PMID- 34427217
OWN - NLM
STAT- MEDLINE
DCOM- 20210831
LR  - 20220426
IS  - 1998-3689 (Electronic)
IS  - 0301-4738 (Print)
IS  - 0301-4738 (Linking)
VI  - 69
IP  - 9
DP  - 2021 Sep
TI  - Multifocal electroretinography-assisted anatomical and functional evaluation of 
      subthreshold green laser in acute central serous chorioretinopathy.
PG  - 2341-2346
LID - 10.4103/ijo.IJO_3401_20 [doi]
AB  - PURPOSE: To compare observation versus subthreshold green laser (STL) in acute 
      central serous chorioretinopathy (CSC) in terms of anatomical and functional 
      outcomes. METHODS: Prospective randomized interventional study. 30 eyes with the 
      first episode of acute CSC underwent complete ophthalmologic examination, 
      measurement of best-corrected Snellen visual acuity (BCVA), contrast sensitivity 
      (CS), fundus fluorescein angiography (FFA), spectral-domain optical coherence 
      tomography (SD-OCT), and multifocal electroretinography (mfERG) at baseline. 
      Patients were randomized equally to group A (observation) or group B (STL using 
      532 nm wavelength applied to the leakage point). Outcome measures included BCVA, 
      CS, central foveal thickness (CFT), and mean macular thickness (MMT) on SD-OCT 
      and P1 amplitude and implicit time (IT) on mfERG. Patients were followed up for 6 
      months. RESULTS: Mean BCVA was comparable between the two groups on follow up; 
      however, mean CS was significantly higher in group B at 6 months (P = 0.032). CFT 
      was significantly lower in group B at 1 month (P = 0.001) and 3 months (P = 
      0.049); however, this difference was not maintained at 6 months (P = 0.265). P1 
      amplitude and IT in all 5 rings were comparable between the two groups at 
      baseline. On follow up, P1 amplitude of ring 1 became significantly higher in 
      group B at 3 months (P = 0.036) and 6 months (P = 0.022). CONCLUSION: Immediate 
      treatment of acute CSC with STL, as compared to conservative management, leads to 
      more rapid resolution on SD-OCT and superior functional outcomes as evidenced by 
      CS and mfERG.
FAU - Goel, Neha
AU  - Goel N
AD  - Department of Ophthalmology, Max Multi Speciality Centre, New Delhi, India.
FAU - Mehta, Aanchal
AU  - Mehta A
AD  - Department of Vitreoretina, ICARE Eye Hospital and Postgraduate Institute, NOIDA, 
      Uttar Pradesh, India.
FAU - Gupta, A K
AU  - Gupta AK
AD  - Department of Vitreoretina, ICARE Eye Hospital and Postgraduate Institute, NOIDA, 
      Uttar Pradesh, India.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - India
TA  - Indian J Ophthalmol
JT  - Indian journal of ophthalmology
JID - 0405376
SB  - IM
CIN - Indian J Ophthalmol. 2021 Sep;69(9):2347-2348. PMID: 34427218
CIN - Indian J Ophthalmol. 2021 Sep;69(9):2348-2349. PMID: 34427219
MH  - *Central Serous Chorioretinopathy/diagnosis/surgery
MH  - *Electroretinography
MH  - Fluorescein Angiography
MH  - Humans
MH  - Lasers
MH  - Prospective Studies
PMC - PMC8544059
OTO - NOTNLM
OT  - Acute central serous chorioretinopathy
OT  - contrast sensitivity
OT  - multifocal electroretinography
OT  - spectral-domain optical coherence tomography
OT  - subthreshold laser
COIS- None
EDAT- 2021/08/25 06:00
MHDA- 2021/09/01 06:00
PMCR- 2021/09/01
CRDT- 2021/08/24 09:21
PHST- 2021/08/24 09:21 [entrez]
PHST- 2021/08/25 06:00 [pubmed]
PHST- 2021/09/01 06:00 [medline]
PHST- 2021/09/01 00:00 [pmc-release]
AID - IndianJOphthalmol_2021_69_9_2341_324367 [pii]
AID - IJO-69-2341 [pii]
AID - 10.4103/ijo.IJO_3401_20 [doi]
PST - ppublish
SO  - Indian J Ophthalmol. 2021 Sep;69(9):2341-2346. doi: 10.4103/ijo.IJO_3401_20.