PMID- 34417277
OWN - NLM
STAT- MEDLINE
DCOM- 20211020
LR  - 20211020
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 44
IP  - 9
DP  - 2021 Sep
TI  - Dietary Intake of Linoleic Acid, Its Concentrations, and the Risk of Type 2 
      Diabetes: A Systematic Review and Dose-Response Meta-analysis of Prospective 
      Cohort Studies.
PG  - 2173-2181
LID - 10.2337/dc21-0438 [doi]
AB  - BACKGROUND: Earlier evidence on the association between dietary polyunsaturated 
      fatty acids and risk of diabetes has been conflicting. PURPOSE: To quantitatively 
      summarize previous studies on the association between dietary LA intake, its 
      biomarkers, and the risk of type 2 diabetes mellitus (T2DM) in the general 
      population. DATA SOURCES: Our data sources included PubMed/MEDLINE, Scopus, and 
      ISI Web of Science until 24 October 2020; reference lists of all related 
      articles; and key journals. STUDY SELECTION: We included prospective cohort 
      studies that examined the associations of linoleic acid (LA) with the risk of 
      T2DM in adults. DATA SYNTHESIS: The inverse variance method was applied to 
      calculate summary relative risk (RR) of LA intake and its biomarkers, and 
      dose-response associations were modeled using restricted cubic splines. 
      Twenty-three publications, covering a total of 31 prospective cohorts, were 
      included; these studies included 297,685 participants (22,639 incident diabetes 
      cases) with dietary intake assessment and 84,171 participants (18,458 incident 
      diabetes cases) with biomarker measurements. High intake of LA was associated 
      with a 6% lower risk of T2DM (summary relative risk [RR] 0.94, 95% CI 0.90, 0.99; 
      I (2) = 48.5%). In the dose-response analysis, each 5% increment in energy from 
      LA intake was associated with a 10% lower risk of T2DM. There was also evidence 
      of a linear association between LA intake and diabetes, with the lowest risk at 
      highest intakes. The summary RR for diabetes per SD increment in LA 
      concentrations in adipose tissue/blood compartments was 0.85 (95% CI 0.80, 0.90; 
      I(2) = 66.2%). The certainty of the evidence was assessed as moderate. 
      LIMITATIONS: A limitation of our work was the observational design of studies 
      included in the analyses. CONCLUSIONS: We found that a high intake of dietary LA 
      and elevated concentrations of LA in the body were both significantly associated 
      with a lower risk of T2DM. These findings support dietary recommendations to 
      consume dietary LA.
CI  - (c) 2021 by the American Diabetes Association.
FAU - Mousavi, Seyed Mohammad
AU  - Mousavi SM
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Jalilpiran, Yahya
AU  - Jalilpiran Y
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Karimi, Elmira
AU  - Karimi E
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Aune, Dagfinn
AU  - Aune D
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Imperial 
      College London, London, U.K.
AD  - Department of Nutrition, Bjorknes University College, Oslo, Norway.
AD  - Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo 
      University Hospital, Oslo, Norway.
AD  - Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental 
      Medicine, Karolinska Institutet, Stockholm, Sweden.
FAU - Larijani, Bagher
AU  - Larijani B
AD  - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism 
      Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Mozaffarian, Dariush
AU  - Mozaffarian D
AD  - Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA.
FAU - Willett, Walter C
AU  - Willett WC
AD  - Departments of Nutrition and Epidemiology, Harvard T.H. Chan School of Public 
      Health, Boston, MA.
AD  - Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard 
      Medical School, Boston, MA.
FAU - Esmaillzadeh, Ahmad
AU  - Esmaillzadeh A
AUID- ORCID: 0000-0002-8735-6047
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran a-esmaillzadeh@tums.ac.ir.
AD  - Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular 
      Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
AD  - Food Security Research Center, Department of Community Nutrition, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
LA  - eng
SI  - figshare/10.2337/figshare.14681142
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20210820
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 9KJL21T0QJ (Linoleic Acid)
SB  - IM
CIN - Diabetes Care. 2021 Sep;44(9):1913-1915. PMID: 34417278
MH  - Adult
MH  - *Diabetes Mellitus, Type 2/epidemiology/etiology
MH  - Diet
MH  - Eating
MH  - Humans
MH  - *Linoleic Acid
MH  - Prospective Studies
MH  - Risk Factors
EDAT- 2021/08/22 06:00
MHDA- 2021/10/21 06:00
CRDT- 2021/08/21 05:35
PHST- 2021/02/26 00:00 [received]
PHST- 2021/05/21 00:00 [accepted]
PHST- 2021/08/22 06:00 [pubmed]
PHST- 2021/10/21 06:00 [medline]
PHST- 2021/08/21 05:35 [entrez]
AID - dc21-0438 [pii]
AID - 10.2337/dc21-0438 [doi]
PST - ppublish
SO  - Diabetes Care. 2021 Sep;44(9):2173-2181. doi: 10.2337/dc21-0438. Epub 2021 Aug 
      20.