PMID- 34433894
OWN - NLM
STAT- MEDLINE
DCOM- 20211104
LR  - 20211104
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Aug 25
TI  - Characterizing right-angled vessel in macular telangiectasia type 2 with 
      structural optical coherence tomography.
PG  - 17198
LID - 10.1038/s41598-021-96789-4 [doi]
LID - 17198
AB  - We investigated the structural findings on spectral-domain optical coherence 
      tomography (SD-OCT) related to the presence of right-angled vessels (RAV) in 
      patients with macular telangiectasia (MacTel) type 2 with severity 3 in Korea. A 
      retrospective multicenter cross-sectional study was conducted in six tertiary 
      hospitals in Korea; the study included 116 MacTel type 2 eyes with severity 3. 
      The SD-OCT findings were compared between eyes with RAV on fundus photography or 
      fluorescein angiography and those without RAV. Logistic regression was performed 
      to determine factors associated with the presence of RAV. Fifty eyes presented 
      with RAV and 61 eyes without RAV. More eyes presented with only inner retinal 
      (IR) cavities on SD-OCT among eyes without RAV than among those with RAV 
      (P < 0.001). However, eyes with RAV presented with IR disorganization, outer 
      retinal (OR) cavity, and ellipsoid zone (EZ) disruption more frequently than eyes 
      without RAV did (all P < 0.001). These SD-OCT findings were significantly 
      associated with the presence of RAV. The presence of RAV was closely related to 
      IR disorganization, OR cavities, and EZ disruption on SD-OCT. These findings 
      suggest an advanced phase of MacTel type 2.
CI  - (c) 2021. The Author(s).
FAU - Chung, Yoo-Ri
AU  - Chung YR
AD  - Department of Ophthalmology, Ajou University School of Medicine, 164 World 
      Cup-ro, Yeongtong-gu, Suwon, 16499, Korea.
FAU - Kim, Young Ho
AU  - Kim YH
AD  - Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
FAU - Oh, Jaeryung
AU  - Oh J
AD  - Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
FAU - Kim, Seong-Woo
AU  - Kim SW
AD  - Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
FAU - Lee, Christopher Seungkyu
AU  - Lee CS
AD  - Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
AD  - Institute of Vision Research, Yonsei University College of Medicine, Seoul, 
      Korea.
AD  - Institute of Human Barrier Research, Yonsei University College of Medicine, 
      Seoul, Korea.
FAU - Yun, Cheolmin
AU  - Yun C
AD  - Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
FAU - Lee, Boram
AU  - Lee B
AD  - Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
FAU - Ahn, So Min
AU  - Ahn SM
AD  - Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
FAU - Choi, Eun Young
AU  - Choi EY
AD  - Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
AD  - Institute of Vision Research, Yonsei University College of Medicine, Seoul, 
      Korea.
AD  - Institute of Human Barrier Research, Yonsei University College of Medicine, 
      Seoul, Korea.
FAU - Jang, Sungmin
AU  - Jang S
AD  - Retina Center, Saevit Eye Hospital, Goyang, Korea.
FAU - Lee, Kihwang
AU  - Lee K
AD  - Department of Ophthalmology, Ajou University School of Medicine, 164 World 
      Cup-ro, Yeongtong-gu, Suwon, 16499, Korea. kie114@hanmail.net.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20210825
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retinal Telangiectasis/*diagnostic imaging
MH  - Retinal Vessels/diagnostic imaging
MH  - Tomography, Optical Coherence/*methods
PMC - PMC8387352
COIS- The authors declare no competing interests.
EDAT- 2021/08/27 06:00
MHDA- 2021/11/05 06:00
PMCR- 2021/08/25
CRDT- 2021/08/26 06:02
PHST- 2021/04/27 00:00 [received]
PHST- 2021/08/17 00:00 [accepted]
PHST- 2021/08/26 06:02 [entrez]
PHST- 2021/08/27 06:00 [pubmed]
PHST- 2021/11/05 06:00 [medline]
PHST- 2021/08/25 00:00 [pmc-release]
AID - 10.1038/s41598-021-96789-4 [pii]
AID - 96789 [pii]
AID - 10.1038/s41598-021-96789-4 [doi]
PST - epublish
SO  - Sci Rep. 2021 Aug 25;11(1):17198. doi: 10.1038/s41598-021-96789-4.