PMID- 34432937
OWN - NLM
STAT- MEDLINE
DCOM- 20220314
LR  - 20220314
IS  - 1468-1293 (Electronic)
IS  - 1464-2662 (Linking)
VI  - 23
IP  - 1
DP  - 2022 Jan
TI  - Study of natural product adverse events in adult HIV-infected patients in Canada.
PG  - 29-38
LID - 10.1111/hiv.13155 [doi]
AB  - INTRODUCTION: Many individuals living with HIV use natural health products (NHPs) 
      in an effort to decrease medication side effects and to enhance overall 
      well-being. METHODS: An active surveillance study of adult patients (>/= 18 years) 
      with HIV was conducted between 2012 and 2014 to detect prescription drug and NHP 
      use and associated adverse events (AEs) in the last month. RESULTS: Of the 167 
      participants, 85 (50.9%) took prescription medications only, three (1.8%) took 
      NHPs only, 75 (44.9%) took NHPs and prescription medications concurrently, and 
      four (2.4%) took neither. Patients who used both prescription drugs and NHPs 
      concurrently were more than three times more likely to experience an AE compared 
      with those who used prescription drugs only (OR, P = 0.003, 95% CI: 1.47-6.91). 
      CONCLUSIONS: Increased AEs are reported in patients with HIV who combine NHPs and 
      prescription medications, and no serious AEs were reported. Active surveillance 
      was found to be feasible in this clinical setting.
CI  - (c) 2021 British HIV Association.
FAU - Sparks, Emma
AU  - Sparks E
AD  - Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
FAU - Zorzela, Liliane
AU  - Zorzela L
AD  - Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
FAU - Necyk, Candace
AU  - Necyk C
AD  - Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, 
      Alberta, Canada.
FAU - Hughes, Christine
AU  - Hughes C
AD  - Department of Pediatrics, Medicine and Psychiatry, University of Alberta, 
      Edmonton, Alberta, Canada.
FAU - Vohra, Sunita
AU  - Vohra S
AUID- ORCID: 0000-0002-6210-7933
AD  - Department of Pediatrics, Medicine and Psychiatry, University of Alberta, 
      Edmonton, Alberta, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210825
PL  - England
TA  - HIV Med
JT  - HIV medicine
JID - 100897392
RN  - 0 (Biological Products)
RN  - 0 (Prescription Drugs)
SB  - IM
MH  - Adult
MH  - *Biological Products/adverse effects
MH  - Canada/epidemiology
MH  - *Drug-Related Side Effects and Adverse Reactions/epidemiology
MH  - *HIV Infections/drug therapy
MH  - Humans
MH  - *Prescription Drugs
OTO - NOTNLM
OT  - HIV
OT  - adverse events
OT  - antiretroviral
OT  - natural health products
OT  - pharmacovigilance
EDAT- 2021/08/26 06:00
MHDA- 2022/03/15 06:00
CRDT- 2021/08/25 17:32
PHST- 2021/07/15 00:00 [received]
PHST- 2021/07/23 00:00 [accepted]
PHST- 2021/08/26 06:00 [pubmed]
PHST- 2022/03/15 06:00 [medline]
PHST- 2021/08/25 17:32 [entrez]
AID - 10.1111/hiv.13155 [doi]
PST - ppublish
SO  - HIV Med. 2022 Jan;23(1):29-38. doi: 10.1111/hiv.13155. Epub 2021 Aug 25.