PMID- 34419464 OWN - NLM STAT- MEDLINE DCOM- 20220106 LR - 20240319 IS - 1096-0953 (Electronic) IS - 0013-9351 (Print) IS - 0013-9351 (Linking) VI - 204 IP - Pt A DP - 2022 Mar TI - Early-life exposure to perfluoroalkyl substances in relation to serum adipokines in a longitudinal birth cohort. PG - 111905 LID - S0013-9351(21)01200-7 [pii] LID - 10.1016/j.envres.2021.111905 [doi] AB - BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) exposure has been linked to metabolic health outcomes such as obesity, and changes in adipokine hormones may be one of the underlying biological mechanisms. We prospectively evaluated the associations between prenatal and early childhood exposures to PFASs and adipokines in children. MATERIAL AND METHODS: PFAS concentrations were measured in serum samples collected at birth, 18 months, and 5 and 9 years, and adiponectin, leptin, leptin receptor, and resistin were measured in serum samples collected at birth and 9 years. We used multivariable linear regression models to estimate the percent change in serum-adipokine concentrations for a doubling in serum-PFAS concentrations. The potential sex-specific effect of PFAS was assessed by including an interaction term between PFAS and sex in each model. Bayesian kernel machine regression (BKMR) was implemented to evaluate the overall effect of PFAS mixtures. RESULTS: Significant associations with leptin, leptin receptor, and resistin at age 9 years were observed for serum-PFAS concentrations at 18 months and 5 and 9 years, whereas associations for PFAS concentrations at birth were mostly null. However, we observed a positive association between serum-PFHxS at birth and leptin receptor at birth. We found limited evidence regarding modification effect of sex on serum-PFAS concentrations. BKMR findings were consistent and suggested some significant effects of the overall PFAS mixtures at 18 months and 5 and 9 years on adipokine concentrations at 9 years. CONCLUSIONS: Given the associations of PFAS exposure with both adipokine hormones and metabolic functions, future studies should include assessment of adipokine hormones when examining PFAS-associated metabolic alterations. CI - Copyright (c) 2021 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Shih, Yu-Hsuan AU - Shih YH AD - Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA. FAU - Blomberg, Annelise J AU - Blomberg AJ AD - Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA; Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden. FAU - Jorgensen, Louise Helskov AU - Jorgensen LH AD - Department of Clinical Biochemistry and Pharmacology, Odense University Hospital and Institute of Clinical Research, University of Southern Denmark, Odense, Denmark. FAU - Weihe, Pal AU - Weihe P AD - Department of Occupational Medicine and Public Health, Faroese Hospital System, Torshavn, Faroe Islands; Center of Health Science, University of the Faroe Islands, Torshavn, Faroe Islands. FAU - Grandjean, Philippe AU - Grandjean P AD - Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA; Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark. Electronic address: pgrand@hsph.harvard.edu. LA - eng GR - P30 ES000002/ES/NIEHS NIH HHS/United States GR - P42 ES027706/ES/NIEHS NIH HHS/United States GR - R01 ES026596/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20210819 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 0 (Adipokines) RN - 0 (Alkanesulfonic Acids) RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) SB - IM MH - Adipokines MH - *Alkanesulfonic Acids MH - Bayes Theorem MH - Birth Cohort MH - Child MH - Child, Preschool MH - *Environmental Pollutants MH - Female MH - *Fluorocarbons/toxicity MH - Humans MH - Infant, Newborn MH - Male MH - Pregnancy PMC - PMC10926841 MID - NIHMS1960377 OTO - NOTNLM OT - Adipokine OT - Childhood OT - Metabolic health OT - Perfluoroalkyl substances OT - Prospective study COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: PG has provided paid expert assistance in legal cases involving PFAS-exposed populations. Otherwise, the authors have no actual or potential competing financial interests. EDAT- 2021/08/23 06:00 MHDA- 2022/01/07 06:00 PMCR- 2024/03/11 CRDT- 2021/08/22 20:42 PHST- 2021/06/01 00:00 [received] PHST- 2021/08/11 00:00 [revised] PHST- 2021/08/16 00:00 [accepted] PHST- 2021/08/23 06:00 [pubmed] PHST- 2022/01/07 06:00 [medline] PHST- 2021/08/22 20:42 [entrez] PHST- 2024/03/11 00:00 [pmc-release] AID - S0013-9351(21)01200-7 [pii] AID - 10.1016/j.envres.2021.111905 [doi] PST - ppublish SO - Environ Res. 2022 Mar;204(Pt A):111905. doi: 10.1016/j.envres.2021.111905. Epub 2021 Aug 19.