PMID- 34434127 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240403 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 12 DP - 2021 TI - Dissociation Pattern in Default-Mode Network Homogeneity in Drug-Naive Bipolar Disorder. PG - 699292 LID - 10.3389/fpsyt.2021.699292 [doi] LID - 699292 AB - Default mode network (DMN) plays a key role in the pathophysiology of in bipolar disorder (BD). However, the homogeneity of this network in BD is still poorly understood. This study aimed to investigate abnormalities in the NH of the DMN at rest and the correlation between the NH of DMN and clinical variables in patients with BD. Forty drug-naive patients with BD and thirty-seven healthy control subjects participated in the study. Network homogeneity (NH) and independent component analysis (ICA) methods were used for data analysis. Support vector machines (SVM) method was used to analyze NH in different brain regions. Compared with healthy controls, significantly increased NH in the left superior medial prefrontal cortex (MPFC) and decreased NH in the right posterior cingulate cortex (PCC) and bilateral precuneus were found in patients with BD. NH in the right PCC was positively correlated with the verbal fluency test and verbal function total scores. NH in the left superior MPFC was negatively correlated with triglyceride (TG). NH in the right PCC was positively correlated with TG but negatively correlated with high-density lipoprotein cholesterol (HDL-C). NH in the bilateral precuneus was positively correlated with cholesterol and low-density lipoprotein cholesterol (LDL-C). In addition, NH in the left superior MPFC showed high sensitivity (80.00%), specificity (71.43%), and accuracy (75.61%) in the SVM results. These findings contribute new evidence of the participation of the altered NH of the DMN in the pathophysiology of BD. CI - Copyright (c) 2021 Li, Teng, Qiu, Pan, Wu, Jin, Wang, Chen, Tang, Xiang, De Leon, Huang, Guo, Wang and Wu. FAU - Li, Sujuan AU - Li S AD - National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China. FAU - Teng, Ziwei AU - Teng Z AD - National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China. FAU - Qiu, Yan AU - Qiu Y AD - National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China. FAU - Pan, Pan AU - Pan P AD - National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China. FAU - Wu, Chujun AU - Wu C AD - National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China. FAU - Jin, Kun AU - Jin K AD - National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China. FAU - Wang, Lu AU - Wang L AD - National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China. FAU - Chen, Jindong AU - Chen J AD - National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China. FAU - Tang, Hui AU - Tang H AD - National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China. FAU - Xiang, Hui AU - Xiang H AD - National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China. FAU - De Leon, Sara Arenas AU - De Leon SA AD - Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, United States. FAU - Huang, Jing AU - Huang J AD - National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China. FAU - Guo, Wenbin AU - Guo W AD - National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China. FAU - Wang, Bolun AU - Wang B AD - Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, China. FAU - Wu, Haishan AU - Wu H AD - National Clinical Research Center for Mental Disorders, Department of Psychiatry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China. LA - eng PT - Journal Article DEP - 20210809 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC8380964 OTO - NOTNLM OT - bipolar disorder OT - cognitive dysfunction OT - default mode network OT - dyslipidemia OT - network homogeneity COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2021/08/27 06:00 MHDA- 2021/08/27 06:01 PMCR- 2021/08/09 CRDT- 2021/08/26 06:09 PHST- 2021/04/23 00:00 [received] PHST- 2021/07/13 00:00 [accepted] PHST- 2021/08/26 06:09 [entrez] PHST- 2021/08/27 06:00 [pubmed] PHST- 2021/08/27 06:01 [medline] PHST- 2021/08/09 00:00 [pmc-release] AID - 10.3389/fpsyt.2021.699292 [doi] PST - epublish SO - Front Psychiatry. 2021 Aug 9;12:699292. doi: 10.3389/fpsyt.2021.699292. eCollection 2021.