PMID- 34419762
OWN - NLM
STAT- MEDLINE
DCOM- 20220314
LR  - 20220314
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Linking)
VI  - 133
DP  - 2021 Nov
TI  - Glutamate levels in the medial prefrontal cortex of healthy pregnant women 
      compared to non-pregnant controls.
PG  - 105382
LID - S0306-4530(21)00256-0 [pii]
LID - 10.1016/j.psyneuen.2021.105382 [doi]
AB  - Very little is known about maternal cerebral changes during pregnancy. Since 
      there is an increased risk for major depression during pregnancy and postpartum, 
      it is important to understand the structural and neurochemical changes that occur 
      in the brain during pregnancy. Using proton magnetic resonance spectroscopy 
      ((1)H-MRS) (3 T field strength), glutamate (Glu) levels were measured in the 
      medial prefrontal cortex (MPFC) of 21 healthy gravid subjects 2-3 weeks before 
      their due date (6.74 +/- 1.39), and in 14 non-pregnant healthy controls during 
      their follicular phase (8.53 +/- 1.55). Water quantified MPFC Glu levels were 
      decreased in pregnant women (p < 0.01). We also observed a 13.9% decrease in 
      percentage grey matter (%GM) (p < 0.01) in our MPFC voxel. As Glu is mostly found 
      in GM, we repeated the statistical analysis after adjustment for %GM and found 
      that the difference in Glu levels was no longer statistically significant when 
      adjusted for %GM (p = 0.10). This investigation is the only systematic direct 
      investigation of brain tissue composition and Glu levels in pregnant women. The 
      main finding of this investigation is the decreased %GM in healthy pregnant women 
      compared to non-pregnant women. These findings of decreased %GM in pregnancy may 
      be responsible for the frequent complaints by pregnant women of cognitive 
      difficulties also described as pregnesia.
CI  - Crown Copyright (c) 2021. Published by Elsevier Ltd. All rights reserved.
FAU - McEwen, A M
AU  - McEwen AM
AD  - Department of Psychiatry, University of Alberta, Room 1E7.14, 8440 112 Street 
      Walter Mackenzie Center, Edmonton T6G 2B7, Alberta, Canada.
FAU - Burgess, D T A
AU  - Burgess DTA
AD  - Department of Psychiatry, University of Alberta, Room 1E7.14, 8440 112 Street 
      Walter Mackenzie Center, Edmonton T6G 2B7, Alberta, Canada.
FAU - Hanstock, S E C
AU  - Hanstock SEC
AD  - Department of Psychiatry, University of Alberta, Room 1E7.14, 8440 112 Street 
      Walter Mackenzie Center, Edmonton T6G 2B7, Alberta, Canada.
FAU - Hanstock, C C
AU  - Hanstock CC
AD  - Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, 
      Canada.
FAU - Seres, P
AU  - Seres P
AD  - Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, 
      Canada.
FAU - Khalili, P
AU  - Khalili P
AD  - Department of Psychiatry, University of Alberta, Room 1E7.14, 8440 112 Street 
      Walter Mackenzie Center, Edmonton T6G 2B7, Alberta, Canada.
FAU - Newman, S C
AU  - Newman SC
AD  - Department of Psychiatry, University of Alberta, Room 1E7.14, 8440 112 Street 
      Walter Mackenzie Center, Edmonton T6G 2B7, Alberta, Canada.
FAU - Baker, G B
AU  - Baker GB
AD  - Department of Psychiatry, University of Alberta, Room 1E7.14, 8440 112 Street 
      Walter Mackenzie Center, Edmonton T6G 2B7, Alberta, Canada.
FAU - Mitchell, N D
AU  - Mitchell ND
AD  - Department of Psychiatry, University of Alberta, Room 1E7.14, 8440 112 Street 
      Walter Mackenzie Center, Edmonton T6G 2B7, Alberta, Canada.
FAU - Allen, P S
AU  - Allen PS
AD  - Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, 
      Canada.
FAU - Le Melledo, J-M
AU  - Le Melledo JM
AD  - Department of Psychiatry, University of Alberta, Room 1E7.14, 8440 112 Street 
      Walter Mackenzie Center, Edmonton T6G 2B7, Alberta, Canada. Electronic address: 
      jean-michel.lemelledo@ualberta.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210808
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Case-Control Studies
MH  - Female
MH  - *Glutamic Acid/metabolism
MH  - Humans
MH  - *Prefrontal Cortex/metabolism
MH  - Pregnancy
MH  - Pregnant Women
MH  - Proton Magnetic Resonance Spectroscopy
OTO - NOTNLM
OT  - Depression
OT  - Glutamate
OT  - Grey matter
OT  - Magnetic resonance spectroscopy
OT  - Prefrontal cortex
OT  - Pregnancy
OT  - Pregnesia
EDAT- 2021/08/23 06:00
MHDA- 2022/03/15 06:00
CRDT- 2021/08/22 20:53
PHST- 2020/11/22 00:00 [received]
PHST- 2021/04/20 00:00 [revised]
PHST- 2021/08/04 00:00 [accepted]
PHST- 2021/08/23 06:00 [pubmed]
PHST- 2022/03/15 06:00 [medline]
PHST- 2021/08/22 20:53 [entrez]
AID - S0306-4530(21)00256-0 [pii]
AID - 10.1016/j.psyneuen.2021.105382 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2021 Nov;133:105382. doi: 
      10.1016/j.psyneuen.2021.105382. Epub 2021 Aug 8.