PMID- 34427225
OWN - NLM
STAT- MEDLINE
DCOM- 20210831
LR  - 20220531
IS  - 1998-3689 (Electronic)
IS  - 0301-4738 (Print)
IS  - 0301-4738 (Linking)
VI  - 69
IP  - 9
DP  - 2021 Sep
TI  - Role of spectral domain optical coherence tomography in the diagnosis and 
      prognosis of papilledema.
PG  - 2372-2377
LID - 10.4103/ijo.IJO_3269_20 [doi]
AB  - PURPOSE: The study of papilledema with a novel noninvasive technique such as 
      spectral domain-optical coherence tomography (SD-OCT) provides minute and 
      detailed cross-sectional changes thus giving an insight into the application of 
      biomechanical principles and pathophysiology of disc edema. METHODS: We measured 
      average retinal nerve fiber layer (RNFL) thickness and the retinal pigment 
      epithelium/Bruch's membrane (RPE/BM) angle at the temporal and nasal borders of 
      the neural canal opening (NCO) in 30 eyes with papilledema, 30 eyes with 
      papillitis, and 80 control eyes. The inward angulation was considered as positive 
      and the outward as negative. Follow-up was done at 1, 2, 3, and 6 months. The 
      main outcome measures are the average RNFL thickness and the RPE/BM angle. 
      RESULTS: 29 eyes (96.6%) with papilledema had a positive RPE/BM angle (+8.11 +/- 
      3.13). 29 eyes (96.6%) with papillitis had a negative RPE/BM angle (-1.04 +/- 
      3.27). On follow-up at 1 month, both RNFL thickness (P = 0.01) and RPE-BM angle 
      (P = 0.001) reduced significantly in eyes with papilledema; in eyes with 
      papillitis, there was a significant reduction in the RNFL thickness (P = 0.02), 
      but not in the RPE-BM angle (P > 0.05). RNFL thickness in papilledema cases 
      normalized at 3 months whereas RPE/BM normalized at 6 months of follow-up. To 
      detect papilledema, OCT has a sensitivity of 96.66% and specificity of 99.09% on 
      both nasal and temporal sides. CONCLUSION: After appropriate treatment, the 
      RPE/BM angle in papilledema decreased much later than the RNFL thickness. Hence, 
      the RPE/BM angle in papilledema (positive) can be used to differentiate it from 
      papillitis (negative) and also to monitor the activity of the disease.
FAU - Panyala, Rakesh
AU  - Panyala R
AD  - Consultant Pediatric Ophthalmology and Strabismus, MaxiVision Eye Hospital, 
      Karimnagar, India.
FAU - Sharma, Pradeep
AU  - Sharma P
AD  - Professor Head Strabismus, Pediatric Ophthalmology and Neuro-Ophthalmology, 
      AIIMS; Director Strabismus Pediatric and Neuro-Ophthalmology Centre for Sight, 
      New Delhi, India.
FAU - Sihota, Ramanjit
AU  - Sihota R
AD  - Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Saxena, Rohit
AU  - Saxena R
AD  - Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Prasad, Kameshwar
AU  - Prasad K
AD  - Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Phuljhele, Swati
AU  - Phuljhele S
AD  - Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Gurrala, Sneha
AU  - Gurrala S
AD  - MBBS, Kamineni Institute of Medical Sciences, Narketpally, Hyderabad, Telangana, 
      India.
FAU - Bhaskaran, Karthika
AU  - Bhaskaran K
AD  - Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi, 
      India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Ophthalmol
JT  - Indian journal of ophthalmology
JID - 0405376
SB  - IM
MH  - Humans
MH  - Nerve Fibers
MH  - *Optic Disk
MH  - *Papilledema/diagnosis
MH  - Prognosis
MH  - Retinal Ganglion Cells
MH  - Tomography, Optical Coherence
PMC - PMC8544041
OTO - NOTNLM
OT  - Idiopathic intracranial hypertension
OT  - RNFL thickness
OT  - RPE/BM angle
OT  - papilledema
OT  - papillitis
OT  - spectral domain OCT
COIS- None
EDAT- 2021/08/25 06:00
MHDA- 2021/09/01 06:00
PMCR- 2021/09/01
CRDT- 2021/08/24 09:21
PHST- 2021/08/24 09:21 [entrez]
PHST- 2021/08/25 06:00 [pubmed]
PHST- 2021/09/01 06:00 [medline]
PHST- 2021/09/01 00:00 [pmc-release]
AID - IndianJOphthalmol_2021_69_9_2372_324363 [pii]
AID - IJO-69-2372 [pii]
AID - 10.4103/ijo.IJO_3269_20 [doi]
PST - ppublish
SO  - Indian J Ophthalmol. 2021 Sep;69(9):2372-2377. doi: 10.4103/ijo.IJO_3269_20.