PMID- 34427339
OWN - NLM
STAT- MEDLINE
DCOM- 20211124
LR  - 20211124
IS  - 1365-2885 (Electronic)
IS  - 0140-7783 (Linking)
VI  - 44
IP  - 6
DP  - 2021 Nov
TI  - Pharmacokinetics of furosemide in goats following intravenous, intramuscular, and 
      subcutaneous administrations.
PG  - 961-966
LID - 10.1111/jvp.13009 [doi]
AB  - Furosemide, a loop diuretic drug, is recommended for use in cases of edema, 
      ascites, congestive heart failure, toxicosis, and acute renal failure in goats. 
      However, its pharmacokinetics and bioavailability have not been reported yet in 
      this species. The aim of this study was to determine the pharmacokinetics and 
      bioavailability of furosemide in goats following intravenous (IV), intramuscular 
      (IM), and subcutaneous (SC) administrations at a dose of 2.5 mg/kg. Six 
      clinically healthy goats received furosemide by each route in a three-way 
      crossover pharmacokinetic design with a 15-day washout period between 
      administrations. The plasma concentrations of furosemide were determined using 
      the high-performance liquid chromatography-UV method and analyzed by 
      non-compartmental analysis. The elimination half-life following IV, IM, and SC 
      administration was 0.71 (0.67-0.76) h, 0.69 (0.61-0.74) h, and 0.70 
      (0.67-0.79) h, respectively. The volume of distribution at steady state and total 
      clearance for the IV route were 0.17 (0.16-0.19) L/kg and 0.30 
      (0.27-0.33) L/h/kg, respectively. The peak plasma concentrations of furosemide 
      following IM and SC administrations were 11.19 (10.33-11.95) and 6.49 
      (5.92-7.00) mug/ml at 0.23 (0.16-0.25) and 0.39 (0.33-0.42) h, respectively. The 
      bioavailability was 109.84 (104.92-116.99)% and 70.80 (55.77-86.67)% for the IM 
      and SC routes, respectively. The pharmacokinetics of furosemide following the IV, 
      IM, and SC administrations in goats demonstrated significant differences, which 
      may have clinical and toxicological implications requiring further 
      investigations.
CI  - (c) 2021 John Wiley & Sons Ltd.
FAU - Cetin, Gul
AU  - Cetin G
AUID- ORCID: 0000-0002-9408-0042
AD  - Department of Pharmacology, Faculty of Pharmacy, University of Erzincan Binali 
      Yildirim, Erzincan, Turkey.
FAU - Corum, Orhan
AU  - Corum O
AUID- ORCID: 0000-0003-3168-2510
AD  - Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, 
      University of Kastamonu, Kastamonu, Turkey.
FAU - Durna Corum, Duygu
AU  - Durna Corum D
AUID- ORCID: 0000-0003-1567-991X
AD  - Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, 
      University of Kastamonu, Kastamonu, Turkey.
FAU - Atik, Orkun
AU  - Atik O
AUID- ORCID: 0000-0003-2411-7492
AD  - Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, 
      University of Afyon Kocatepe, Afyonkarahisar, Turkey.
FAU - Turk, Erdinc
AU  - Turk E
AUID- ORCID: 0000-0003-1735-1774
AD  - Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, 
      University of Hatay Mustafa Kemal, Hatay, Turkey.
FAU - Tekeli, Ibrahim Ozan
AU  - Tekeli IO
AUID- ORCID: 0000-0002-6845-2279
AD  - Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, 
      University of Hatay Mustafa Kemal, Hatay, Turkey.
FAU - Uney, Kamil
AU  - Uney K
AUID- ORCID: 0000-0002-8674-4873
AD  - Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, 
      University of Selcuk, Konya, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20210824
PL  - England
TA  - J Vet Pharmacol Ther
JT  - Journal of veterinary pharmacology and therapeutics
JID - 7910920
RN  - 7LXU5N7ZO5 (Furosemide)
SB  - IM
MH  - Administration, Intravenous/veterinary
MH  - Animals
MH  - Area Under Curve
MH  - Biological Availability
MH  - *Furosemide
MH  - *Goats
MH  - Half-Life
MH  - Injections, Intramuscular/veterinary
MH  - Injections, Intravenous/veterinary
MH  - Injections, Subcutaneous/veterinary
OTO - NOTNLM
OT  - Furosemide
OT  - bioavailability
OT  - goats
OT  - pharmacokinetics
EDAT- 2021/08/25 06:00
MHDA- 2021/11/25 06:00
CRDT- 2021/08/24 09:26
PHST- 2021/07/02 00:00 [revised]
PHST- 2021/02/17 00:00 [received]
PHST- 2021/07/18 00:00 [accepted]
PHST- 2021/08/25 06:00 [pubmed]
PHST- 2021/11/25 06:00 [medline]
PHST- 2021/08/24 09:26 [entrez]
AID - 10.1111/jvp.13009 [doi]
PST - ppublish
SO  - J Vet Pharmacol Ther. 2021 Nov;44(6):961-966. doi: 10.1111/jvp.13009. Epub 2021 
      Aug 24.