PMID- 34433425
OWN - NLM
STAT- MEDLINE
DCOM- 20210827
LR  - 20210829
IS  - 1471-230X (Electronic)
IS  - 1471-230X (Linking)
VI  - 21
IP  - 1
DP  - 2021 Aug 25
TI  - Glucocorticoids in acute pancreatitis: a propensity score matching analysis.
PG  - 331
LID - 10.1186/s12876-021-01907-1 [doi]
LID - 331
AB  - BACKGROUND: There are few reports about the effect of glucocorticoids in the 
      treatment of acute pancreatitis in humans. This study aims to evaluate the effect 
      of glucocorticoids in the treatment of acute pancreatitis by propensity score 
      matching analysis. RESULTS: Acute pancreatitis patients admitted between 2014 and 
      2019 were collected from the database and analyzed. Included patients were 
      divided into the glucocorticoids-used group (GC group) and the 
      non-glucocorticoids-used group (NGC group) according to whether glucocorticoids 
      were used. A total of 818 eligible patients were included in the final analysis. 
      Seventy-six patients were treated with glucocorticoids, and 742 patients were 
      treated without glucocorticoids. Before propensity score matching, the 
      triglyceride levels (38.2 +/- 18.5 vs. 20.2 +/- 16.8, P < 0.05) and Acute Physiology 
      and Chronic Health Evaluation II (APACHE II) scores (7.1 +/- 2.5 vs. 4.5 +/- 2.1, 
      P < 0.05) at admission were significantly higher in the GC group than in the NGC 
      group. The incidence of multi-organ failure (33.3% vs. 11.9%, P < 0.05) was 
      significantly higher in the GC group than in the NGC group. Patients in the GC 
      group showed a positive balance of fluid intake and output over 72 h. After 1:1 
      propensity score matching, 59 patients from each group (GC and NGC) were included 
      in the analysis. There were no significant differences in age, sex, body mass 
      index, triglycerides, or APACHE II scores between the two groups (P > 0.05), and 
      the patients' clinical outcomes were reversed. The proportion of patients with 
      organ failure (40.7% vs. 52.5%, p < 0.05) and multi-organ failure (35.0% vs. 
      67.7%, P < 0.05) was significantly lower in the GC group than in the NGC group. 
      Furthermore, patients in the GC group had significantly shorter lengths of 
      hospital stay (12.9 +/- 5.5 vs. 16.3 +/- 7.7, P < 0.05) and costs 
      (25,348.4 +/- 2512.6vs. 32,421.7 +/- 2813.3, P < 0.05) than those in the NGC group. 
      CONCLUSIONS: This study presents preliminary confirmation of the beneficial 
      effect of glucocorticoids in the treatment of acute pancreatitis. More 
      high-quality prospective studies are needed in the future.
CI  - (c) 2021. The Author(s).
FAU - Wang, Meng
AU  - Wang M
AD  - Department of Traditional Chinese Medicine, General Hospital of Western Theater 
      Command (Chengdu Military General Hospital), Chengdu, China.
FAU - Jiang, Zongxing
AU  - Jiang Z
AD  - Department of General Surgery, General Hospital of Western Theater Command 
      (Chengdu Military General Hospital), Chengdu, 613000, China.
FAU - Liang, Hongyin
AU  - Liang H
AD  - Department of General Surgery, General Hospital of Western Theater Command 
      (Chengdu Military General Hospital), Chengdu, 613000, China. lianghy1212@126.com.
LA  - eng
PT  - Journal Article
DEP - 20210825
PL  - England
TA  - BMC Gastroenterol
JT  - BMC gastroenterology
JID - 100968547
RN  - 0 (Glucocorticoids)
SB  - IM
MH  - APACHE
MH  - Acute Disease
MH  - *Glucocorticoids/therapeutic use
MH  - Humans
MH  - *Pancreatitis/drug therapy
MH  - Propensity Score
PMC - PMC8386156
OTO - NOTNLM
OT  - Acute pancreatitis
OT  - Glucocorticoids
OT  - Hypertriglyceridemic
OT  - Propensity score matching analysis
COIS- The authors declare that they have no competing interests.
EDAT- 2021/08/27 06:00
MHDA- 2021/08/28 06:00
PMCR- 2021/08/25
CRDT- 2021/08/26 05:29
PHST- 2021/04/12 00:00 [received]
PHST- 2021/08/14 00:00 [accepted]
PHST- 2021/08/26 05:29 [entrez]
PHST- 2021/08/27 06:00 [pubmed]
PHST- 2021/08/28 06:00 [medline]
PHST- 2021/08/25 00:00 [pmc-release]
AID - 10.1186/s12876-021-01907-1 [pii]
AID - 1907 [pii]
AID - 10.1186/s12876-021-01907-1 [doi]
PST - epublish
SO  - BMC Gastroenterol. 2021 Aug 25;21(1):331. doi: 10.1186/s12876-021-01907-1.