PMID- 34420577
OWN - NLM
STAT- MEDLINE
DCOM- 20220311
LR  - 20220722
IS  - 0083-6729 (Print)
IS  - 0083-6729 (Linking)
VI  - 117
DP  - 2021
TI  - Regulation of neurotropic herpesvirus productive infection and 
      latency-reactivation cycle by glucocorticoid receptor and stress-induced 
      transcription factors.
PG  - 101-132
LID - S0083-6729(21)00049-2 [pii]
LID - 10.1016/bs.vh.2021.06.005 [doi]
AB  - Neurotropic alpha-herpesvirinae subfamily members, herpes simplex virus type 1 
      (HSV-1) and bovine herpesvirus 1 (BoHV-1), are important viral pathogens in their 
      respective hosts. Following acute infection on mucosal surfaces, these viruses 
      establish life-long latency in neurons within trigeminal ganglia (TG) and central 
      nervous system. Chronic or acute stress (physiological or psychological) 
      increases the frequency of reactivation from latency, which leads to virus 
      shedding, virus transmission, and recurrent disease. While stress impairs immune 
      responses and inflammatory signaling cascades, we predict stressful stimuli 
      directly stimulate viral gene expression and productive infection during early 
      stages of reactivation from latency. For example, BoHV-1 and HSV-1 productive 
      infection is impaired by glucocorticoid receptor (GR) antagonists but is 
      stimulated by the synthetic corticosteroid dexamethasone. Promoters that drive 
      expression of key viral transcriptional regulatory proteins are cooperatively 
      stimulated by GR and specific Kruppel like transcription factors (KLF) induced 
      during stress induced reactivation from latency. The BoHV-1 immediate early 
      transcription unit 1 promoter and contains two GR response elements (GRE) that 
      are essential for cooperative transactivation by GR and KLF15. Conversely, the 
      HSV-1 infected cell protein 0 (ICP0) and ICP4 promoter as well as the BoHV-1 ICP0 
      early promoter lack consensus GREs: however, these promoters are cooperatively 
      transactivated by GR and KLF4 or KLF15. Hence, growing evidence suggests GR and 
      stress-induced transcription factors directly stimulate viral gene expression and 
      productive infection during early stages of reactivation from latency. We predict 
      the immune inhibitory effects of stress enhance virus spread at late stages 
      during reactivation from latency.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Ostler, Jeffery B
AU  - Ostler JB
AD  - Department of Veterinary Pathobiology, Oklahoma State University, College of 
      Veterinary Medicine, Stillwater, OK, United States.
FAU - Sawant, Laximan
AU  - Sawant L
AD  - Department of Veterinary Pathobiology, Oklahoma State University, College of 
      Veterinary Medicine, Stillwater, OK, United States.
FAU - Harrison, Kelly
AU  - Harrison K
AD  - Department of Veterinary Pathobiology, Oklahoma State University, College of 
      Veterinary Medicine, Stillwater, OK, United States.
FAU - Jones, Clinton
AU  - Jones C
AD  - Department of Veterinary Pathobiology, Oklahoma State University, College of 
      Veterinary Medicine, Stillwater, OK, United States. Electronic address: 
      clint.jones10@okstate.edu.
LA  - eng
GR  - P20 GM103648/GM/NIGMS NIH HHS/United States
GR  - R01 NS111167/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20210721
PL  - United States
TA  - Vitam Horm
JT  - Vitamins and hormones
JID - 0413601
RN  - 0 (Receptors, Glucocorticoid)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Gene Expression Regulation, Viral
MH  - *Herpesviridae Infections/genetics/metabolism
MH  - Humans
MH  - *Receptors, Glucocorticoid/genetics/metabolism
MH  - Transcription Factors/genetics
MH  - Virus Activation/genetics
PMC - PMC8609911
MID - NIHMS1755864
OTO - NOTNLM
OT  - Bovine herpesvirus 1 (BoHV-1)
OT  - Glucocorticoid receptor
OT  - Herpes simplex virus type 1 (HSV-1)
OT  - Kruppel like transcription factors
OT  - Neuronal latency
OT  - Reactivation from latency
OT  - Stress
OT  - Stress induced transcription
OT  - alpha-herpesvirinae subfamily members
EDAT- 2021/08/24 06:00
MHDA- 2022/03/12 06:00
PMCR- 2022/07/21
CRDT- 2021/08/23 05:33
PHST- 2021/08/23 05:33 [entrez]
PHST- 2021/08/24 06:00 [pubmed]
PHST- 2022/03/12 06:00 [medline]
PHST- 2022/07/21 00:00 [pmc-release]
AID - S0083-6729(21)00049-2 [pii]
AID - 10.1016/bs.vh.2021.06.005 [doi]
PST - ppublish
SO  - Vitam Horm. 2021;117:101-132. doi: 10.1016/bs.vh.2021.06.005. Epub 2021 Jul 21.