PMID- 3443452
OWN - NLM
STAT- MEDLINE
DCOM- 19880428
LR  - 20181113
IS  - 0019-2805 (Print)
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Linking)
VI  - 61
IP  - 4
DP  - 1987 Aug
TI  - MRL-lpr/lpr mice show an impairment of IgG aggregate removal which relates to 
      parameters of disease activity.
PG  - 463-7
AB  - MRL-lpr/lpr mice show an age-related impairment in the removal of heat-aggregated 
      IgG (HAGG) from the circulation. The female mice, which have an earlier mortality 
      than their male counterparts, clear HAGG more slowly than the male animals. Delay 
      in clearance of this probe of mononuclear phagocytic system (MPS) function 
      relates directly to high levels of circulating immune complexes (CIC) and to 
      significant renal damage. In addition it relates indirectly to hepatic and 
      splenic uptake of HAGG. MPS saturation plays a significant role in the 
      pathogenesis of the disease seen in MRL-lpr/lpr mice.
FAU - Field, M
AU  - Field M
AD  - Clinical Immunology Division, Kennedy Institute of Rheumatology, Hammersmith, 
      London, U.K.
FAU - Brennan, F M
AU  - Brennan FM
FAU - McCarthy, D
AU  - McCarthy D
FAU - Mumford, P
AU  - Mumford P
FAU - Maini, R N
AU  - Maini RN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 0 (Antigen-Antibody Complex)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Aging/immunology
MH  - Animals
MH  - Antigen-Antibody Complex/*metabolism
MH  - Female
MH  - Half-Life
MH  - Hot Temperature
MH  - Immunoglobulin G/*metabolism
MH  - Lupus Erythematosus, Systemic/*immunology
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Protein Denaturation
MH  - Sex Factors
PMC - PMC1453452
EDAT- 1987/08/01 00:00
MHDA- 1987/08/01 00:01
PMCR- 1988/08/01
CRDT- 1987/08/01 00:00
PHST- 1987/08/01 00:00 [pubmed]
PHST- 1987/08/01 00:01 [medline]
PHST- 1987/08/01 00:00 [entrez]
PHST- 1988/08/01 00:00 [pmc-release]
PST - ppublish
SO  - Immunology. 1987 Aug;61(4):463-7.