PMID- 34429647
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220426
IS  - 1178-7090 (Print)
IS  - 1178-7090 (Electronic)
IS  - 1178-7090 (Linking)
VI  - 14
DP  - 2021
TI  - Expression of Substance P and Nerve Growth Factor in Degenerative Long Head of 
      Biceps Tendon in Patients with Painful Rotator Cuff Tear.
PG  - 2481-2490
LID - 10.2147/JPR.S320811 [doi]
AB  - PURPOSE: Degenerative long head of biceps tendon (LHBT) has been recognized as a 
      notable pain source in patients with rotator cuff tear (RCT). Tenotomy or 
      tenodesis of LHBT is frequently indicated together with arthroscopic rotator cuff 
      repair (ARCR) aiming for complete pain relief; however, it has not been fully 
      investigated whether resected LHBT is really a source of pain. The purpose of 
      this study was to investigate expression levels of pain-associated mediators in 
      LHBT and its association with preoperative pain profiles. METHODS: Twenty-seven 
      RCT patients who underwent ARCR with LHBT resection were included. Each LHBT was 
      resected due to its abnormal arthroscopic findings including tenosynovitis, 
      hypertrophy, and partial tear. Worst macroscopic lesion of the LHBT was obtained, 
      and expression levels of substance P (SP) and nerve growth factor (NGF) were 
      evaluated using enzyme-linked immunosorbent assay (ELISA). Ten healthy knee 
      flexor tendons were analyzed as non-degenerative samples. Preoperatively, 
      subjective shoulder pain VAS and pain duration were investigated. Conventional 
      LHBT pain provocation tests (Speed, Yergason, O'Brien) were performed. Pressure 
      pain threshold (PPT) of bilateral LHBT on the groove was recorded. RESULTS: 
      Levels of SP and NGF expression were significantly higher compared with 
      non-degenerative tendons (P<0.01). Shoulder pain VAS and pain duration were not 
      directly associated with SP and NGF expression level. Patients with positive 
      O'Brien test expressed greater SP than negative patients (P=0.001). Significant 
      negative correlation between the PPT ratio (ipsilateral/contralateral) and SP 
      expression level was observed (r=-0.453, P=0.034). CONCLUSION: Greater expression 
      of SP and NGF in degenerative LHBT supported our hypothesis that it would be a 
      pain source in RCT patients. SP was likely to be expressed highly in patients 
      with localized pressure pain hypersensitivity and positive O'Brien test (ie, 
      altered mechanistic pain profile of LHBT), which may help when considering 
      simultaneous LHBT resection during ARCR. CLINICAL REGISTRATION: UMIN000023943.
CI  - (c) 2021 Izumi et al.
FAU - Izumi, Masashi
AU  - Izumi M
AUID- ORCID: 0000-0002-8592-6069
AD  - Department of Orthopaedic Surgery, Kochi Medical School, Kochi University, 
      Nankoku-City, Japan.
FAU - Harada, Yohei
AU  - Harada Y
AD  - Department of Orthopaedic Surgery, Aichi Medical University, Nagakute, Japan.
AD  - Department of Orthopaedic Surgery, Graduate School of Biomedical and Health 
      Sciences, Hiroshima University, Hiroshima, Japan.
FAU - Kajita, Yukihiro
AU  - Kajita Y
AD  - Department of Orthopaedic Surgery, Aichi Medical University, Nagakute, Japan.
FAU - Muramatsu, Yoshitaka
AU  - Muramatsu Y
AD  - Department of Orthopaedic Surgery, Aichi Medical University, Nagakute, Japan.
AD  - Department of Orthopaedic Surgery, Saiseikai Futsukaichi Hospital, Futsukaichi, 
      Japan.
FAU - Morimoto, Toru
AU  - Morimoto T
AD  - Department of Orthopaedic Surgery, Kochi Medical School, Kochi University, 
      Nankoku-City, Japan.
FAU - Morisawa, Yutaka
AU  - Morisawa Y
AD  - Department of Orthopaedic Surgery, Aki General Hospital, Aki, Japan.
FAU - Iwahori, Yusuke
AU  - Iwahori Y
AD  - Department of Orthopaedic Surgery, Aichi Medical University, Nagakute, Japan.
AD  - Department of Orthopaedic Surgery, Sports Medicine and Joint Center, Asahi 
      Hospital, Kasugai, Japan.
FAU - Ikeuchi, Masahiko
AU  - Ikeuchi M
AD  - Department of Orthopaedic Surgery, Kochi Medical School, Kochi University, 
      Nankoku-City, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210816
PL  - New Zealand
TA  - J Pain Res
JT  - Journal of pain research
JID - 101540514
PMC - PMC8379684
OTO - NOTNLM
OT  - long head of biceps tendon
OT  - nerve growth factor
OT  - pain
OT  - pressure pain threshold
OT  - substance P
OT  - tendinopathy
COIS- The authors report no conflict of interest in this work.
EDAT- 2021/08/26 06:00
MHDA- 2021/08/26 06:01
PMCR- 2021/08/16
CRDT- 2021/08/25 06:21
PHST- 2021/05/20 00:00 [received]
PHST- 2021/07/27 00:00 [accepted]
PHST- 2021/08/25 06:21 [entrez]
PHST- 2021/08/26 06:00 [pubmed]
PHST- 2021/08/26 06:01 [medline]
PHST- 2021/08/16 00:00 [pmc-release]
AID - 320811 [pii]
AID - 10.2147/JPR.S320811 [doi]
PST - epublish
SO  - J Pain Res. 2021 Aug 16;14:2481-2490. doi: 10.2147/JPR.S320811. eCollection 2021.