PMID- 34434672
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210827
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 13
IP  - 7
DP  - 2021 Jul
TI  - Atypical Subacute Cutaneous Lupus in a Patient on Apixaban Anticoagulation 
      Therapy: A Case Report and Review of the Literature.
PG  - e16571
LID - 10.7759/cureus.16571 [doi]
LID - e16571
AB  - Subacute cutaneous lupus erythematosus (SCLE) is a rare cutaneous lupus 
      erythematosus (CLE) subtype manifesting in middle-aged Caucasians with 
      photo-distributed papulosquamous or annular lesions. Drug-induced SCLE (DI-SCLE) 
      forms present in a similar manner but direct oral anticoagulants are rarely 
      implicated. We report an unusual case of SCLE in a 37-year-old African American 
      patient with a history of unprovoked deep vein thromboses (DVT) who presented 
      with new-onset photoprotected polymorphic lesions two months after the initiation 
      of apixaban anticoagulation therapy. Our case demonstrates the heterogeneous 
      nature of SCLE presentation and highlights the possibility of apixaban as a 
      potential causative agent of DI-SCLE in immunogenetically susceptible 
      individuals. Moreover, we hypothesize on the etiopathogenesis of our patient's 
      atypical presentation.
CI  - Copyright (c) 2021, Rakita et al.
FAU - Rakita, Uros
AU  - Rakita U
AD  - Dermatology, Chicago Medical School, Rosalind Franklin University of Medicine and 
      Science, North Chicago, USA.
FAU - Grushchak, Solomiya
AU  - Grushchak S
AD  - Department of Dermatology, John H. Stroger, Jr. Hospital of Cook County, Chicago, 
      USA.
FAU - Guo, Lily
AU  - Guo L
AD  - Dermatology, Chicago Medical School, Rosalind Franklin University of Medicine and 
      Science, North Chicago, USA.
FAU - Braniecki, Marylee
AU  - Braniecki M
AD  - Department of Dermatology, John H. Stroger, Jr. Hospital of Cook County, Chicago, 
      USA.
FAU - Mehta, Shilpa
AU  - Mehta S
AD  - Department of Dermatology, John H. Stroger, Jr. Hospital of Cook County, Chicago, 
      USA.
LA  - eng
PT  - Case Reports
DEP - 20210722
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC8380169
OTO - NOTNLM
OT  - apixaban
OT  - cutaneous lupus erythematosus
OT  - skin of color
OT  - subacute cutaneous lupus erythematosus
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/08/27 06:00
MHDA- 2021/08/27 06:01
PMCR- 2021/07/22
CRDT- 2021/08/26 06:15
PHST- 2021/07/05 00:00 [accepted]
PHST- 2021/08/26 06:15 [entrez]
PHST- 2021/08/27 06:00 [pubmed]
PHST- 2021/08/27 06:01 [medline]
PHST- 2021/07/22 00:00 [pmc-release]
AID - 10.7759/cureus.16571 [doi]
PST - epublish
SO  - Cureus. 2021 Jul 22;13(7):e16571. doi: 10.7759/cureus.16571. eCollection 2021 
      Jul.