PMID- 34428976
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20211025
IS  - 2280-8000 (Electronic)
IS  - 2280-8000 (Linking)
VI  - 19
DP  - 2021 Jan-Dec
TI  - Enhanced antibacterial properties and promoted cell proliferation in glass 
      ionomer cement by modified with fluorinated graphene-doped.
PG  - 22808000211037487
LID - 10.1177/22808000211037487 [doi]
AB  - In this study, we aimed to improve the properties of conventional glass ionomer 
      cement (GIC), including mechanical properties, wear resistance, antibacterial 
      properties and biological activity, by adding fluorinated graphene (FG). 
      Composites of synthesised FG and GIC were examined after being combined at 
      different mass proportions (0, 0.5, 1.0 and 2.0 wt%). The microstructure and 
      morphology of FG prepared via the hydrothermal method was characterised using 
      scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). 
      The FG/GIC composite was obtained through the blending method and characterised 
      using SEM. Then, the Vickers microhardness and the wear property of the FG/GIC 
      composite-imitated brushing was measured. The plate count and dilution methods 
      (10-fold) were adopted to investigate the antibacterial properties of FG/GIC by 
      incubating Escherichia coli and Staphylococcus aureus. The biocompatibility of 
      FG/GIC containing the adhesion and cytotoxicity of mouse fibroblast cells (L929) 
      was estimated by the MTT and acridine orange (AO) fluorescent staining. Our 
      results demonstrated that the hardness and abrasive wear resistance of the 
      composites increased, and the microhardness parameter changes exhibited a gradual 
      increase as the concentration continued to increase. A 2.0 wt% FG concentration 
      could effectively improve the bacterial inhibition performance of GIC and was 
      directly proportional to the concentration of FG. The composite materials showed 
      no apparent cytotoxicity on normal L929 cells compared to the control group, and 
      the materials exhibited no cytotoxic effect compared to traditional GIC. Thus, 
      FG/GIC has potential therapeutic value in the field of dental treatment.
FAU - Liu, Ruimin
AU  - Liu R
AD  - Department of Oral and Maxillofacial Surgery, Gansu Provincial Hospital, Lanzhou, 
      PR China.
FAU - Wang, Errui
AU  - Wang E
AD  - Department of Stomatology, Lanzhou University, Lanzhou, PR China.
FAU - Guo, Yumeng
AU  - Guo Y
AD  - Department of Stomatology, Lanzhou University, Lanzhou, PR China.
FAU - Zhou, Qiaozhen
AU  - Zhou Q
AD  - Department of Stomatology, Lanzhou University, Lanzhou, PR China.
FAU - Zheng, Yayuan
AU  - Zheng Y
AD  - Department of Stomatology, Lanzhou University, Lanzhou, PR China.
FAU - Zhai, Junkai
AU  - Zhai J
AD  - Department of Stomatology, Lanzhou University, Lanzhou, PR China.
FAU - Zhang, Kailiang
AU  - Zhang K
AD  - Department of Stomatology, Lanzhou University, Lanzhou, PR China.
FAU - Zhang, Baoping
AU  - Zhang B
AUID- ORCID: 0000-0003-4468-5091
AD  - Department of Stomatology, Lanzhou University, Lanzhou, PR China.
AD  - Institute of Biomechanics and Medical Engineering, Lanzhou University, Lanzhou, 
      PR China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Appl Biomater Funct Mater
JT  - Journal of applied biomaterials & functional materials
JID - 101586617
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Glass Ionomer Cements)
RN  - 7782-42-5 (Graphite)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/pharmacology
MH  - Cell Proliferation
MH  - *Glass Ionomer Cements/pharmacology
MH  - *Graphite
MH  - Materials Testing
MH  - Mice
OTO - NOTNLM
OT  - Glass ionomer cement
OT  - antibacterial property
OT  - cellular compatibility
OT  - fluorinated graphene
OT  - tooth decay
EDAT- 2021/08/26 06:00
MHDA- 2021/10/26 06:00
CRDT- 2021/08/25 05:28
PHST- 2021/08/25 05:28 [entrez]
PHST- 2021/08/26 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
AID - 10.1177/22808000211037487 [doi]
PST - ppublish
SO  - J Appl Biomater Funct Mater. 2021 Jan-Dec;19:22808000211037487. doi: 
      10.1177/22808000211037487.