PMID- 34422892
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231107
IS  - 2296-875X (Print)
IS  - 2296-875X (Electronic)
IS  - 2296-875X (Linking)
VI  - 8
DP  - 2021
TI  - Hyaluronic Acid Is an Effective Dermal Filler for Lip Augmentation: A 
      Meta-Analysis.
PG  - 681028
LID - 10.3389/fsurg.2021.681028 [doi]
LID - 681028
AB  - Introduction: The lips and the mouth play an indispensable role in vocalization, 
      mastication and face aesthetics. Various noxious factors may alter and destruct 
      the original structure, and appearance of the lips and the anatomical area 
      surrounding the mouth. The application of hyaluronic acid (HA) may serve as a 
      safe method for lip regeneration. Although a number of studies exist for HA 
      effectiveness and safety, its beneficial effect is not well-established. Aim: The 
      present meta-analysis and systematic review was performed to investigate the 
      effectiveness of HA on lip augmentation. We also investigated the types and 
      nature of adverse effects (AEs) of HA application. Methods: We reported our 
      meta-analysis in accordance with the PRISMA Statement. PROSPERO protocol 
      registration: CRD42018102899. We performed the systematic literature search in 
      CENTRAL, Embase, and MEDLINE. Randomized controlled trials, cohort studies, case 
      series and case reports were included. The untransformed proportion 
      (random-effects, DerSimonian-Laird method) of responder rate to HA injection was 
      calculated. For treatment related AEs descriptive statistics were used. Results: 
      The systematic literature search yielded 32 eligible records for descriptive 
      statistics and 10 records for quantitative synthesis. The results indicated that 
      the overall estimate of responders (percentage of subjects with increased lip 
      fullness by one point or higher) was 91% (ES = 0.91, 95% CI:0.85-0.96) 2 months 
      after injection. The rate of responders was 74% (ES = 0.74, 95% CI:0.66-0.82) and 
      46% (ES = 0.46, 95% CI:0.28-0.65) after 6 and 12 months, respectively. We 
      included 1,496 participants for estimating the event rates of AEs. The most 
      frequent treatment-related AEs were tenderness (88.8%), injection site swelling 
      (74.3%) and bruising (39.5%). Rare AEs included foreign body granulomas (0.6%), 
      herpes labialis (0.6%) and angioedema (0.3%). Conclusion: Our meta-analysis 
      revealed that lip augmentation with injectable HA is an efficient method for 
      increasing lip fullness for at least up to 6 months after augmentation. Moreover, 
      we found that most AEs of HA treatment were mild or moderate, but a small number 
      of serious adverse effects were also found. In conclusion, further well-designed 
      RCTs are still needed to make the presently available evidence stronger.
CI  - Copyright (c) 2021 Czumbel, Farkasdi, Gede, Miko, Csupor, Lukacs, Gaal, Kiss, Hegyi 
      and Varga.
FAU - Czumbel, Laszlo Mark
AU  - Czumbel LM
AD  - Department of Oral Biology, Faculty of Dentistry, Semmelweis University, 
      Budapest, Hungary.
FAU - Farkasdi, Sandor
AU  - Farkasdi S
AD  - Department of Oral Biology, Faculty of Dentistry, Semmelweis University, 
      Budapest, Hungary.
FAU - Gede, Noemi
AU  - Gede N
AD  - Institute for Translational Medicine, Medical School, University of Pecs, Pecs, 
      Hungary.
FAU - Miko, Alexandra
AU  - Miko A
AD  - Institute for Translational Medicine, Medical School, University of Pecs, Pecs, 
      Hungary.
FAU - Csupor, Dezso
AU  - Csupor D
AD  - Institute for Translational Medicine, Medical School, University of Pecs, Pecs, 
      Hungary.
AD  - Department of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Szeged, 
      Hungary.
FAU - Lukacs, Anita
AU  - Lukacs A
AD  - Department of Public Health, Faculty of Medicine, University of Szeged, Szeged, 
      Hungary.
AD  - Department of Physiology, Anatomy and Neuroscience, Faculty of Science and 
      Informatics, University of Szeged, Szeged, Hungary.
FAU - Gaal, Valeria
AU  - Gaal V
AD  - Department of Ophthalmology, Medical School, University of Pecs, Pecs, Hungary.
FAU - Kiss, Szabolcs
AU  - Kiss S
AD  - Institute for Translational Medicine, Medical School, University of Pecs, Pecs, 
      Hungary.
AD  - Doctoral School of Clinical Medicine, University of Szeged, Szeged, Hungary.
FAU - Hegyi, Peter
AU  - Hegyi P
AD  - Institute for Translational Medicine, Medical School, University of Pecs, Pecs, 
      Hungary.
FAU - Varga, Gabor
AU  - Varga G
AD  - Department of Oral Biology, Faculty of Dentistry, Semmelweis University, 
      Budapest, Hungary.
LA  - eng
PT  - Systematic Review
DEP - 20210806
PL  - Switzerland
TA  - Front Surg
JT  - Frontiers in surgery
JID - 101645127
PMC - PMC8377277
OTO - NOTNLM
OT  - adverse effects
OT  - dermal filler
OT  - effectiveness
OT  - hyaluronic acid
OT  - lip augmentation
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/08/24 06:00
MHDA- 2021/08/24 06:01
PMCR- 2021/08/06
CRDT- 2021/08/23 06:37
PHST- 2021/03/15 00:00 [received]
PHST- 2021/07/09 00:00 [accepted]
PHST- 2021/08/23 06:37 [entrez]
PHST- 2021/08/24 06:00 [pubmed]
PHST- 2021/08/24 06:01 [medline]
PHST- 2021/08/06 00:00 [pmc-release]
AID - 10.3389/fsurg.2021.681028 [doi]
PST - epublish
SO  - Front Surg. 2021 Aug 6;8:681028. doi: 10.3389/fsurg.2021.681028. eCollection 
      2021.