PMID- 34419454
OWN - NLM
STAT- MEDLINE
DCOM- 20220107
LR  - 20240226
IS  - 1096-0309 (Electronic)
IS  - 0003-2697 (Linking)
VI  - 631
DP  - 2021 Oct 15
TI  - Protection function of 18beta-glycyrrhetinic acid on rats with high-altitude 
      pulmonary hypertension based on (1)H NMR metabonomics technology.
PG  - 114342
LID - S0003-2697(21)00243-8 [pii]
LID - 10.1016/j.ab.2021.114342 [doi]
AB  - 18beta-Glycyrrhetinic acid (GA) is the triterpenoid aglycone component of 
      glycyrrhizic acid, a natural product of traditional Chinese medicine, and has 
      been proven to possess a variety of pharmacological effects. The protection 
      function and the mechanism of GA on rats with high-altitude pulmonary 
      hypertension (HAPH) are studied using proton nuclear magnetic resonance ((1)H 
      NMR) metabonomics technology and biochemical analysis. An HAPH model is 
      established, and 60 male rats are randomly divided into the following groups: 
      Control(normal saline, 0.4 mL/100 g), model (normal saline, 0.4 mL/100 g), 
      Nifedipine (nifedipine, 2.7 mg/kg), and high-, medium-, and low-dose GA groups 
      (100, 50, and 25 mg/kg GA designated as GA.H, GA.M, and GA.L, respectively). 
      Serum biochemical indicators of rats in each group are measured, and pathological 
      changes in the pulmonary artery are observed. (1)H NMR metabonomics technology is 
      used for serum analysis. Results show that GA can significantly reduce pulmonary 
      arterial pressure and malondialdehyde levels and increase the glutathione 
      peroxidase and superoxide dismutase activities in HAPH rats. Pathological results 
      show that GA can alleviate pulmonary artery injuries of HAPH rats. Metabolomics 
      analytical findings show that GA can alleviate the metabolic disorder of HAPH 
      rats through anti-oxidation and anti-inflammatory effects, improve their bodies' 
      ability to resist hypoxia, and restore various metabolic pathways (energy 
      metabolism, amino acid metabolism, and lipid metabolism). GA has potential 
      therapeutic effects on HAPH rats, but its target needs to be further studied.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Yang, Tao
AU  - Yang T
AD  - Central Laboratory, Xinjiang Medical University, Urumqi, 830011, China.
FAU - Zhou, Jing
AU  - Zhou J
AD  - Department of Human Resources, General Hospital of Xinjiang Military, Urumqi, 
      830011, China.
FAU - Fang, Lei
AU  - Fang L
AD  - College of Pharmacy, Xinjiang Medical University, Urumqi, 830011, China.
FAU - Wang, Minmin
AU  - Wang M
AD  - College of Pharmacy, Xinjiang Medical University, Urumqi, 830011, China.
FAU - Dilinuer, Maimaitiyiming
AU  - Dilinuer M
AD  - Heart Center, The First Affiliated Hospital of Xinjiang Medical University, 
      Urumqi, 830054, China.
FAU - Ainiwaer, Aikemu
AU  - Ainiwaer A
AD  - College of Pharmacy, Xinjiang Medical University, Urumqi, 830011, China; Key 
      Laboratory of Active Components of Xinjiang Natural Medicine and Drug Release 
      Technology, Xinjiang Medical University, Urumqi, 830011, China. Electronic 
      address: ainiwa@sina.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210819
PL  - United States
TA  - Anal Biochem
JT  - Analytical biochemistry
JID - 0370535
RN  - 0 (Protective Agents)
RN  - 0 (Protons)
RN  - 1449-05-4 (18alpha-glycyrrhetinic acid)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - P540XA09DR (Glycyrrhetinic Acid)
RN  - Pulmonary edema of mountaineers
SB  - IM
MH  - Altitude Sickness/etiology/pathology/*prevention & control
MH  - Animals
MH  - Blood Chemical Analysis/methods
MH  - Disease Models, Animal
MH  - Energy Metabolism/drug effects
MH  - Glycyrrhetinic Acid/administration & dosage/*analogs & derivatives/pharmacology
MH  - Hypertension, Pulmonary/etiology/pathology/*prevention & control
MH  - Lipid Metabolism/drug effects
MH  - Magnetic Resonance Spectroscopy/*methods
MH  - Male
MH  - Malondialdehyde/blood
MH  - Metabolomics/*methods
MH  - Multivariate Analysis
MH  - Protective Agents/administration & dosage/*pharmacology
MH  - Protons
MH  - Pulmonary Artery/drug effects/ultrastructure
MH  - Rats, Sprague-Dawley
MH  - Superoxide Dismutase/blood
MH  - Rats
OTO - NOTNLM
OT  - Glycyrrhetinic acid
OT  - High-altitude pulmonary hypertension
OT  - Metabonomics
OT  - Nuclear magnetic resonance
EDAT- 2021/08/23 06:00
MHDA- 2022/01/08 06:00
CRDT- 2021/08/22 20:42
PHST- 2021/04/14 00:00 [received]
PHST- 2021/08/02 00:00 [revised]
PHST- 2021/08/16 00:00 [accepted]
PHST- 2021/08/23 06:00 [pubmed]
PHST- 2022/01/08 06:00 [medline]
PHST- 2021/08/22 20:42 [entrez]
AID - S0003-2697(21)00243-8 [pii]
AID - 10.1016/j.ab.2021.114342 [doi]
PST - ppublish
SO  - Anal Biochem. 2021 Oct 15;631:114342. doi: 10.1016/j.ab.2021.114342. Epub 2021 
      Aug 19.