PMID- 34435248
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20220405
IS  - 1432-1246 (Electronic)
IS  - 0340-0131 (Linking)
VI  - 95
IP  - 2
DP  - 2022 Mar
TI  - Induced sputum abnormalities in gas station attendants.
PG  - 341-349
LID - 10.1007/s00420-021-01755-2 [doi]
AB  - PURPOSE: To investigate inflammatory changes in the induced sputum (IS) of gas 
      station attendants (GSAs) at risk of exposure to fuel vapors through inhalation 
      and susceptible to respiratory complaints and impaired lung function. METHODS: 
      Hypertonic saline-IS was collected from 52 GSAs who had never smoked (42 men, 
      age = 35.9 +/- 8.9 years) and had no known comorbidities. A group of 22 non-smokers 
      (11 men, age = 30.5 +/- 5.1 years) selected from the University staff served as 
      control. The GSAs answered a questionnaire and underwent spirometry and chest 
      tomography. A total of 15 inflammatory biomarkers associated with inflammation, 
      including cytokines, chemokines, and mediators of immunological response, were 
      also measured. RESULTS: The most common symptoms of GSAs were coughing (42.3%) 
      and dyspnea (59.6%) based on the New York Heart Association (NYHA; Class II) 
      classification. Significant elevations (p < 0.05) in forced vital capacity and 
      forced expiratory volume within the first second were observed in the GSAs 
      relative to those in the controls (GSA vs. control: 99 +/- 12% vs. 90 +/- 9% and 
      94 +/- 11% vs. 87 +/- 10%, respectively). The GSAs had a lower percentage of IS 
      lymphocytes than that in the control group (4.5 +/- 5.7% vs. 7.7 +/- 9.8%). The GSAs 
      also had significantly lower concentrations of IL-4, IL-5, IL-10, IL-12(P70), 
      IFN-gamma, and MIP-1alpha, but IL-3 levels were higher. No differences were observed in 
      the airway thickness and the amount of emphysema between the GSAs and the 
      controls. CONCLUSION: Despite normal lung function and absence of abnormalities 
      on HRCT, GSAs have a higher frequency of respiratory complaints, with evidence of 
      impairment of lymphocytic activity in the airways.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - da Silva, Tiago Henrique Garcia
AU  - da Silva THG
AD  - Internal Medicine Department. Medical School of Ribeirao Preto, University of Sao 
      Paulo, Avenida Bandeirantes 3900, Ribeirao Preto, SP, 14048-900, Brazil.
FAU - Gastaldi, Ada Clarice
AU  - Gastaldi AC
AUID- ORCID: 0000-0001-9845-3611
AD  - Department of Health Sciences, Medical School of Ribeirao Preto, University of 
      Sao Paulo, Ribeirao Preto, SP, Brazil.
FAU - Santos, Marcel Koenigkam
AU  - Santos MK
AUID- ORCID: 0000-0002-7160-4691
AD  - Department of Medical Imaging, Hematology and Oncology, Medical School of 
      Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
FAU - de Martinis, Bruno Spinosa
AU  - de Martinis BS
AUID- ORCID: 0000-0002-2702-5190
AD  - Department of Chemistry, Faculty of Philosophy, Science and Languages of Ribeirao 
      Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
FAU - Baddini-Martinez, Jose
AU  - Baddini-Martinez J
AUID- ORCID: 0000-0001-8160-5084
AD  - Internal Medicine Department. Medical School of Ribeirao Preto, University of Sao 
      Paulo, Avenida Bandeirantes 3900, Ribeirao Preto, SP, 14048-900, Brazil. 
      baddini@fmrp.usp.br.
LA  - eng
GR  - 2016/10685-9/Fundacao de Amparo a Pesquisa do Estado de Sao Paulo/
PT  - Journal Article
DEP - 20210825
PL  - Germany
TA  - Int Arch Occup Environ Health
JT  - International archives of occupational and environmental health
JID - 7512134
SB  - IM
MH  - Adult
MH  - Forced Expiratory Volume
MH  - Humans
MH  - *Lung
MH  - Male
MH  - Spirometry
MH  - *Sputum
MH  - Vital Capacity
OTO - NOTNLM
OT  - Airways
OT  - Chest tomography
OT  - Gas station attendants
OT  - Induced sputum
OT  - Pulmonary function
OT  - Volatile organic compounds
EDAT- 2021/08/27 06:00
MHDA- 2022/04/05 06:00
CRDT- 2021/08/26 06:22
PHST- 2021/02/05 00:00 [received]
PHST- 2021/07/01 00:00 [accepted]
PHST- 2021/08/27 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2021/08/26 06:22 [entrez]
AID - 10.1007/s00420-021-01755-2 [pii]
AID - 10.1007/s00420-021-01755-2 [doi]
PST - ppublish
SO  - Int Arch Occup Environ Health. 2022 Mar;95(2):341-349. doi: 
      10.1007/s00420-021-01755-2. Epub 2021 Aug 25.