PMID- 34422163
OWN - NLM
STAT- MEDLINE
DCOM- 20210830
LR  - 20210830
IS  - 1937-8688 (Electronic)
VI  - 39
DP  - 2021
TI  - [Relevant immunologic markers in COVID-19].
PG  - 40
LID - 10.11604/pamj.2021.39.40.23481 [doi]
LID - 40
AB  - In its severe form, corona virus disease-19 (COVID-19) is characterized by 
      various immunological abnormalities, dominated by massive pro-inflammatory 
      cytokine and chemokine release, such as IL-6, TNF-alpha, IL-1b, IFN-y and monocyte 
      chemoattractant protein-1 (MCP-1), associated with T CD3, T CD4 and T CD8 
      lymphopenia. These two abnormalities are significantly associated with COVID-19 
      acute severe respiratory syndrome. Conversely, these markers decrease during the 
      favorable course of the disease. Coupled with other biological parameters such as 
      leukopenia, increased level of CRP (C Reactive Protein), ferritin and D-dimers, 
      high levels of IL-6 with CD4 and CD8 T cell lymphopenia may be considered as 
      criteria of disease severity, justifying a rapid admission to the intensive care 
      unit, and are also useful for patient monitoring.
CI  - Copyright: Brahim Admou et al.
FAU - Admou, Brahim
AU  - Admou B
AD  - Laboratoire d'Immunologie, Centre de Recherche Clinique, Centre Hospitalier 
      Universitaire Mohamed-VI, Marrakech, Maroc.
AD  - Laboratoire de Recherche Biosciences, Faculte de Medecine, Universite Cadi Ayyad, 
      Marrakech, Maroc.
LA  - fre
PT  - Journal Article
TT  - COVID-19 et marqueurs immunologiques pertinents.
DEP - 20210517
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
RN  - 0 (Biomarkers)
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
SB  - IM
MH  - Biomarkers/metabolism
MH  - COVID-19/*immunology/physiopathology
MH  - Chemokines/*immunology
MH  - Cytokines/*immunology
MH  - Humans
MH  - Severity of Illness Index
PMC - PMC8356923
OTO - NOTNLM
OT  - COVID-19
OT  - immunological markers
OT  - severe cases
COIS- Les auteurs ne declarent aucun conflit d interets.
EDAT- 2021/08/24 06:00
MHDA- 2021/08/31 06:00
PMCR- 2021/05/17
CRDT- 2021/08/23 06:30
PHST- 2020/05/13 00:00 [received]
PHST- 2021/05/10 00:00 [accepted]
PHST- 2021/08/23 06:30 [entrez]
PHST- 2021/08/24 06:00 [pubmed]
PHST- 2021/08/31 06:00 [medline]
PHST- 2021/05/17 00:00 [pmc-release]
AID - PAMJ-39-40 [pii]
AID - 10.11604/pamj.2021.39.40.23481 [doi]
PST - epublish
SO  - Pan Afr Med J. 2021 May 17;39:40. doi: 10.11604/pamj.2021.39.40.23481. 
      eCollection 2021.