheck, P < 0.001). Backward stepwise variable elimination did not 
      identify any significant associations between ACTHST results and clinical signs. 
      Therefore, clinical signs of HAC were not predicted based on the ACTHST results.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Wehner, A
AU  - Wehner A
AD  - Center of Clinical Veterinary Medicine, Clinic of Small Animal Medicine, Ludwig 
      Maximilian University, Munich, Germany. Electronic address: 
      a.wehner@medizinische-kleintierklinik.de.
FAU - Glockner, S
AU  - Glockner S
AD  - Center of Clinical Veterinary Medicine, Clinic of Small Animal Medicine, Ludwig 
      Maximilian University, Munich, Germany.
FAU - Weiss, B
AU  - Weiss B
AD  - Center of Clinical Veterinary Medicine, Clinic of Small Animal Medicine, Ludwig 
      Maximilian University, Munich, Germany.
FAU - Ballhausen, D
AU  - Ballhausen D
AD  - Veterinay Clinic for Small Animals, Haar, Germany.
FAU - Stockhaus, C
AU  - Stockhaus C
AD  - Veterinay Clinic for Small Animals, Haar, Germany.
FAU - Zablotski, Y
AU  - Zablotski Y
AD  - Center of Clinical Veterinary Medicine, Clinic of Small Animal Medicine, Ludwig 
      Maximilian University, Munich, Germany.
FAU - Hartmann, K
AU  - Hartmann K
AD  - Center of Clinical Veterinary Medicine, Clinic of Small Animal Medicine, Ludwig 
      Maximilian University, Munich, Germany.
LA  - eng
PT  - Journal Article
DEP - 20210817
PL  - England
TA  - Vet J
JT  - Veterinary journal (London, England : 1997)
JID - 9706281
RN  - 08J2K08A3Y (Dihydrotestosterone)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - L0FPV48Q5R (trilostane)
SB  - IM
MH  - *Adrenocortical Hyperfunction/diagnosis/drug therapy/veterinary
MH  - Adrenocorticotropic Hormone
MH  - Animals
MH  - Dihydrotestosterone/analogs & derivatives
MH  - *Dog Diseases/diagnosis/drug therapy
MH  - Dogs
OTO - NOTNLM
OT  - Canine
OT  - Cushing syndrome
OT  - Monitoring
OT  - Trilostane
EDAT- 2021/08/21 06:00
MHDA- 2022/01/27 06:00
CRDT- 2021/08/20 20:15
PHST- 2020/10/12 00:00 [received]
PHST- 2021/08/13 00:00 [revised]
PHST- 2021/08/13 00:00 [accepted]
PHST- 2021/08/21 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2021/08/20 20:15 [entrez]
AID - S1090-0233(21)00135-0 [pii]
AID - 10.1016/j.tvjl.2021.105740 [doi]
PST - ppublish
SO  - Vet J. 2021 Oct;276:105740. doi: 10.1016/j.tvjl.2021.105740. Epub 2021 Aug 17.