PMID- 34427329
OWN - NLM
STAT- MEDLINE
DCOM- 20220412
LR  - 20220504
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 132
IP  - 5
DP  - 2022 May
TI  - Long-Term Voice Outcomes Following Cricotracheal Resection for Subglottic 
      Stenosis: A Retrospective Analysis.
PG  - 1054-1060
LID - 10.1002/lary.29827 [doi]
AB  - OBJECTIVES/HYPOTHESIS: Cricotracheal resection (CTR) is an effective treatment 
      for refractory idiopathic subglottic stenosis (iSGS) but is associated with 
      persistent dysphonia. Outcomes were measured longitudinally to characterize how 
      patients' voices and self-perceived voice handicaps changed after CTR. STUDY 
      DESIGN: Retrospective case-series. METHODS: We conducted a retrospective cohort 
      study of patients with refractory iSGS treated by CTR from 2006 to 2017. Voice 
      Handicap Index (VHI), Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V), 
      and acoustic analysis were prospectively collected preoperatively and 
      postoperatively at 1, 3, 6, 12, and 24-month intervals. A linear mixed model was 
      used to evaluate temporal change. RESULTS: Thirty-three patients (97% female) 
      were included. VHI scores increased significantly from baseline preoperative 
      score (27.2 +/- 22.7) to a mean value of 44.3 +/- 25.6 (P < .001) 1-month 
      postoperatively but decreased below preoperative scores after 2 years 
      (18.8 +/- 11.9, P = .795). Mean fundamental frequency (F0) values in speech 
      decreased significantly from 192.0 +/- 24.9 Hz preoperatively to 167.1 +/- 19.8 Hz at 
      a 2-year follow-up (P = .002), with a nadir value at 1-month postoperatively 
      (148.4 +/- 20.5, P < .001). CAPE-V scores increased significantly from preoperative 
      to 1-month postoperative (3.0 +/- 2.3 vs. 21.9 +/- 17.3, P < .001) but returned 
      toward baseline values at 24 months after CTR (6.9 +/- 4.8, P = .027). CAPE-V 
      measurements postoperatively were correlated with VHI and F0 (Pearson 
      coefficient = 0.54 (VHI), -0.46 (F0), P < .001). CONCLUSIONS: Following CTR, mean 
      F0 values were significantly and consistently lower but did increase over time, 
      correlating with patients' improving VHI and CAPE-V scores. VHI values indicate 
      that patient's perception of their voice is not significantly impacted in long 
      term. These results provide a framework to counsel patients about long term voice 
      expectations. LEVEL OF EVIDENCE: 4 Laryngoscope, 132:1054-1060, 2022.
CI  - (c) 2021 The American Laryngological, Rhinological and Otological Society, Inc.
FAU - Compton, Evan C
AU  - Compton EC
AUID- ORCID: 0000-0001-8956-0431
AD  - Section of Otolaryngology-Head and Neck Surgery, Department of Surgery, Cumming 
      School of Medicine, University of Calgary, Calgary, Alberta, Canada.
FAU - Beveridge, Shari
AU  - Beveridge S
AD  - Calgary Voice Program, Alberta Health Services, Calgary, Alberta, Canada.
FAU - Andreassen, Meri
AU  - Andreassen M
AD  - Calgary Voice Program, Alberta Health Services, Calgary, Alberta, Canada.
FAU - Gelfand, Gary
AU  - Gelfand G
AD  - Section of Thoracic Surgery, Department of Surgery, Cumming School of Medicine, 
      University of Calgary, Calgary, Alberta, Canada.
FAU - McFadden, Sean
AU  - McFadden S
AD  - Section of Thoracic Surgery, Department of Surgery, Cumming School of Medicine, 
      University of Calgary, Calgary, Alberta, Canada.
FAU - Bosch, Doug
AU  - Bosch D
AD  - Section of Otolaryngology-Head and Neck Surgery, Department of Surgery, Cumming 
      School of Medicine, University of Calgary, Calgary, Alberta, Canada.
FAU - Randall, Derrick R
AU  - Randall DR
AUID- ORCID: 0000-0002-5542-1916
AD  - Section of Otolaryngology-Head and Neck Surgery, Department of Surgery, Cumming 
      School of Medicine, University of Calgary, Calgary, Alberta, Canada.
LA  - eng
PT  - Journal Article
DEP - 20210824
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Constriction, Pathologic/complications
MH  - Disability Evaluation
MH  - *Dysphonia/complications/surgery
MH  - Female
MH  - Humans
MH  - *Laryngostenosis/complications/surgery
MH  - Male
MH  - Retrospective Studies
MH  - Voice Quality
OTO - NOTNLM
OT  - Cricotracheal resection
OT  - Voice Handicap Index
OT  - dysphonia
OT  - idiopathic
OT  - subglottic stenosis
EDAT- 2021/08/25 06:00
MHDA- 2022/04/13 06:00
CRDT- 2021/08/24 09:24
PHST- 2021/07/13 00:00 [revised]
PHST- 2021/03/12 00:00 [received]
PHST- 2021/08/06 00:00 [accepted]
PHST- 2021/08/25 06:00 [pubmed]
PHST- 2022/04/13 06:00 [medline]
PHST- 2021/08/24 09:24 [entrez]
AID - 10.1002/lary.29827 [doi]
PST - ppublish
SO  - Laryngoscope. 2022 May;132(5):1054-1060. doi: 10.1002/lary.29827. Epub 2021 Aug 
      24.