PMID- 34428026
OWN - NLM
STAT- MEDLINE
DCOM- 20220103
LR  - 20240226
IS  - 1520-5010 (Electronic)
IS  - 0893-228X (Linking)
VI  - 34
IP  - 9
DP  - 2021 Sep 20
TI  - Polybrominated Diphenyl Ether Quinone Exposure Induces Atherosclerosis 
      Progression via CD36-Mediated Lipid Accumulation, NLRP3 Inflammasome Activation, 
      and Pyroptosis.
PG  - 2125-2134
LID - 10.1021/acs.chemrestox.1c00214 [doi]
AB  - Polybrominated diphenyl ethers (PBDEs) are used worldwide in brominated flame 
      retardants. Although due to the forbiddance of their application, PBDEs 
      continuously exist in the environment due to their persistence. Therefore, it is 
      important to expand the understanding of their potential toxicities and human 
      risks. The underlying cardiovascular toxicological mechanisms of PBDEs are still 
      largely unknown. Our previous studies indicated that PBDE quinone-type metabolite 
      (PBDEQ) exposure causes reactive oxygen species (ROS)-driven cytotoxicity and 
      various types of programmed cell death. Here, we first reported PBDEQ exposure 
      induces atherosclerosis progression in bone marrow-derived macrophages (BMDMs) 
      isolated from wild-type C57BL/6 or CD36(-/-) mice and J774A.1 macrophage models. 
      First, we found that PBDEQ exposure induced lipid accumulation in oxidized 
      low-density lipid (Ox-LDL)-treated J774A.1 macrophages. Consistently, in J774A.1 
      macrophages, PBDEQ exposure resulted in NLR family pyrin domain containing 3 
      (NLRP3) inflammasome activation and pyroptosis. CD36, a scavenger receptor 
      responsible for the mediation of Ox-LDL uptake, was upregulated upon PBDEQ 
      treatment. On the contrary, genetic knockout of CD36 or CD36 silencing by small 
      interfering RNA efficiently attenuates PBDEQ-promoted lipid accumulation in BMDMs 
      and J774A.1 macrophages. These findings highlight the effect of CD36 on the 
      cardiovascular toxicity of PBDEs, which provides a better understanding of the 
      pro-atherosclerosis effect of PBDEs.
FAU - Wang, Yuting
AU  - Wang Y
AD  - Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of 
      Education, College of Pharmaceutical Sciences, Southwest University, 2 Tiansheng 
      Road, Beibei District, Chongqing 400715, China.
FAU - Fang, Changyu
AU  - Fang C
AD  - Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of 
      Education, College of Pharmaceutical Sciences, Southwest University, 2 Tiansheng 
      Road, Beibei District, Chongqing 400715, China.
FAU - Xu, Lei
AU  - Xu L
AD  - Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of 
      Education, College of Pharmaceutical Sciences, Southwest University, 2 Tiansheng 
      Road, Beibei District, Chongqing 400715, China.
FAU - Yang, Bingwei
AU  - Yang B
AD  - Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of 
      Education, College of Pharmaceutical Sciences, Southwest University, 2 Tiansheng 
      Road, Beibei District, Chongqing 400715, China.
FAU - Song, Erqun
AU  - Song E
AUID- ORCID: 0000-0003-4026-090X
AD  - Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of 
      Education, College of Pharmaceutical Sciences, Southwest University, 2 Tiansheng 
      Road, Beibei District, Chongqing 400715, China.
FAU - Song, Yang
AU  - Song Y
AUID- ORCID: 0000-0001-7716-9216
AD  - Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of 
      Education, College of Pharmaceutical Sciences, Southwest University, 2 Tiansheng 
      Road, Beibei District, Chongqing 400715, China.
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, 18 Shuangqing 
      Road, Haidian District, Beijing 100085, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210824
PL  - United States
TA  - Chem Res Toxicol
JT  - Chemical research in toxicology
JID - 8807448
RN  - 0 (Benzoquinones)
RN  - 0 (CD36 Antigens)
RN  - 0 (Cd36 protein, mouse)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Inflammasomes)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (Nlrp3 protein, mouse)
SB  - IM
MH  - Animals
MH  - Atherosclerosis/*etiology
MH  - Benzoquinones/*toxicity
MH  - CD36 Antigens/metabolism
MH  - Cell Line
MH  - Foam Cells/drug effects
MH  - Halogenated Diphenyl Ethers/*toxicity
MH  - Inflammasomes/*drug effects
MH  - Lipid Metabolism/*drug effects
MH  - Male
MH  - Mice, Inbred C57BL
MH  - NLR Family, Pyrin Domain-Containing 3 Protein/metabolism
MH  - Pyroptosis/*drug effects
MH  - Mice
EDAT- 2021/08/25 06:00
MHDA- 2022/01/04 06:00
CRDT- 2021/08/24 17:11
PHST- 2021/08/25 06:00 [pubmed]
PHST- 2022/01/04 06:00 [medline]
PHST- 2021/08/24 17:11 [entrez]
AID - 10.1021/acs.chemrestox.1c00214 [doi]
PST - ppublish
SO  - Chem Res Toxicol. 2021 Sep 20;34(9):2125-2134. doi: 
      10.1021/acs.chemrestox.1c00214. Epub 2021 Aug 24.